8AK1

Crystal structure of a CagI:K2 complex

Summary for 8AK1

• Entry DOI: 10.2210/pdb8ak1/pdb
• Related: 8AIW
• Descriptor: Designed Ankyrin Repeat Protein K2, Cag pathogenicity island protein (Cag19) (3 entities in total)
• Functional Keywords: helicobacter pylori type iv secretion system, toxin
• Biological source: synthetic construct; More
• Total number of polymer chains: 2
• Total formula weight: 57851.07

Authors

Blanc, M.,Guerin, J.,Terradot, L. (deposition date: 2022-07-29, release date: 2023-05-17, Last modification date: 2024-02-07)

• Primary citation: Blanc, M.,Lettl, C.,Guerin, J.,Vieille, A.,Furler, S.,Briand-Schumacher, S.,Dreier, B.,Berge, C.,Pluckthun, A.,Vadon-Le Goff, S.,Fronzes, R.,Rousselle, P.,Fischer, W.,Terradot, L.; Designed Ankyrin Repeat Proteins provide insights into the structure and function of CagI and are potent inhibitors of CagA translocation by the Helicobacter pylori type IV secretion system.; Plos Pathog., 19:e1011368-e1011368, 2023; PubMed: 37155700; DOI: 10.1371/journal.ppat.1011368

Experimental method

X-RAY DIFFRACTION (1.84 Å)