4GVJ

Tyk2 (JH1) in complex with adenosine di-phosphate

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Non-receptor tyrosine-protein kinase TYK2	polymer	302	34749.7	1	UniProt (P29597) Pfam (PF07714)	Homo sapiens (human)
2	B (A)	ADENOSINE-5'-DIPHOSPHATE	non-polymer		427.2	1	Chemie (ADP)
3	C, D (A)	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
4	E (A)	water	water		18.0	89	Chemie (HOH)

Sequence modifications

A: 885 - 1176 (UniProt: P29597)

PDB	External Database	Details
Met 882	-	expression tag
Gly 883	-	expression tag
Ser 884	-	expression tag
Ala 936	Cys 936	engineered mutation
Ala 969	Gln 969	engineered mutation
Ala 971	Glu 971	engineered mutation
Ala 972	Lys 972	engineered mutation
Ala 1142	Cys 1142	engineered mutation
Arg 1177	-	expression tag
His 1178	-	expression tag
His 1179	-	expression tag
His 1180	-	expression tag
His 1181	-	expression tag
His 1182	-	expression tag
His 1183	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	34749.7
Non-Polymers*	Number of molecules	3
	Total formula weight	475.8
All*	Total formula weight	35225.5

*Water molecules are not included.