8SK5

Crystal structure of the SARS-CoV-2 neutralizing VHH 7A9 bound to the spike receptor binding domain

Summary for 8SK5

• Entry DOI: 10.2210/pdb8sk5/pdb
• Descriptor: Spike protein S1, anti-SARS-CoV-2 receptor binding domain VHH, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• Functional Keywords: vhh, complex, antiviral protein
• Biological source: Severe acute respiratory syndrome coronavirus 2; More
• Total number of polymer chains: 2
• Total formula weight: 44890.66

Authors

Noland, C.L.,Pande, K.,Zhang, L.,Zhou, H.,Galli, J.,Eddins, M.,Gomez-Llorente, Y. (deposition date: 2023-04-18, release date: 2023-08-16, Last modification date: 2023-09-06)

• Primary citation: Hollingsworth, S.A.,Noland, C.L.,Vroom, K.,Saha, A.,Sam, M.,Gao, Q.,Zhou, H.,Grandy, D.U.,Singh, S.,Wen, Z.,Warren, C.,Ma, X.S.,Malashock, D.,Galli, J.,Go, G.,Eddins, M.,Mayhood, T.,Sathiyamoorthy, K.,Fridman, A.,Raoufi, F.,Gomez-Llorente, Y.,Patridge, A.,Tang, Y.,Chen, S.J.,Bailly, M.,Ji, C.,Kingsley, L.J.,Cheng, A.C.,Geierstanger, B.H.,Gorman, D.M.,Zhang, L.,Pande, K.; Discovery and multimerization of cross-reactive single-domain antibodies against SARS-like viruses to enhance potency and address emerging SARS-CoV-2 variants.; Sci Rep, 13:13668-13668, 2023; PubMed: 37608223; DOI: 10.1038/s41598-023-40919-7

Experimental method

X-RAY DIFFRACTION (2.011 Å)