7SVR
The complex of dephosphorylated human cystic fibrosis transmembrane conductance regulator (CFTR) and Lumacaftor (VX-809)
Summary for 7SVR
Entry DOI | 10.2210/pdb7svr/pdb |
EMDB information | 25452 |
Descriptor | Cystic fibrosis transmembrane conductance regulator, Lumacaftor (3 entities in total) |
Functional Keywords | abc transporter, ion channel, folding correction, membrane protein, atp-binding protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 170422.87 |
Authors | Fiedorczuk, K.,Chen, J. (deposition date: 2021-11-19, release date: 2022-01-12, Last modification date: 2024-02-28) |
Primary citation | Fiedorczuk, K.,Chen, J. Mechanism of CFTR correction by type I folding correctors. Cell, 185:158-168.e11, 2022 Cited by PubMed: 34995514DOI: 10.1016/j.cell.2021.12.009 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.9 Å) |
Structure validation
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