7B06
| TgoT_RT521 apo | Descriptor: | DNA polymerase | Authors: | Samson, C, Legrand, P, Tekpinar, M, Rozenski, J, Abramov, M, Holliger, P, Pinheiro, V, Herdewijn, P, Delarue, M. | Deposit date: | 2020-11-18 | Release date: | 2020-12-30 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.349 Å) | Cite: | Structural Studies of HNA Substrate Specificity in Mutants of an Archaeal DNA Polymerase Obtained by Directed Evolution. Biomolecules, 10, 2020
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8PNM
| Structure of human KCTD15 BTB domain mutant G88D crystal form 2 | Descriptor: | BTB/POZ domain-containing protein KCTD15 | Authors: | Cruz Walma, D.A, Cros, J, Bradshaw, W, Richardson, W, Chen, Z, Chalk, R, Wilkie, A, Bullock, A.N. | Deposit date: | 2023-06-30 | Release date: | 2024-03-20 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.94 Å) | Cite: | BTB domain mutations perturbing KCTD15 oligomerisation cause a distinctive frontonasal dysplasia syndrome. J Med Genet, 61, 2024
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7B5E
| Structure of calcium-bound mTMEM16A(ac)-I551A chloride channel at 4.1 A resolution | Descriptor: | Anoctamin-1, CALCIUM ION | Authors: | Lam, A.K.M, Rheinberger, J, Paulino, C, Dutzler, R. | Deposit date: | 2020-12-03 | Release date: | 2021-02-10 | Last modified: | 2021-02-17 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Gating the pore of the calcium-activated chloride channel TMEM16A. Nat Commun, 12, 2021
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6V9Z
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7B5Q
| Cryo-EM structure of the human CAK bound to ICEC0942 (PHENIX-OPLS3e) | Descriptor: | (3R,4R)-4-[[[7-[(phenylmethyl)amino]-3-propan-2-yl-pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol, CDK-activating kinase assembly factor MAT1, Cyclin-H, ... | Authors: | Greber, B.J, Remis, J, Ali, S, Nogales, E. | Deposit date: | 2020-12-05 | Release date: | 2021-02-10 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | 2.5 angstrom -resolution structure of human CDK-activating kinase bound to the clinical inhibitor ICEC0942. Biophys.J., 120, 2021
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3RYO
| Crystal Structure of Enhanced Intracellular Survival (Eis) Protein from Mycobacterium tuberculosis with Acetyl CoA | Descriptor: | ACETYL COENZYME *A, Enhanced intracellular survival protein | Authors: | Kim, K.H, An, D.R, Yoon, J.Y, Kim, H.S, Yoon, H.J, Song, J, Im, H.N, Kim, J, Kim, D.J, Lee, S.J, Kim, H.J, Lee, J.Y, Suh, S.W. | Deposit date: | 2011-05-11 | Release date: | 2012-05-23 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Mycobacterium tuberculosis Eis protein initiates suppression of host immune responses by acetylation of DUSP16/MKP-7 Proc.Natl.Acad.Sci.USA, 2012
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3NYJ
| Crystal Structure Analysis of APP E2 domain | Descriptor: | Amyloid beta A4 protein, OSMIUM ION | Authors: | Ha, Y, Hu, J, Lee, S, Liu, X. | Deposit date: | 2010-07-15 | Release date: | 2011-06-01 | Last modified: | 2017-11-08 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | The E2 Domains of APP and APLP1 Share a Conserved Mode of Dimerization. Biochemistry, 50, 2011
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7AJR
| Virtual screening approach leading to the identification of a novel and tractable series of Pseudomonas aeruginosa elastase inhibitors | Descriptor: | 2-[2-(1,3-benzothiazol-2-ylmethylcarbamoyl)-1,3-dihydroinden-2-yl]ethanoic acid, Keratinase KP2, SULFATE ION, ... | Authors: | Leiris, S, Davies, D.T, Sprinsky, N, Castandet, J, Behria, L, Bodnarchuk, M.S, Sutton, J.M, Mullins, T.M.G, Jones, M.W, Forrest, A.K, Pallin, T.D, Karunakar, P, Martha, S.K, Parusharamulu, B, Ramula, R, Kotha, V, Pottabathini, N, Pothukanuri, S, Lemonnier, M, Everett, M. | Deposit date: | 2020-09-29 | Release date: | 2021-02-10 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Virtual Screening Approach to Identifying a Novel and Tractable Series of Pseudomonas aeruginosa Elastase Inhibitors. Acs Med.Chem.Lett., 12, 2021
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7B5C
| Structure of calcium-bound mTMEM16A(ac) chloride channel at 3.7 A resolution | Descriptor: | Anoctamin-1, CALCIUM ION | Authors: | Lam, A.K.M, Rheinberger, J, Paulino, C, Dutzler, R. | Deposit date: | 2020-12-03 | Release date: | 2021-02-10 | Last modified: | 2021-02-17 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Gating the pore of the calcium-activated chloride channel TMEM16A. Nat Commun, 12, 2021
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2JAG
| L1-intermediate of halorhodopsin T203V | Descriptor: | CHLORIDE ION, Halorhodopsin, PALMITIC ACID, ... | Authors: | Gmelin, W, Zeth, K, Efremov, R, Heberle, J, Tittor, J, Oesterhelt, D. | Deposit date: | 2006-11-28 | Release date: | 2006-12-14 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | The crystal structure of the L1 intermediate of halorhodopsin at 1.9 angstroms resolution. Photochem. Photobiol., 83, 2007
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7SXO
| Yeast Lon (PIM1) with endogenous substrate | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Lon protease homolog, ... | Authors: | Yang, J, Song, A.S, Wiseman, R.L, Lander, G.C. | Deposit date: | 2021-11-24 | Release date: | 2022-01-12 | Last modified: | 2022-07-27 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Cryo-EM structure of hexameric yeast Lon protease (PIM1) highlights the importance of conserved structural elements. J.Biol.Chem., 298, 2022
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7SX4
| Human NALCN-FAM155A-UNC79-UNC80 channelosome with CaM bound, conformation 2/2 | Descriptor: | (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE, (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Kschonsak, M, Chua, H.C, Weidling, C, Chakouri, N, Noland, C.L, Schott, K, Chang, T, Tam, C, Patel, N, Arthur, C.P, Leitner, A, Ben-Johny, M, Ciferri, C, Pless, S.A, Payandeh, J. | Deposit date: | 2021-11-22 | Release date: | 2021-12-29 | Last modified: | 2022-03-16 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structural architecture of the human NALCN channelosome. Nature, 603, 2022
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7SVR
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6VGY
| 2.05 A resolution structure of MERS 3CL protease in complex with inhibitor 6b | Descriptor: | N~2~-{[(trans-4-ethylcyclohexyl)oxy]carbonyl}-N-{(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-leucinamide, Orf1a protein | Authors: | Lovell, S, Battaile, K.P, Kashipathy, M.M, Rathnayake, A.D, Zheng, J, Kim, Y, Nguyen, H.N, Chang, K.O, Groutas, W.C. | Deposit date: | 2020-01-09 | Release date: | 2020-08-12 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | 3C-like protease inhibitors block coronavirus replication in vitro and improve survival in MERS-CoV-infected mice. Sci Transl Med, 12, 2020
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7SV7
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6UPR
| Crystal Structure of GTPase Domain of Human Septin 2 / Septin 8 Heterocomplex | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Leonardo, D.A, Pereira, H.M, Brandao-Neto, J, Araujo, A.P.U, Garratt, R.C. | Deposit date: | 2019-10-18 | Release date: | 2020-09-23 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.299 Å) | Cite: | Molecular Recognition at Septin Interfaces: The Switches Hold the Key. J.Mol.Biol., 432, 2020
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6UPT
| Tudor Domain of Tumor suppressor p53BP1 with MFP-2706 | Descriptor: | 2-((2-chlorobenzyl)thio)-4,5-dihydro-1H-imidazole, TP53-binding protein 1, UNKNOWN ATOM OR ION | Authors: | The, J, Dong, A, Headey, S, Gunzburg, M, Doak, B, James, L.I, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Structural Genomics Consortium (SGC) | Deposit date: | 2019-10-18 | Release date: | 2019-11-20 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.96 Å) | Cite: | Tudor Domain of Tumor suppressor p53BP1 with MFP-2706 to be published
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3NP5
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6V1A
| immune receptor complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Fibrinogen beta 74cit69-81, GLYCEROL, ... | Authors: | Lim, J.J, Rossjohn, J. | Deposit date: | 2019-11-20 | Release date: | 2020-11-25 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.29 Å) | Cite: | The shared susceptibility epitope of HLA-DR4 binds citrullinated self-antigens and the TCR. Sci Immunol, 6, 2021
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7SVD
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7SUN
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7T3D
| CryoEM map of anchor 222-1C06 Fab and lateral patch 2B05 Fab binding H1 HA | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 222-1C06 mAb heavy chain, ... | Authors: | Han, J, Ward, A.B. | Deposit date: | 2021-12-07 | Release date: | 2022-01-12 | Last modified: | 2022-03-30 | Method: | ELECTRON MICROSCOPY (3.38 Å) | Cite: | Broadly neutralizing antibodies target a haemagglutinin anchor epitope. Nature, 602, 2022
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4D90
| Crystal Structure of Del-1 EGF domains | Descriptor: | 2-acetamido-2-deoxy-beta-D-galactopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | Authors: | Chen, Q, Schurpf, T, Springer, T, Wang, J. | Deposit date: | 2012-01-11 | Release date: | 2012-05-30 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.601 Å) | Cite: | The RGD finger of Del-1 is a unique structural feature critical for integrin binding. Faseb J., 26, 2012
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2JSA
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7B6B
| The carbohydrate binding module family 48 (CBM48) and carboxy-terminal carbohydrate esterase family 1 (CE1) domains of the multidomain esterase DmCE1B from Dysgonomonas mossii in complex with methyl ferulate | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, Carbohydrate Esterase family 1 protein with an N-terminal carbohydrate binding module family 48, ... | Authors: | Mazurkewich, S, Kmezik, C, Branden, G, Larsbrink, J. | Deposit date: | 2020-12-07 | Release date: | 2021-03-10 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.41 Å) | Cite: | A polysaccharide utilization locus from the gut bacterium Dysgonomonas mossii encodes functionally distinct carbohydrate esterases. J.Biol.Chem., 296, 2021
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