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PDB: 40 件
3MWI
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BU of 3mwi by Molmil
The complex crystal Structure of Urokianse and 5-nitro-1H-indole-2-amidine
分子名称: 5-nitro-1H-indole-2-carboximidamide, SULFATE ION, Urokinase-type plasminogen activator
著者Jiang, L.G, Yu, H.Y, Yuan, C, Huang, Z.X, Huang, M.D.
登録日2010-05-06
公開日2011-06-01
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.03 Å)
主引用文献The complex crystal Structure of Urokianse and 5-nitro-1H-indole-2-amidine
To be Published
3OX7
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BU of 3ox7 by Molmil
The crystal structure of uPA complex with peptide inhibitor MH027 at pH4.6
分子名称: MH027, SULFATE ION, TETRAETHYLENE GLYCOL, ...
著者Jiang, L.G, Andreasen, P.A, Huang, M.D.
登録日2010-09-21
公開日2011-08-10
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.58 Å)
主引用文献The binding mechanism of a peptidic cyclic serine protease inhibitor
J.Mol.Biol., 412, 2011
3OY6
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BU of 3oy6 by Molmil
The crystal structure of uPA complex with peptide inhibitor MH036 at pH4.6
分子名称: MH036, Urokinase-type plasminogen activator
著者Jiang, L.G, Andreasen, P.A, Huang, M.D.
登録日2010-09-22
公開日2011-08-10
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.31 Å)
主引用文献The binding mechanism of a peptidic cyclic serine protease inhibitor
J.Mol.Biol., 412, 2011
3OY5
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BU of 3oy5 by Molmil
The crystal structure of uPA complex with peptide inhibitor MH027 at pH7.4
分子名称: MH027, SULFATE ION, Urokinase-type plasminogen activator
著者Jiang, L.G, Andreasen, P.A, Huang, M.D.
登録日2010-09-22
公開日2011-08-10
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.31 Å)
主引用文献The binding mechanism of a peptidic cyclic serine protease inhibitor
J.Mol.Biol., 412, 2011
7DZD
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BU of 7dzd by Molmil
Crystal structure of uPA in complex with cleaved camostat
分子名称: 4-carbamimidamidobenzoic acid, TRIETHYLENE GLYCOL, Urokinase-type plasminogen activator
著者Jiang, L.G, Huang, M.D.
登録日2021-01-25
公開日2021-07-14
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structure of uPA in complex with cleaved camostat
To Be Published
5YC6
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BU of 5yc6 by Molmil
The crystal structure of uPA in complex with 4-Bromobenzylamirne at pH4.6
分子名称: 1-(4-BROMOPHENYL)METHANAMINE, SULFATE ION, TRIETHYLENE GLYCOL, ...
著者Jiang, L.G, Zhang, X, Huang, M.D.
登録日2017-09-06
公開日2018-10-03
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.18 Å)
主引用文献Halogen bonding for the design of inhibitors by targeting the S1 pocket of serine proteases
Rsc Adv, 8, 2018
5YC7
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BU of 5yc7 by Molmil
The crystal structure of uPA in complex with 4-Bromobenzylamirne at pH7.4
分子名称: 1-(4-BROMOPHENYL)METHANAMINE, SULFATE ION, Urokinase-type plasminogen activator
著者Jiang, L.G, Zhang, X, Huang, M.D.
登録日2017-09-06
公開日2018-10-03
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Halogen bonding for the design of inhibitors by targeting the S1 pocket of serine proteases
Rsc Adv, 8, 2018
5YUP
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BU of 5yup by Molmil
Crystal Structure of the Fab fragment of FVIIa antibody mAb4F5
分子名称: the heavy chain of the Fab fragment of FVIIa antibody mAb4F5, the light chain of the Fab fragment of FVIIa antibody mAb4F5
著者Jiang, L.G, Persson, E, Huang, M.D.
登録日2017-11-22
公開日2019-06-19
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.81 Å)
主引用文献Crystal structure, epitope, and functional impact of an antibody against a superactive FVIIa provide insights into allosteric mechanism.
Res Pract Thromb Haemost, 3, 2019
5Z1C
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BU of 5z1c by Molmil
The crystal structure of uPA in complex with 4-Iodobenzylamine at pH7.4
分子名称: 1-(4-iodophenyl)methanamine, Urokinase-type plasminogen activator
著者Jiang, L.G, Zhang, X, Luo, Z.P, Huang, M.D.
登録日2017-12-25
公開日2018-12-26
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Halogen bonding for the design of inhibitors by targeting the S1 pocket of serine proteases
Rsc Adv, 49, 2018
7VM4
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BU of 7vm4 by Molmil
Crystal structure of uPA in complex with nafamostat
分子名称: 4-carbamimidamidobenzoic acid, TRIETHYLENE GLYCOL, Urokinase-type plasminogen activator
著者Jiang, L.G, Huang, M.D.
登録日2021-10-07
公開日2022-10-12
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.01 Å)
主引用文献Structural study of the uPA-nafamostat complex reveals a covalent inhibitory mechanism of nafamostat.
Biophys.J., 121, 2022
7VM7
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BU of 7vm7 by Molmil
Crystal structure of inactive uPA in complex with nafamostat
分子名称: (6-carbamimidoylnaphthalen-2-yl) 4-carbamimidamidobenzoate, Urokinase-type plasminogen activator chain B
著者Jiang, L.G, Huang, M.D.
登録日2021-10-07
公開日2022-11-23
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.87 Å)
主引用文献Structural study of the uPA-nafamostat complex reveals a covalent inhibitory mechanism of nafamostat.
Biophys.J., 121, 2022
7VM5
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BU of 7vm5 by Molmil
Crystal structure of uPA in complex with 4-guanidinobenzoic acid
分子名称: 4-carbamimidamidobenzoic acid, TRIETHYLENE GLYCOL, Urokinase-type plasminogen activator
著者Jiang, L.G, Huang, M.D.
登録日2021-10-07
公開日2022-10-12
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.97 Å)
主引用文献Structural study of the uPA-nafamostat complex reveals a covalent inhibitory mechanism of nafamostat.
Biophys.J., 121, 2022
7VM6
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BU of 7vm6 by Molmil
Crystal structure of uPA in complex with 6-amidino-2-naphthol
分子名称: 6-oxidanylnaphthalene-2-carboximidamide, SULFATE ION, TRIETHYLENE GLYCOL, ...
著者Jiang, L.G, Huang, M.D.
登録日2021-10-07
公開日2022-10-12
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.79 Å)
主引用文献Structural study of the uPA-nafamostat complex reveals a covalent inhibitory mechanism of nafamostat.
Biophys.J., 121, 2022
5ZC5
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BU of 5zc5 by Molmil
uPA-NU-09F
分子名称: 3-azanyl-5-(azepan-1-yl)-N-carbamimidoyl-6-(4-fluoranyl-1-benzofuran-2-yl)pyrazine-2-carboxamide, Urokinase-type plasminogen activator chain B
著者Jiang, L.G, Buckley, B.J, Huang, M.D, Kelso, M.J, Ranson, M.
登録日2018-02-15
公開日2018-12-19
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献6-Substituted Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer.
J. Med. Chem., 61, 2018
6XVD
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BU of 6xvd by Molmil
Crystal structure of complex of urokinase and a upain-1 variant(W3F) in pH7.4 condition
分子名称: Urokinase-type plasminogen activator, upain-1-W3F
著者Xue, G.P, Xie, X, Zhou, Y, Yuan, C, Huang, M.D, Jiang, L.G.
登録日2020-01-21
公開日2020-02-19
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Insight to the residue in P2 position prevents the peptide inhibitor from being hydrolyzed by serine proteases.
Biosci.Biotechnol.Biochem., 84, 2020
6JYP
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BU of 6jyp by Molmil
Crystal structure of uPA_H99Y in complex with 3-azanyl-5-(azepan-1-yl)-N-[bis(azanyl)methylidene]-6-chloranyl-pyrazine-2-carboxamide
分子名称: 3-azanyl-5-(azepan-1-yl)-N-[bis(azanyl)methylidene]-6-chloranyl-pyrazine-2-carboxamide, SULFATE ION, Urokinase-type plasminogen activator
著者Buckley, B, Jiang, L.G, Huang, M.D, Kelso, M, Ranson, M.
登録日2019-04-27
公開日2020-05-13
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献uPA-HMA
To Be Published
3G7N
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BU of 3g7n by Molmil
Crystal Structure of a Triacylglycerol Lipase from Penicillium Expansum at 1.3
分子名称: DI(HYDROXYETHYL)ETHER, Lipase, PENTAETHYLENE GLYCOL, ...
著者Bian, C.B, Yuan, C, Chen, L.Q, Edward, J.M, Lin, L, Jiang, L.G, Huang, Z.X, Huang, M.D.
登録日2009-02-10
公開日2010-02-23
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Crystal structure of a triacylglycerol lipase from Penicillium expansum at 1.3 A determined by sulfur SAD
Proteins, 78, 2010
6JYQ
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BU of 6jyq by Molmil
Crystal structure of uPA_H99Y in complex with 3-azanyl-5-(azepan-1-yl)-N-carbamimidoyl-6-(furan-2-yl)pyrazine-2-carboxamide
分子名称: 3-azanyl-5-(azepan-1-yl)-N-carbamimidoyl-6-(furan-2-yl)pyrazine-2-carboxamide, SULFATE ION, Urokinase-type plasminogen activator
著者Buckley, B, Jiang, L.G, Huang, M.D, Kelso, M, Ranson, M.
登録日2019-04-27
公開日2020-05-13
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献H99Y-6F-HMA-pH7
To Be Published
6L05
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BU of 6l05 by Molmil
Crystal structure of uPA_H99Y in complex with 50F
分子名称: 3-azanyl-5-(azepan-1-yl)-6-(1-benzofuran-2-yl)-Ncarbamimidoyl-pyrazine-2-carboxamide, Urokinase-type plasminogen activator
著者Buckley, B, Jiang, L.G, Huang, M.D, Kelso, M, Ranson, M.
登録日2019-09-26
公開日2020-09-30
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.49 Å)
主引用文献Crystal structure of uPA_H99Y in complex with 50F
To Be Published
6L04
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BU of 6l04 by Molmil
Crystal structure of uPA_H99Y in complex with 31F
分子名称: 3-azanyl-5-(azepan-1-yl)-N-carbamimidoyl-6-(2,4-dimethoxypyrimidin-5-yl)pyrazine-2-carboxamide, Urokinase-type plasminogen activator
著者Buckley, B, Jiang, L.G, Huang, M.D, Kelso, M, Ranson, M.
登録日2019-09-26
公開日2020-09-30
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.21 Å)
主引用文献Crystal structure of uPA_H99Y in complex with 31F
To Be Published
7WOK
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BU of 7wok by Molmil
Crystal structure of HSA soaked with cisplatin for one week
分子名称: Albumin, Cisplatin, PHOSPHATE ION
著者Chen, S.L, Yuan, C, Jiang, L.G, Luo, Z.P, Huang, M.D.
登録日2022-01-21
公開日2022-07-20
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Crystallographic analysis of interaction between cisplatin and human serum albumin: Effect of fatty acid.
Int.J.Biol.Macromol., 216, 2022
7WOJ
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BU of 7woj by Molmil
Crystal structure of HSA-Myr complex soaked with cisplatin for one week
分子名称: Albumin, Cisplatin, MYRISTIC ACID
著者Chen, S.L, Yuan, C, Jiang, L.G, Luo, Z.P, Huang, M.D.
登録日2022-01-21
公開日2022-07-20
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.89 Å)
主引用文献Crystallographic analysis of interaction between cisplatin and human serum albumin: Effect of fatty acid.
Int.J.Biol.Macromol., 216, 2022
6AG7
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BU of 6ag7 by Molmil
The crystal structure of uPA in complex with HMA-55F
分子名称: 3,5-diamino-N-carbamimidoyl-6-(1-methyl-1H-pyrazol-4-yl)pyrazine-2-carboxamide, Urokinase-type plasminogen activator
著者Buckley, B, Jiang, L.G, Majed, H, Huang, M.D, Kelso, M, Ranson, M.
登録日2018-08-09
公開日2019-08-14
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献uPA-HMA
To Be Published
6AG3
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BU of 6ag3 by Molmil
Crystal structure of uPA in complex with 3,5-bis(azanyl)-N-carbamimidoyl-6-(2,4-dimethoxypyrimidin-5-yl)pyrazine-2-carboxamide
分子名称: 3,5-bis(azanyl)-N-carbamimidoyl-6-(2,4-dimethoxypyrimidin-5-yl)pyrazine-2-carboxamide, Urokinase-type plasminogen activator
著者Buckley, B, Jiang, L.G, Majed, H, Huang, M.D, Kelso, M, Ranson, M.
登録日2018-08-09
公開日2019-09-18
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.48 Å)
主引用文献uPA-HMA
To Be Published
6AG9
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BU of 6ag9 by Molmil
Crystal structure of uPA in complex with 3,5-bis(azanyl)-6-(1-benzofuran-2-yl)-N-carbamimidoyl-pyrazine-2- carboxamide
分子名称: 3,5-bis(azanyl)-6-(1-benzofuran-2-yl)-N-carbamimidoyl-pyrazine-2-carboxamide, SULFATE ION, Urokinase-type plasminogen activator
著者Buckley, B, Jiang, L.G, Majed, H, Huang, M.D, Kelso, M, Ranson, M.
登録日2018-08-09
公開日2019-09-18
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.63 Å)
主引用文献uPA-HMA
To Be Published

 

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