7SV7
The complex of phosphorylated human cystic fibrosis transmembrane conductance regulator (CFTR) with ATP/Mg and Tezacaftor (VX-661)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cystic fibrosis transmembrane conductance regulator | polymer | 1480 | 168334.5 | 1 | UniProt (P13569) Pfam (PF00664) Pfam (PF00005) Pfam (PF14396) | Homo sapiens (human) | CFTR,ATP-binding cassette sub-family C member 7,Channel conductance-controlling ATPase,cAMP-dependent chloride channel |
| 2 | B (B) | Cystic fibrosis transmembrane conductance regulator | polymer | 17 | 1464.8 | 1 | Homo sapiens (human) | ||
| 3 | C, D (A) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 4 | E, F (A) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 2 | Chemie (ATP) | |||
| 5 | G, H (A) | nonane | non-polymer | 128.3 | 2 | Chemie (DD9) | |||
| 6 | I, J, K, P (A) | DODECANE | non-polymer | 170.3 | 4 | Chemie (D12) | |||
| 7 | L, M (A) | CHOLESTEROL | non-polymer | 386.7 | 2 | Chemie (CLR) | |||
| 8 | N (A) | TETRADECANE | non-polymer | 198.4 | 1 | Chemie (C14) | |||
| 9 | O (A) | heptadecane | non-polymer | 240.5 | 1 | Chemie (PJ8) | |||
| 10 | Q (A) | Tezacaftor | non-polymer | 520.5 | 1 | Chemie (CV6) |
Sequence modifications
A: 1 - 1480 (UniProt: P13569)
| PDB | External Database | Details |
|---|---|---|
| Gln 1371 | Glu 1371 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 169799.3 | |
| Non-Polymers* | Number of molecules | 15 |
| Total formula weight | 3733.5 | |
| All* | Total formula weight | 173532.8 |
