7SV7

The complex of phosphorylated human cystic fibrosis transmembrane conductance regulator (CFTR) with ATP/Mg and Tezacaftor (VX-661)

Summary for 7SV7

Entry DOI	10.2210/pdb7sv7/pdb
EMDB information	25445
Descriptor	Cystic fibrosis transmembrane conductance regulator, Tezacaftor, MAGNESIUM ION, ... (10 entities in total)
Functional Keywords	abc transporter, ion channel, folding correction, atp-binding protein, membrane protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	173532.75
Authors	Fiedorczuk, K.,Chen, J. (deposition date: 2021-11-18, release date: 2022-01-12, Last modification date: 2022-11-02)
Primary citation	Fiedorczuk, K.,Chen, J. Mechanism of CFTR correction by type I folding correctors. Cell, 185:158-168.e11, 2022 Cited by PubMed: 34995514 DOI: 10.1016/j.cell.2021.12.009 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.8 Å)

Structure validation