7SVD
The complex of phosphorylated human cystic fibrosis transmembrane conductance regulator (CFTR) with ATP/Mg and Lumacaftor (VX-809)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cystic fibrosis transmembrane conductance regulator | polymer | 1480 | 168334.5 | 1 | UniProt (P13569) Pfam (PF00664) Pfam (PF00005) Pfam (PF14396) | Homo sapiens (human) | CFTR,ATP-binding cassette sub-family C member 7,Channel conductance-controlling ATPase,cAMP-dependent chloride channel |
| 2 | B (B) | Cystic fibrosis transmembrane conductance regulator | polymer | 17 | 1464.8 | 1 | Homo sapiens (human) | ||
| 3 | C, D (A) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 4 | E, F (A) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 2 | Chemie (ATP) | |||
| 5 | G (A) | DODECANE | non-polymer | 170.3 | 1 | Chemie (D12) | |||
| 6 | H, I (A) | DECANE | non-polymer | 142.3 | 2 | Chemie (D10) | |||
| 7 | J, K, L (A) | CHOLESTEROL | non-polymer | 386.7 | 3 | Chemie (CLR) | |||
| 8 | M (A) | Lumacaftor | non-polymer | 452.4 | 1 | Chemie (VX8) | |||
| 9 | N (A) | UNKNOWN ATOM OR ION | non-polymer | 103.1 | 1 | Chemie (UNX) | |||
| 10 | O (A) | water | water | 18.0 | 2 | Chemie (HOH) |
Sequence modifications
A: 1 - 1480 (UniProt: P13569)
| PDB | External Database | Details |
|---|---|---|
| Gln 1371 | Glu 1371 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 169799.3 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 3233.4 | |
| All* | Total formula weight | 173032.6 |
