6UYG
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![BU of 6uyg by Molmil](/molmil-images/mine/6uyg) | Structure of Hepatitis C Virus Envelope Glycoprotein E2c3 core from genotype 6a bound to broadly neutralizing antibody AR3A and non neutralizing antibody E1 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein E2, ... | Authors: | Tzarum, N, Wilson, I.A, Zhu, J. | Deposit date: | 2019-11-13 | Release date: | 2020-04-22 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.375 Å) | Cite: | Proof of concept for rational design of hepatitis C virus E2 core nanoparticle vaccines. Sci Adv, 6, 2020
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8RV2
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![BU of 8rv2 by Molmil](/molmil-images/mine/8rv2) | Structure of the formin INF2 bound to the barbed end of F-actin. | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Actin, ... | Authors: | Oosterheert, W, Boiero Sanders, M, Funk, J, Prumbaum, D, Raunser, S, Bieling, P. | Deposit date: | 2024-01-31 | Release date: | 2024-04-10 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (3.41 Å) | Cite: | Molecular mechanism of actin filament elongation by formins. Science, 384, 2024
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8SHR
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![BU of 8shr by Molmil](/molmil-images/mine/8shr) | Crystal Structure of PRMT3 with Compound YD1-214 | Descriptor: | 5'-S-[2-(phenylcarbamamido)ethyl]-5'-thioadenosine, Protein arginine N-methyltransferase 3 | Authors: | Song, X, Dong, A, Deng, Y, Huang, R, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | Deposit date: | 2023-04-14 | Release date: | 2024-04-17 | Method: | X-RAY DIFFRACTION (1.92 Å) | Cite: | Crystal Structure of PRMT3 with Compound YD1-214 To be published
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6V01
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![BU of 6v01 by Molmil](/molmil-images/mine/6v01) | structure of human KCNQ1-KCNE3-CaM complex with PIP2 | Descriptor: | CALCIUM ION, Calmodulin-1, Potassium voltage-gated channel subfamily E member 3, ... | Authors: | Mackinnon, R, Sun, J. | Deposit date: | 2019-11-18 | Release date: | 2019-12-04 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Structural Basis of Human KCNQ1 Modulation and Gating. Cell, 180, 2020
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6V0L
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![BU of 6v0l by Molmil](/molmil-images/mine/6v0l) | PDGFR-b Promoter Forms a G-Vacancy Quadruplex that Can be Complemented by dGMP: Molecular Structure and Recognition of Guanine Derivatives and Metabolites | Descriptor: | 2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE, DNA (5'-D(*(3D1)P*AP*GP*GP*GP*AP*GP*GP*GP*CP*GP*GP*CP*GP*GP*GP*AP*CP*A)-3') | Authors: | Wang, K.B, Dickerhoff, J, Wu, G, Yang, D. | Deposit date: | 2019-11-18 | Release date: | 2020-03-11 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | PDGFR-beta Promoter Forms a Vacancy G-Quadruplex that Can Be Filled in by dGMP: Solution Structure and Molecular Recognition of Guanine Metabolites and Drugs. J.Am.Chem.Soc., 142, 2020
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8SI0
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![BU of 8si0 by Molmil](/molmil-images/mine/8si0) | |
333D
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![BU of 333d by Molmil](/molmil-images/mine/333d) | THE CRYSTAL STRUCTURE OF AN RNA OLIGOMER INCORPORATING TANDEM ADENOSINE-INOSINE MISMATCHES | Descriptor: | CALCIUM ION, RNA (5'-R(*CP*GP*CP*AP*IP*GP*CP*G)-3') | Authors: | Carter, R.J, Baeyens, K.J, SantaLucia Jr, J, Turner, D.H, Holbrook, S.R. | Deposit date: | 1997-05-20 | Release date: | 1997-10-16 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.52 Å) | Cite: | The crystal structure of an RNA oligomer incorporating tandem adenosine-inosine mismatches. Nucleic Acids Res., 25, 1997
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6V1V
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![BU of 6v1v by Molmil](/molmil-images/mine/6v1v) | VIP3B (VIP3B_2160) adapted for crystallization | Descriptor: | Vegetative insecticidal protein | Authors: | Evdokimov, A.G, Zheng, M, Moshiri, F, Haas, J, Lowder, C. | Deposit date: | 2019-11-21 | Release date: | 2019-12-18 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (3.189 Å) | Cite: | Crystal structure of a Vip3B family insecticidal protein reveals a new fold and a unique tetrameric assembly. Protein Sci., 29, 2020
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7PS8
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![BU of 7ps8 by Molmil](/molmil-images/mine/7ps8) | NMR Structure of the U3 RNA G-quadruplex | Descriptor: | POTASSIUM ION, RNA (5'-R(*CP*AP*GP*GP*GP*AP*GP*GP*UP*GP*UP*GP*GP*CP*CP*UP*GP*GP*GP*CP*GP*GP*G)-3') | Authors: | Marquevielle, J, Amrane, S. | Deposit date: | 2021-09-22 | Release date: | 2023-04-05 | Last modified: | 2024-06-19 | Method: | SOLUTION NMR | Cite: | NMR Structure of the U3 RNA G-quadruplex To Be Published
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8AIY
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![BU of 8aiy by Molmil](/molmil-images/mine/8aiy) | STRUCTURE OF THE LECB LECTIN FROM PSEUDOMONAS AERUGINOSA STRAIN PAO1 IN COMPLEX WITH N-(beta-L-Fucopyranosyl)-biphenyl-3-carboxamide (4i) | Descriptor: | CALCIUM ION, Fucose-binding lectin PA-IIL, N-(beta-L-Fucopyranosyl)-biphenyl-3-carboxamide, ... | Authors: | Meiers, J, Mala, P, Varrot, A, Siebs, E, Imberty, A, Titz, A. | Deposit date: | 2022-07-27 | Release date: | 2022-11-02 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Discovery of N -beta-l-Fucosyl Amides as High-Affinity Ligands for the Pseudomonas aeruginosa Lectin LecB. J.Med.Chem., 65, 2022
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6V2R
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![BU of 6v2r by Molmil](/molmil-images/mine/6v2r) | Crystal Structure of chromodomain of CBX7 mutant V13A in complex with inhibitor UNC3866 | Descriptor: | Chromobox protein homolog 7, UNC3866, UNKNOWN ATOM OR ION | Authors: | Liu, Y, Tempel, W, Walker, J.R, Stuckey, J.I, Dickson, B.M, James, L.I, Frye, S.V, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | Deposit date: | 2019-11-25 | Release date: | 2019-12-25 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structural Basis for the Binding Selectivity of Human CDY Chromodomains. Cell Chem Biol, 27, 2020
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7PVU
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![BU of 7pvu by Molmil](/molmil-images/mine/7pvu) | Crystal structure of p38alpha C162S in complex with CAS2094511-69-8, P 1 21 1 | Descriptor: | Mitogen-activated protein kinase 14, N-(2-cyclobutyl-1H-1,3-benzodiazol-5-yl)-2-fluorobenzene-1-sulfonamide | Authors: | Baginski, B, Pous, J, Gonzalez, L, Macias, M.J, Nebreda, A.R. | Deposit date: | 2021-10-05 | Release date: | 2023-05-17 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.154 Å) | Cite: | Characterization of p38 alpha autophosphorylation inhibitors that target the non-canonical activation pathway. Nat Commun, 14, 2023
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6V2Q
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![BU of 6v2q by Molmil](/molmil-images/mine/6v2q) | HLA-B*57:03 presenting the peptide LSSPVTKSF | Descriptor: | ACETATE ION, Beta-2-microglobulin, HLA-B alpha chain (B*5703GB), ... | Authors: | Maclachlan, B, Rossjohn, J, Vivian, J.P. | Deposit date: | 2019-11-25 | Release date: | 2020-05-20 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | The molecular basis of how buried human leukocyte antigen polymorphism modulates natural killer cell function. Proc.Natl.Acad.Sci.USA, 117, 2020
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5YJH
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![BU of 5yjh by Molmil](/molmil-images/mine/5yjh) | Structural insights into periostin functions | Descriptor: | CALCIUM ION, CHLORIDE ION, MAGNESIUM ION, ... | Authors: | Liu, H, Liu, J, Xu, F. | Deposit date: | 2017-10-10 | Release date: | 2018-05-23 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.957 Å) | Cite: | Structural characterizations of human periostin dimerization and cysteinylation. FEBS Lett., 592, 2018
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2LW8
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![BU of 2lw8 by Molmil](/molmil-images/mine/2lw8) | |
8SHB
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![BU of 8shb by Molmil](/molmil-images/mine/8shb) | Crystal Structure of PRMT3 with Compound YD1-208 | Descriptor: | 5'-S-[3-(N'-phenylcarbamimidamido)propyl]-5'-thioadenosine, Protein arginine N-methyltransferase 3 | Authors: | Song, X, Dong, A, Deng, Y, Huang, R, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | Deposit date: | 2023-04-13 | Release date: | 2024-04-24 | Method: | X-RAY DIFFRACTION (2.09 Å) | Cite: | Crystal Structure of PRMT3 with Compound YD1-208 To be published
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8SHU
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![BU of 8shu by Molmil](/molmil-images/mine/8shu) | Structure of mouse cGAS | Descriptor: | Cyclic GMP-AMP synthase, ZINC ION | Authors: | Wu, S, Sohn, J. | Deposit date: | 2023-04-14 | Release date: | 2024-04-24 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (1.71 Å) | Cite: | The structural basis for 2'-5'/3'-5'-cGAMP synthesis by cGAS. Nat Commun, 15, 2024
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7F4Y
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![BU of 7f4y by Molmil](/molmil-images/mine/7f4y) | Crystal structure of replisomal dimer of DNA polymerase from bacteriophage RB69 with DNA duplexes | Descriptor: | 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*GP*AP*GP*CP*GP*GP*AP*CP*TP*GP*CP*TP*TP*AP*C)-3'), ... | Authors: | Youn, H.-S, Park, J, An, J.Y, Lee, Y, Eom, S.H, Wang, J. | Deposit date: | 2021-06-21 | Release date: | 2021-07-14 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structure of New Binary and Ternary DNA Polymerase Complexes From Bacteriophage RB69. Front Mol Biosci, 8, 2021
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8SIH
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![BU of 8sih by Molmil](/molmil-images/mine/8sih) | Crystal Structure of PRMT4 with Compound YD1-289 | Descriptor: | 5'-{[2-(benzylcarbamamido)ethyl][3-(N'-cyclopentylcarbamimidamido)propyl]amino}-5'-deoxyadenosine, CALCIUM ION, Histone-arginine methyltransferase CARM1 | Authors: | Song, X, Dong, A, Deng, Y, Huang, R, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | Deposit date: | 2023-04-16 | Release date: | 2024-04-24 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Crystal Structure of PRMT4 with Compound YD1-289 To be published
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6PCK
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![BU of 6pck by Molmil](/molmil-images/mine/6pck) | Crystal structure of human diphosphoinositol polyphosphate phosphohydrolase 1 in complex with 1-IP7 | Descriptor: | (1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentakis(phosphonooxy)cyclohexyl trihydrogen diphosphate, CHLORIDE ION, Diphosphoinositol polyphosphate phosphohydrolase 1, ... | Authors: | Dollins, D.E, Neubauer, J, Dong, J, York, J.D. | Deposit date: | 2019-06-17 | Release date: | 2020-04-29 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Vip1 is a kinase and pyrophosphatase switch that regulates inositol diphosphate signaling. Proc.Natl.Acad.Sci.USA, 117, 2020
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6P46
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![BU of 6p46 by Molmil](/molmil-images/mine/6p46) | Cryo-EM structure of TMEM16F in digitonin with calcium bound | Descriptor: | Anoctamin-6, CALCIUM ION | Authors: | Feng, S, Dang, S, Han, T.W, Ye, W, Jin, P, Cheng, T, Li, J, Jan, Y.N, Jan, L.Y, Cheng, Y. | Deposit date: | 2019-05-26 | Release date: | 2019-07-24 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Cryo-EM Studies of TMEM16F Calcium-Activated Ion Channel Suggest Features Important for Lipid Scrambling. Cell Rep, 28, 2019
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6P4N
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![BU of 6p4n by Molmil](/molmil-images/mine/6p4n) | Salmonella typhi PltB Homopentamer with Neu5Ac-alpha-2-6-Gal-beta-1-4-GlcNAc Glycans | Descriptor: | N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Putative pertussis-like toxin subunit | Authors: | Nguyen, T, Milano, S.K, Hillpot, E.C, Yang, Y.A, Song, J. | Deposit date: | 2019-05-28 | Release date: | 2020-03-25 | Last modified: | 2020-08-05 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Salmonella Typhoid Toxin PltB Subunit and Its Non-typhoidal Salmonella Ortholog Confer Differential Host Adaptation and Virulence. Cell Host Microbe, 27, 2020
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6P4S
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![BU of 6p4s by Molmil](/molmil-images/mine/6p4s) | Salmonella typhi PltB Homopentamer T65I Mutant | Descriptor: | Putative pertussis-like toxin subunit | Authors: | Nguyen, T, Milano, S.K, Hillpot, E.C, Yang, Y.A, Song, J. | Deposit date: | 2019-05-28 | Release date: | 2020-03-25 | Last modified: | 2020-08-05 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Salmonella Typhoid Toxin PltB Subunit and Its Non-typhoidal Salmonella Ortholog Confer Differential Host Adaptation and Virulence. Cell Host Microbe, 27, 2020
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6V4Q
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![BU of 6v4q by Molmil](/molmil-images/mine/6v4q) | Crystal structure of a MR78-like antibody naive-1 Fab | Descriptor: | GLYCEROL, ISOPROPYL ALCOHOL, Naive-1 Fab heavy chain, ... | Authors: | Bozhanova, N.G, Crowe, J.E, Meiler, J. | Deposit date: | 2019-11-28 | Release date: | 2020-11-25 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.39 Å) | Cite: | Discovery of Marburg virus neutralizing antibodies from virus-naive human antibody repertoires using large-scale structural predictions. Proc.Natl.Acad.Sci.USA, 117, 2020
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8SHK
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![BU of 8shk by Molmil](/molmil-images/mine/8shk) | |