6PRF

HIV-1 Protease multiple drug resistant clinical isolate mutant PR20 with GRL-14213A

Summary for 6PRF

Entry DOI	10.2210/pdb6prf/pdb
Related	3UCB 3UF3 4YHQ 6BZ2
Descriptor	Protease, YTTRIUM ION, (3S,3aR,5R,7aS,8S)-hexahydro-4H-3,5-methanofuro[2,3-b]pyran-8-yl [(2S,3R)-4-[{[2-(cyclopropylamino)-1,3-benzothiazol-6-yl]sulfonyl}(2-methylpropyl)amino]-1-(3,5-difluorophenyl)-3-hydroxybutan-2-yl]carbamate, ... (4 entities in total)
Functional Keywords	protease, inhibitor, multiple mutant, viral protein complex, hydrolase, hydrolase-hydrolase inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Human immunodeficiency virus type 1 group M subtype (HIV-1)
Total number of polymer chains	2
Total formula weight	23040.06
Authors	Kneller, D.W.,Agniswamy, J.,Weber, I.T. (deposition date: 2019-07-10, release date: 2019-09-18, Last modification date: 2023-10-11)
Primary citation	Kneller, D.W.,Agniswamy, J.,Ghosh, A.K.,Weber, I.T. Potent antiviral HIV-1 protease inhibitor combats highly drug resistant mutant PR20. Biochem.Biophys.Res.Commun., 519:61-66, 2019 Cited by PubMed: 31474336 DOI: 10.1016/j.bbrc.2019.08.126 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.21 Å)

Structure validation