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4GJ2

Tyk2 (JH1) in complex with 2,6-dichloro-N-[2-({[(1R,2R)-2-fluorocyclopropyl]carbonyl}amino)pyridin-4-yl]benzamide

Summary for 4GJ2
Entry DOI10.2210/pdb4gj2/pdb
Related4GI3 4GIH 4GII 4GVJ
DescriptorNon-receptor tyrosine-protein kinase TYK2, 2,6-dichloro-N-[2-({[(1R,2R)-2-fluorocyclopropyl]carbonyl}amino)pyridin-4-yl]benzamide (3 entities in total)
Functional Keywordskinase, atp binding, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (human)
Total number of polymer chains1
Total formula weight35116.92
Authors
Ultsch, M.H. (deposition date: 2012-08-09, release date: 2013-05-29, Last modification date: 2023-09-13)
Primary citationLiang, J.,van Abbema, A.,Balazs, M.,Barrett, K.,Berezhkovsky, L.,Blair, W.,Chang, C.,Delarosa, D.,Devoss, J.,Driscoll, J.,Eigenbrot, C.,Ghilardi, N.,Gibbons, P.,Halladay, J.,Johnson, A.,Kohli, P.B.,Lai, Y.,Liu, Y.,Lyssikatos, J.,Mantik, P.,Menghrajani, K.,Murray, J.,Peng, I.,Sambrone, A.,Shia, S.,Shin, Y.,Smith, J.,Sohn, S.,Tsui, V.,Ultsch, M.,Wu, L.C.,Xiao, Y.,Yang, W.,Young, J.,Zhang, B.,Zhu, B.Y.,Magnuson, S.
Lead Optimization of a 4-Aminopyridine Benzamide Scaffold To Identify Potent, Selective, and Orally Bioavailable TYK2 Inhibitors.
J.Med.Chem., 56:4521-4536, 2013
Cited by
PubMed: 23668484
DOI: 10.1021/jm400266t
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.4 Å)
Structure validation

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