7T3D

CryoEM map of anchor 222-1C06 Fab and lateral patch 2B05 Fab binding H1 HA

Summary for 7T3D

• Entry DOI: 10.2210/pdb7t3d/pdb
• EMDB information: 25634 25635 25636 25637 25638 25639 25640 25641 25642 25643 25644 25645 25646 25655
• Descriptor: Hemagglutinin HA1 chain, Hemagglutinin HA2 chain, 2B05 mAb light chain, ... (8 entities in total)
• Functional Keywords: anchor, antibodies, influenza a virus, hemagglutinin, immune system, viral protein-immune system complex, viral protein/immune system
• Biological source: Influenza A virus (A/California/04/2009(H1N1)); More
• Total number of polymer chains: 18
• Total formula weight: 323989.03

Authors

Han, J.,Ward, A.B. (deposition date: 2021-12-07, release date: 2022-01-12, Last modification date: 2022-03-30)

• Primary citation: Guthmiller, J.J.,Han, J.,Utset, H.A.,Li, L.,Lan, L.Y.,Henry, C.,Stamper, C.T.,McMahon, M.,O'Dell, G.,Fernandez-Quintero, M.L.,Freyn, A.W.,Amanat, F.,Stovicek, O.,Gentles, L.,Richey, S.T.,de la Pena, A.T.,Rosado, V.,Dugan, H.L.,Zheng, N.Y.,Tepora, M.E.,Bitar, D.J.,Changrob, S.,Strohmeier, S.,Huang, M.,Garcia-Sastre, A.,Liedl, K.R.,Bloom, J.D.,Nachbagauer, R.,Palese, P.,Krammer, F.,Coughlan, L.,Ward, A.B.,Wilson, P.C.; Broadly neutralizing antibodies target a haemagglutinin anchor epitope.; Nature, 602:314-320, 2022; PubMed: 34942633; DOI: 10.1038/s41586-021-04356-8

Experimental method

ELECTRON MICROSCOPY (3.38 Å)