7SVD
The complex of phosphorylated human cystic fibrosis transmembrane conductance regulator (CFTR) with ATP/Mg and Lumacaftor (VX-809)
Summary for 7SVD
Entry DOI | 10.2210/pdb7svd/pdb |
EMDB information | 25445 25447 |
Descriptor | Cystic fibrosis transmembrane conductance regulator, MAGNESIUM ION, ADENOSINE-5'-TRIPHOSPHATE, ... (10 entities in total) |
Functional Keywords | abc transporter, ion channel, folding correction, membrane protein, atp-binding protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 173032.63 |
Authors | Fiedorczuk, K.,Chen, J. (deposition date: 2021-11-18, release date: 2022-01-12, Last modification date: 2024-02-28) |
Primary citation | Fiedorczuk, K.,Chen, J. Mechanism of CFTR correction by type I folding correctors. Cell, 185:158-168.e11, 2022 Cited by PubMed: 34995514DOI: 10.1016/j.cell.2021.12.009 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.7 Å) |
Structure validation
Download full validation report![Download](/newweb/media/icons/dl.png)
![Download](/newweb/media/icons/dl.png)