8SI0

Structure of binary complex of human cGAS and bound cGAMP

Summary for 8SI0

• Entry DOI: 10.2210/pdb8si0/pdb
• Descriptor: Cyclic GMP-AMP synthase, cGAMP, ZINC ION, ... (4 entities in total)
• Functional Keywords: immune system, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 43714.29

Authors

Wu, S.,Sohn, J. (deposition date: 2023-04-14, release date: 2024-04-24, Last modification date: 2024-05-29)

• Primary citation: Wu, S.,Gabelli, S.B.,Sohn, J.; The structural basis for 2'-5'/3'-5'-cGAMP synthesis by cGAS.; Nat Commun, 15:4012-4012, 2024; PubMed: 38740774; DOI: 10.1038/s41467-024-48365-3

Experimental method

X-RAY DIFFRACTION (2.7 Å)