4URS
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![BU of 4urs by Molmil](/molmil-images/mine/4urs) | Crystal Structure of GGDEF domain from T.maritima | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), DIGUANYLATE CYCLASE, ... | Authors: | Deepthi, A, Liew, C.W, Liang, Z.X, Swaminathan, K, Lescar, J. | Deposit date: | 2014-07-02 | Release date: | 2014-10-08 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.27 Å) | Cite: | Structure of a Diguanylate Cyclase from Thermotoga Maritima: Insights Into Activation, Feedback Inhibition and Thermostability Plos One, 9, 2014
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3KKZ
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![BU of 3kkz by Molmil](/molmil-images/mine/3kkz) | Crystal structure of the Q5LES9_BACFN protein from Bacteroides fragilis. Northeast Structural Genomics Consortium Target BfR250. | Descriptor: | S-ADENOSYLMETHIONINE, uncharacterized protein Q5LES9 | Authors: | Vorobiev, S, Neely, H, Seetharaman, J, Wang, D, Ciccosanti, C, Foote, E.L, Sahdev, S, Acton, T.B, Xiao, R, Everett, J.K, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2009-11-06 | Release date: | 2009-11-24 | Last modified: | 2017-10-25 | Method: | X-RAY DIFFRACTION (1.677 Å) | Cite: | Crystal structure of the Q5LES9_BACFN protein from Bacteroides fragilis. To be Published
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5L8V
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![BU of 5l8v by Molmil](/molmil-images/mine/5l8v) | Apo-structure of humanised RadA-mutant humRadA4 | Descriptor: | DNA repair and recombination protein RadA, PHOSPHATE ION | Authors: | Marsh, M, Fischer, G, Moschetti, T, Sharpe, T, Scott, D, Morgan, M, Ng, H, Skidmore, J, Venkitaraman, A, Abell, C, Blundell, T.L, Hyvonen, M. | Deposit date: | 2016-06-08 | Release date: | 2016-10-19 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Engineering Archeal Surrogate Systems for the Development of Protein-Protein Interaction Inhibitors against Human RAD51. J.Mol.Biol., 428, 2016
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5W3W
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![BU of 5w3w by Molmil](/molmil-images/mine/5w3w) | Crystal structure of SsoPox AsD6 mutant (V27A-Y97W-L228M-W263M) - open form | Descriptor: | 1,2-ETHANEDIOL, Aryldialkylphosphatase, COBALT (II) ION, ... | Authors: | Hiblot, J, Gotthard, G, Jacquet, P, Daude, D, Bergonzi, C, Chabriere, E, Elias, M. | Deposit date: | 2017-06-08 | Release date: | 2018-01-10 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Rational engineering of a native hyperthermostable lactonase into a broad spectrum phosphotriesterase. Sci Rep, 7, 2017
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8XAI
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![BU of 8xai by Molmil](/molmil-images/mine/8xai) | |
5LA5
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![BU of 5la5 by Molmil](/molmil-images/mine/5la5) | |
3KIP
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![BU of 3kip by Molmil](/molmil-images/mine/3kip) | Crystal structure of type-II 3-dehydroquinase from C. albicans | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 3-dehydroquinase, type II, ... | Authors: | Trapani, S, Schoehn, G, Navaza, J, Abergel, C. | Deposit date: | 2009-11-02 | Release date: | 2010-05-12 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Macromolecular crystal data phased by negative-stained electron-microscopy reconstructions. Acta Crystallogr.,Sect.D, 66, 2010
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4UVR
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![BU of 4uvr by Molmil](/molmil-images/mine/4uvr) | Binding mode, selectivity and potency of N-indolyl-oxopyridinyl-4- amino-propanyl-based inhibitors targeting Trypanosoma cruzi CYP51 | Descriptor: | Nalpha-{4-[4-(5-chloro-2-methylphenyl)piperazin-1-yl]-2-fluorobenzoyl}-N-pyridin-4-yl-D-tryptophanamide, PROTOPORPHYRIN IX CONTAINING FE, STEROL 14-DEMETHYLASE, ... | Authors: | Vieira, D.F, Choi, J.Y, Calvet, C.M, Gut, J, Kellar, D, Siqueira-Neto, J.L, Johnston, J.B, McKerrow, J.H, Roush, W.R, Podust, L.M. | Deposit date: | 2014-08-08 | Release date: | 2014-11-26 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.48 Å) | Cite: | Binding Mode and Potency of N-Indolyl-Oxopyridinyl-4-Amino-Propanyl-Based Inhibitors Targeting Trypanosoma Cruzi Cyp51 J.Med.Chem., 57, 2014
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5LAU
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![BU of 5lau by Molmil](/molmil-images/mine/5lau) | Oceanobacillus iheyensis macrodomain mutant G37V with ADPR | Descriptor: | GLYCEROL, MacroD-type macrodomain, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE | Authors: | Gil-Ortiz, F, Zapata-Perez, R, Martinez, A.B, Juanhuix, J, Sanchez-Ferrer, A. | Deposit date: | 2016-06-15 | Release date: | 2017-05-03 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | Structural and functional analysis of Oceanobacillus iheyensis macrodomain reveals a network of waters involved in substrate binding and catalysis. Open Biol, 7, 2017
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3KN3
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![BU of 3kn3 by Molmil](/molmil-images/mine/3kn3) | Crystal Structure of LysR Substrate Binding Domain (25-263) of Putative Periplasmic Protein from Wolinella succinogenes | Descriptor: | ACETIC ACID, CITRIC ACID, GLUTATHIONE, ... | Authors: | Kim, Y, Volkart, L, Bearden, J, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2009-11-11 | Release date: | 2009-12-01 | Last modified: | 2011-12-21 | Method: | X-RAY DIFFRACTION (2.412 Å) | Cite: | Crystal Structure of LysR Substrate Binding Domain from Wolinella succinogenes To be Published
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5LB4
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![BU of 5lb4 by Molmil](/molmil-images/mine/5lb4) | Apo-structure of humanised RadA-mutant humRadA14 | Descriptor: | DNA repair and recombination protein RadA | Authors: | Marsh, M, Fischer, G, Moschetti, T, Sharpe, T, Scott, D, Morgan, M, Ng, H, Skidmore, J, Venkitaraman, A, Abell, C, Blundell, T.L, Hyvonen, M. | Deposit date: | 2016-06-15 | Release date: | 2016-10-19 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.98 Å) | Cite: | Engineering Archeal Surrogate Systems for the Development of Protein-Protein Interaction Inhibitors against Human RAD51. J.Mol.Biol., 428, 2016
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5W59
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![BU of 5w59 by Molmil](/molmil-images/mine/5w59) | |
5W3S
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![BU of 5w3s by Molmil](/molmil-images/mine/5w3s) | Cryo-electron microscopy structure of a TRPML3 ion channel | Descriptor: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, CHOLESTEROL HEMISUCCINATE, Mucolipin-3 isoform 1, ... | Authors: | Hirschi, M, Herzik, M.A, Wie, J, Suo, Y, Borschel, W.F, Ren, D, Lander, G.C, Lee, S.Y. | Deposit date: | 2017-06-08 | Release date: | 2017-10-11 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (2.94 Å) | Cite: | Cryo-electron microscopy structure of the lysosomal calcium-permeable channel TRPML3. Nature, 550, 2017
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3KOJ
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![BU of 3koj by Molmil](/molmil-images/mine/3koj) | Crystal structure of the SSB domain of Q5N255_SYNP6 protein from Synechococcus sp. Northeast Structural Genomics Consortium Target SnR59a. | Descriptor: | uncharacterized protein ycf41 | Authors: | Vorobiev, S, Su, M, Seetharaman, J, Wang, H, Foote, L.E, Ciccosanti, C, Janjua, H, Xiao, R, Acton, T.B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2009-11-13 | Release date: | 2009-11-24 | Last modified: | 2021-10-13 | Method: | X-RAY DIFFRACTION (1.895 Å) | Cite: | Crystal structure of the SSB domain of Q5N255_SYNP6 protein from Synechococcus sp. To be Published
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5KKH
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![BU of 5kkh by Molmil](/molmil-images/mine/5kkh) | 2.1-Angstrom In situ Mylar structure of bacteriorhodopsin from Haloquadratum walsbyi (HwBR) at 100 K | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Bacteriorhodopsin-I, ... | Authors: | Broecker, J, Ernst, O.P. | Deposit date: | 2016-06-21 | Release date: | 2017-02-15 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.125 Å) | Cite: | A Versatile System for High-Throughput In Situ X-ray Screening and Data Collection of Soluble and Membrane-Protein Crystals. Cryst Growth Des, 16, 2016
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5L89
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![BU of 5l89 by Molmil](/molmil-images/mine/5l89) | Crystal structure of Rhodospirillum rubrum Rru_A0973 mutant E32A | Descriptor: | CALCIUM ION, Rru_A0973 | Authors: | He, D, Hughes, S, Vanden-Hehir, S, Georgiev, A, Altenbach, K, Tarrant, E, Mackay, C.L, Waldron, K.J, Clarke, D.J, Marles-Wright, J. | Deposit date: | 2016-06-07 | Release date: | 2016-08-31 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.59 Å) | Cite: | Structural characterization of encapsulated ferritin provides insight into iron storage in bacterial nanocompartments. Elife, 5, 2016
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4V6V
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![BU of 4v6v by Molmil](/molmil-images/mine/4v6v) | Tetracycline resistance protein Tet(O) bound to the ribosome | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Li, W, Atkinson, G.C, Thakor, N.S, Allas, U, Lu, C, Chan, K.Y, Tenson, T, Schulten, K, Wilson, K.S, Hauryliuk, V, Frank, J. | Deposit date: | 2013-02-25 | Release date: | 2014-07-09 | Last modified: | 2024-02-28 | Method: | ELECTRON MICROSCOPY (9.8 Å) | Cite: | Mechanism of tetracycline resistance by ribosomal protection protein Tet(O). Nat Commun, 4, 2013
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4V8W
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![BU of 4v8w by Molmil](/molmil-images/mine/4v8w) | Structure and conformational variability of the Mycobacterium tuberculosis fatty acid synthase multienzyme complex | Descriptor: | FLAVIN MONONUCLEOTIDE, TYPE-I FATTY ACID SYNTHASE | Authors: | Ciccarelli, L, Connell, S.R, Enderle, M, Mills, D.J, Vonck, J, Grininger, M. | Deposit date: | 2013-04-18 | Release date: | 2014-07-09 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (17.5 Å) | Cite: | Structure and Conformational Variability of the Mycobacterium Tuberculosis Fatty Acid Synthase Multienzyme Complex. Structure, 21, 2013
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3KNB
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![BU of 3knb by Molmil](/molmil-images/mine/3knb) | |
4TXL
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![BU of 4txl by Molmil](/molmil-images/mine/4txl) | Crystal structure of uridine phosphorylase from Schistosoma mansoni in complex with uracil | Descriptor: | SULFATE ION, URACIL, Uridine phosphorylase | Authors: | Marinho, A, Torini, J, Romanello, L, Cassago, A, DeMarco, R, Brandao-Neto, J, Pereira, H.M. | Deposit date: | 2014-07-03 | Release date: | 2015-07-15 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.92 Å) | Cite: | Analysis of two Schistosoma mansoni uridine phosphorylases isoforms suggests the emergence of a protein with a non-canonical function. Biochimie, 125, 2016
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3KSL
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![BU of 3ksl by Molmil](/molmil-images/mine/3ksl) | Structure of FPT bound to DATFP-DH-GPP | Descriptor: | (2S,6E)-8-{[(R)-hydroxy(phosphonooxy)phosphoryl]oxy}-2,6-dimethyloct-6-en-1-yl (2S)-3,3,3-trifluoro-2-hydrazinopropanoate, Farnesyltransferase, CAAX box, ... | Authors: | Hovlid, M.L, Edelstein, R.L, Henry, O, Ochocki, J, DeGraw, A, Lenevich, S, Talbot, T, Young, V, Hruza, A.W, Lopez-Gallego, F, Labello, N.P, Strickland, C.L, Schmidt-Dannert, C, Distefano, M.D. | Deposit date: | 2009-11-23 | Release date: | 2009-12-22 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Synthesis, properties, and applications of diazotrifluropropanoyl-containing photoactive analogs of farnesyl diphosphate containing modified linkages for enhanced stability. Chem.Biol.Drug Des., 75, 2010
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3KT6
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![BU of 3kt6 by Molmil](/molmil-images/mine/3kt6) | Crystal structure of S. cerevisiae tryptophanyl-tRNA synthetase in complex with Trp | Descriptor: | SULFATE ION, TRYPTOPHAN, Tryptophanyl-tRNA synthetase, ... | Authors: | Zhou, M, Dong, X, Zhong, C, Shen, N, Ding, J. | Deposit date: | 2009-11-24 | Release date: | 2010-02-16 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal structures of Saccharomyces cerevisiae tryptophanyl-tRNA synthetase: new insights into the mechanism of tryptophan activation and implications for anti-fungal drug design Nucleic Acids Res., 38, 2010
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5KQW
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![BU of 5kqw by Molmil](/molmil-images/mine/5kqw) | Directed Evolution of Transaminases By Ancestral Reconstruction. Using Old Proteins for New Chemistries | Descriptor: | 1,2-ETHANEDIOL, 4-aminobutyrate transaminase, DI(HYDROXYETHYL)ETHER, ... | Authors: | Wilding, M, Newman, J, Peat, T.S, Scott, C. | Deposit date: | 2016-07-06 | Release date: | 2017-07-12 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.23 Å) | Cite: | Reverse engineering: transaminase biocatalyst development using ancestral sequence reconstruction Green Chemistry, 19, 2017
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4UX9
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![BU of 4ux9 by Molmil](/molmil-images/mine/4ux9) | Crystal structure of JNK1 bound to a MKK7 docking motif | Descriptor: | DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 7, MITOGEN-ACTIVATED PROTEIN KINASE 8, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | Authors: | Kragelj, J, Palencia, A, Nanao, M.H, Maurin, D, Bouvignies, G, Blackledge, M, Ringkjobing-Jensen, M. | Deposit date: | 2014-08-20 | Release date: | 2015-03-25 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.34 Å) | Cite: | Structure and Dynamics of the Mkk7-Jnk Signaling Complex. Proc.Natl.Acad.Sci.USA, 112, 2015
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5LBI
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![BU of 5lbi by Molmil](/molmil-images/mine/5lbi) | Apo-structure of humanised RadA-mutant humRadA3 | Descriptor: | CALCIUM ION, DNA repair and recombination protein RadA | Authors: | Marsh, M, Fischer, G, Moschetti, T, Sharpe, T, Scott, D, Morgan, M, Ng, H, Skidmore, J, Venkitaraman, A, Abell, C, Blundell, T.L, Hyvonen, M. | Deposit date: | 2016-06-16 | Release date: | 2016-10-26 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.43 Å) | Cite: | Engineering Archeal Surrogate Systems for the Development of Protein-Protein Interaction Inhibitors against Human RAD51. J.Mol.Biol., 428, 2016
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