3OUB
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![BU of 3oub by Molmil](/molmil-images/mine/3oub) | MDR769 HIV-1 protease complexed with NC/p1 hepta-peptide | Descriptor: | MDR HIV-1 protease, NC/p1 substrate peptide | Authors: | Liu, Z, Wang, Y, Brunzelle, J, Kovari, I.A, Kovari, L.C. | Deposit date: | 2010-09-14 | Release date: | 2011-03-30 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Nine Crystal Structures Determine the Substrate Envelope of the MDR HIV-1 Protease. Protein J., 30, 2011
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7EOX
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![BU of 7eox by Molmil](/molmil-images/mine/7eox) | Protease structure from Euphorbia resinifera | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, IODIDE ION, Protease, ... | Authors: | Siritapetawee, J, Attarataya, J, Charoenwattanasatien, R. | Deposit date: | 2021-04-24 | Release date: | 2022-01-12 | Last modified: | 2023-01-04 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Sequence analysis and crystal structure of a glycosylated protease from Euphorbia resinifera latex for its proteolytic activity aspect. Biotechnol Appl Biochem, 69, 2022
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6PRF
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![BU of 6prf by Molmil](/molmil-images/mine/6prf) | HIV-1 Protease multiple drug resistant clinical isolate mutant PR20 with GRL-14213A | Descriptor: | (3S,3aR,5R,7aS,8S)-hexahydro-4H-3,5-methanofuro[2,3-b]pyran-8-yl [(2S,3R)-4-[{[2-(cyclopropylamino)-1,3-benzothiazol-6-yl]sulfonyl}(2-methylpropyl)amino]-1-(3,5-difluorophenyl)-3-hydroxybutan-2-yl]carbamate, Protease, YTTRIUM ION | Authors: | Kneller, D.W, Agniswamy, J, Weber, I.T. | Deposit date: | 2019-07-10 | Release date: | 2019-09-18 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.21 Å) | Cite: | Potent antiviral HIV-1 protease inhibitor combats highly drug resistant mutant PR20. Biochem.Biophys.Res.Commun., 519, 2019
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6VI0
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![BU of 6vi0 by Molmil](/molmil-images/mine/6vi0) | Cryo-EM structure of VRC01.23 in complex with HIV-1 Env BG505 DS.SOSIP | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BG505 gp120, ... | Authors: | Gorman, J, Kwong, P.D. | Deposit date: | 2020-01-10 | Release date: | 2021-01-13 | Last modified: | 2021-08-25 | Method: | ELECTRON MICROSCOPY (3.43 Å) | Cite: | A matrix of structure-based designs yields improved VRC01-class antibodies for HIV-1 therapy and prevention. Mabs, 13
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7QVB
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3OW8
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![BU of 3ow8 by Molmil](/molmil-images/mine/3ow8) | Crystal Structure of the WD repeat-containing protein 61 | Descriptor: | UNKNOWN ATOM OR ION, WD repeat-containing protein 61 | Authors: | Tempel, W, Li, Z, Chao, X, Lam, R, Wernimont, A.K, He, H, Seitova, A, Pan, P.W, Li, Y, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Min, J, Structural Genomics Consortium (SGC) | Deposit date: | 2010-09-17 | Release date: | 2010-09-29 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure and function of WD40 domain proteins. Protein Cell, 2, 2011
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8AFN
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![BU of 8afn by Molmil](/molmil-images/mine/8afn) | Small molecule stabilizer (compound 1) for ERalpha and 14-3-3 | Descriptor: | 1-[2-(4-chloranylphenoxy)-2-methyl-propanoyl]-~{N}-[2-[2-(dimethylamino)ethyldisulfanyl]ethyl]piperidine-4-carboxamide, 14-3-3 protein sigma, Estrogen receptor, ... | Authors: | Kenanova, D.N, Visser, E.J, Virta, J, Sijbesma, E, Centorrino, F, Zhong, M, Vickery, H, Neitz, J, Brunsveld, L, Ottmann, C, Arkin, M.R. | Deposit date: | 2022-07-18 | Release date: | 2023-04-26 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.36 Å) | Cite: | A Systematic Approach to the Discovery of Protein-Protein Interaction Stabilizers. Acs Cent.Sci., 9, 2023
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4NPJ
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![BU of 4npj by Molmil](/molmil-images/mine/4npj) | Extended-Synaptotagmin 2, C2A- and C2B-domains | Descriptor: | ACETATE ION, CHLORIDE ION, Extended synaptotagmin-2, ... | Authors: | Tomchick, D.R, Rizo, J, Xu, J. | Deposit date: | 2013-11-21 | Release date: | 2014-01-29 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.101 Å) | Cite: | Structure and ca(2+)-binding properties of the tandem c2 domains of e-syt2. Structure, 22, 2014
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5YH0
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![BU of 5yh0 by Molmil](/molmil-images/mine/5yh0) | The structure of DrFam20C1 | Descriptor: | DrFam20C1 | Authors: | Zhang, H, Xiao, J. | Deposit date: | 2017-09-27 | Release date: | 2018-04-11 | Method: | X-RAY DIFFRACTION (3.45 Å) | Cite: | Structure and evolution of the Fam20 kinases Nat Commun, 9, 2018
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6PI6
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![BU of 6pi6 by Molmil](/molmil-images/mine/6pi6) | The evolving story of AtzT, a periplasmic binding protein | Descriptor: | 4-(ethylamino)-6-[(propan-2-yl)amino]-1,3,5-triazin-2-ol, Atrazine periplasmic binding protein, DIMETHYL SULFOXIDE | Authors: | Peat, T.S, Newman, J, Scott, C, Esquirol, L, Dennis, M, Nebl, T. | Deposit date: | 2019-06-26 | Release date: | 2019-11-13 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | The evolving story of AtzT, a periplasmic binding protein. Acta Crystallogr D Struct Biol, 75, 2019
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7QUU
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![BU of 7quu by Molmil](/molmil-images/mine/7quu) | Red1-Iss10 complex | Descriptor: | NURS complex subunit red1, Uncharacterized protein C7D4.14c | Authors: | Mackereth, C.D, Kadlec, J, Laroussi, H. | Deposit date: | 2022-01-18 | Release date: | 2022-09-07 | Last modified: | 2024-06-19 | Method: | SOLUTION NMR | Cite: | Structural analysis of Red1 as a conserved scaffold of the RNA-targeting MTREC/PAXT complex. Nat Commun, 13, 2022
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4NCW
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![BU of 4ncw by Molmil](/molmil-images/mine/4ncw) | foldon domain wild type C-conjugate | Descriptor: | Fibritin, N,N',N''-triethylbenzene-1,3,5-tricarboxamide | Authors: | Graewert, M.A, Berthelmann, A, Lach, J, Groll, M, Eichler, J. | Deposit date: | 2013-10-25 | Release date: | 2014-03-12 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Versatile C(3)-symmetric scaffolds and their use for covalent stabilization of the foldon trimer. Org.Biomol.Chem., 12, 2014
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7XNE
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![BU of 7xne by Molmil](/molmil-images/mine/7xne) | Crystal structure of CBP bromodomain liganded with Y08284 | Descriptor: | CREB-binding protein, GLYCEROL, N-[3-(1-cyclopropylpyrazol-4-yl)-2-fluoranyl-5-[(1S)-1-oxidanylethyl]phenyl]-3-ethanoyl-7-methoxy-indolizine-1-carboxamide | Authors: | Xiang, Q, Wang, C, Wu, T, Zhang, C, Hu, Q, Luo, G, Hu, J, Zhuang, X, Zou, L, Shen, H, Wu, X, Zhang, Y, Kong, X, Xu, Y. | Deposit date: | 2022-04-28 | Release date: | 2022-07-06 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.17 Å) | Cite: | Design, Synthesis, and Biological Evaluation of 1-(Indolizin-3-yl)ethan-1-ones as CBP Bromodomain Inhibitors for the Treatment of Prostate Cancer. J.Med.Chem., 65, 2022
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8APX
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6PKS
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![BU of 6pks by Molmil](/molmil-images/mine/6pks) | MicroED structure of proteinase K from low-dose merged lamellae that were not pre-coated with platinum 2.16A resolution (LD) | Descriptor: | Proteinase K | Authors: | Martynowycz, M.W, Zhao, W, Hattne, J, Jensen, G.J, Gonen, T. | Deposit date: | 2019-06-29 | Release date: | 2019-09-04 | Last modified: | 2019-12-18 | Method: | ELECTRON CRYSTALLOGRAPHY (2.16 Å) | Cite: | Qualitative Analyses of Polishing and Precoating FIB Milled Crystals for MicroED. Structure, 27, 2019
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8AK1
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![BU of 8ak1 by Molmil](/molmil-images/mine/8ak1) | Crystal structure of a CagI:K2 complex | Descriptor: | Cag pathogenicity island protein (Cag19), Designed Ankyrin Repeat Protein K2 | Authors: | Blanc, M, Guerin, J, Terradot, L. | Deposit date: | 2022-07-29 | Release date: | 2023-05-17 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.84 Å) | Cite: | Designed Ankyrin Repeat Proteins provide insights into the structure and function of CagI and are potent inhibitors of CagA translocation by the Helicobacter pylori type IV secretion system. Plos Pathog., 19, 2023
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5Y70
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![BU of 5y70 by Molmil](/molmil-images/mine/5y70) | NMR structure of KMP11 in DPC micelle | Descriptor: | Kinetoplastid membrane protein 11 | Authors: | Lu, Y, Lim, L.Z, Song, J. | Deposit date: | 2017-08-16 | Release date: | 2018-02-07 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Kinetoplastid membrane protein-11 adopts a four-helix bundle fold in DPC micelle. FEBS Lett., 591, 2017
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8SK5
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![BU of 8sk5 by Molmil](/molmil-images/mine/8sk5) | Crystal structure of the SARS-CoV-2 neutralizing VHH 7A9 bound to the spike receptor binding domain | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S1, anti-SARS-CoV-2 receptor binding domain VHH | Authors: | Noland, C.L, Pande, K, Zhang, L, Zhou, H, Galli, J, Eddins, M, Gomez-Llorente, Y. | Deposit date: | 2023-04-18 | Release date: | 2023-08-16 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.011 Å) | Cite: | Discovery and multimerization of cross-reactive single-domain antibodies against SARS-like viruses to enhance potency and address emerging SARS-CoV-2 variants. Sci Rep, 13, 2023
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6VJX
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8AIW
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![BU of 8aiw by Molmil](/molmil-images/mine/8aiw) | Structure of the K5/CagI complex | Descriptor: | Cag pathogenicity island protein (Cag19), Designed Ankyrin Repeat Protein K5 | Authors: | Blanc, M, Guerin, J, Terradot, L. | Deposit date: | 2022-07-27 | Release date: | 2023-05-17 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Designed Ankyrin Repeat Proteins provide insights into the structure and function of CagI and are potent inhibitors of CagA translocation by the Helicobacter pylori type IV secretion system. Plos Pathog., 19, 2023
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7X2E
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5YAX
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![BU of 5yax by Molmil](/molmil-images/mine/5yax) | Crystal structure of a human neutralizing antibody bound to a HBV preS1 peptide | Descriptor: | Large envelope protein, SODIUM ION, scFv1 antibody | Authors: | Liu, X, Zheng, S, Ye, K, Sui, J. | Deposit date: | 2017-09-02 | Release date: | 2017-10-11 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | A potent human neutralizing antibody Fc-dependently reduces established HBV infections Elife, 6, 2017
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6VRW
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![BU of 6vrw by Molmil](/molmil-images/mine/6vrw) | Cryo-EM structure of stabilized HIV-1 Env trimer CAP256.wk34.c80 SOSIP.RnS2 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp120, ... | Authors: | Gorman, J, Kwong, P.D. | Deposit date: | 2020-02-10 | Release date: | 2020-03-11 | Last modified: | 2021-10-06 | Method: | ELECTRON MICROSCOPY (3.71 Å) | Cite: | Structure of Super-Potent Antibody CAP256-VRC26.25 in Complex with HIV-1 Envelope Reveals a Combined Mode of Trimer-Apex Recognition. Cell Rep, 31, 2020
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5YS1
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![BU of 5ys1 by Molmil](/molmil-images/mine/5ys1) | Crystal structure of Multicopper Oxidase CueO G304K mutant | Descriptor: | Blue copper oxidase CueO, COPPER (II) ION | Authors: | Wang, H.Q, Liu, X.Q, Zhao, J.T, Yue, Q.X, Yan, Y.H, Dong, Y.H, Fan, Y.L, Tian, J, Wu, N.F, Gong, Y. | Deposit date: | 2017-11-12 | Release date: | 2018-10-17 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.49 Å) | Cite: | Crystal structures of multicopper oxidase CueO G304K mutant: structural basis of the increased laccase activity Sci Rep, 8, 2018
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2W4U
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![BU of 2w4u by Molmil](/molmil-images/mine/2w4u) | Isometrically contracting insect asynchronous flight muscle quick frozen after a length step | Descriptor: | ACTIN, ALPHA SKELETAL MUSCLE, TROPOMYOSIN ALPHA-1 CHAIN, ... | Authors: | Wu, S, Liu, J, Reedy, M.C, Tregear, R.T, Winkler, H, Franzini-Armstrong, C, Sasaki, H, Lucaveche, C, Goldman, Y.E, Reedy, M.K, Taylor, K.A. | Deposit date: | 2008-12-02 | Release date: | 2010-08-25 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (35 Å) | Cite: | Structural Changes in Isometrically Contracting Insect Flight Muscle Trapped Following a Mechanical Perturbation. Plos One, 7, 2012
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