7SVR

The complex of dephosphorylated human cystic fibrosis transmembrane conductance regulator (CFTR) and Lumacaftor (VX-809)

Summary for 7SVR

Entry DOI	10.2210/pdb7svr/pdb
EMDB information	25452
Descriptor	Cystic fibrosis transmembrane conductance regulator, Lumacaftor (3 entities in total)
Functional Keywords	abc transporter, ion channel, folding correction, membrane protein, atp-binding protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	170422.87
Authors	Fiedorczuk, K.,Chen, J. (deposition date: 2021-11-19, release date: 2022-01-12, Last modification date: 2024-02-28)
Primary citation	Fiedorczuk, K.,Chen, J. Mechanism of CFTR correction by type I folding correctors. Cell, 185:158-168.e11, 2022 Cited by PubMed: 34995514 DOI: 10.1016/j.cell.2021.12.009 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.9 Å)

Structure validation