3KNE
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![BU of 3kne by Molmil](/molmil-images/mine/3kne) | Carbonic Anhydrase II H64C mutant in complex with an in situ formed triazole | 分子名称: | (4-CARBOXYPHENYL)(CHLORO)MERCURY, Carbonic anhydrase 2, N-[(S)-(1-{2-oxo-2-[(3-sulfanylpropyl)amino]ethyl}-1H-1,2,3-triazol-5-yl)(phenyl)methyl]-4-sulfamoylbenzamide, ... | 著者 | Schulze-Wischeler, J, Heine, A, Klebe, G. | 登録日 | 2009-11-12 | 公開日 | 2011-05-18 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | Stereo- and Regioselective Azide/Alkyne Cycloadditions in Carbonic Anhydrase II via Tethering, Monitored by Crystallography and Mass Spectrometry. Chemistry, 17, 2011
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7JVP
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![BU of 7jvp by Molmil](/molmil-images/mine/7jvp) | Cryo-EM structure of SKF-83959-bound dopamine receptor 1 in complex with Gs protein | 分子名称: | (1R)-6-chloro-3-methyl-1-(3-methylphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol, CHOLESTEROL, D(1A) dopamine receptor, ... | 著者 | Zhuang, Y, Xu, P, Mao, C, Wang, L, Krumm, B, Zhou, X.E, Huang, S, Liu, H, Cheng, X, Huang, X.-P, Sheng, D.-D, Xu, T, Liu, Y.-F, Wang, Y, Guo, J, Jiang, Y, Jiang, H, Melcher, K, Roth, B.L, Zhang, Y, Zhang, C, Xu, H.E. | 登録日 | 2020-08-22 | 公開日 | 2021-02-24 | 最終更新日 | 2021-03-03 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structural insights into the human D1 and D2 dopamine receptor signaling complexes. Cell, 184, 2021
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7JQG
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5B1U
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5KQW
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![BU of 5kqw by Molmil](/molmil-images/mine/5kqw) | Directed Evolution of Transaminases By Ancestral Reconstruction. Using Old Proteins for New Chemistries | 分子名称: | 1,2-ETHANEDIOL, 4-aminobutyrate transaminase, DI(HYDROXYETHYL)ETHER, ... | 著者 | Wilding, M, Newman, J, Peat, T.S, Scott, C. | 登録日 | 2016-07-06 | 公開日 | 2017-07-12 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.23 Å) | 主引用文献 | Reverse engineering: transaminase biocatalyst development using ancestral sequence reconstruction Green Chemistry, 19, 2017
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5BNJ
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![BU of 5bnj by Molmil](/molmil-images/mine/5bnj) | CDK8/CYCC IN COMPLEX WITH 8-{3-Chloro-5-[4-(1-methyl-1H-pyrazol-4-yl)-phenyl]-pyridin- 4-yl}-2,8-diaza-spiro[4.5]decan-1-one | 分子名称: | 8-{3-chloro-5-[4-(1-methyl-1H-pyrazol-4-yl)phenyl]pyridin-4-yl}-2,8-diazaspiro[4.5]decan-1-one, Cyclin-C, Cyclin-dependent kinase 8, ... | 著者 | Musil, D, Blagg, J, Wienke, D. | 登録日 | 2015-05-26 | 公開日 | 2015-10-14 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.64 Å) | 主引用文献 | A selective chemical probe for exploring the role of CDK8 and CDK19 in human disease. Nat.Chem.Biol., 11, 2015
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3ATK
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![BU of 3atk by Molmil](/molmil-images/mine/3atk) | Crystal structure of trypsin complexed with cycloheptanamine | 分子名称: | CALCIUM ION, Cationic trypsin, DIMETHYL SULFOXIDE, ... | 著者 | Yamane, J, Yao, M, Tanaka, I. | 登録日 | 2011-01-05 | 公開日 | 2011-08-24 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.74 Å) | 主引用文献 | In-crystal affinity ranking of fragment hit compounds reveals a relationship with their inhibitory activities J.Appl.Crystallogr., 44, 2011
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5KRO
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![BU of 5kro by Molmil](/molmil-images/mine/5kro) | Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with the Methyl(phenyl)amino-substituted Estrogen, (8R,9S,13S,14S,17S)-13-methyl-17-(methyl(phenyl)amino)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-ol | 分子名称: | (8~{R},9~{S},13~{S},14~{S},17~{S})-13-methyl-17-[methyl(phenyl)amino]-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-ol, Estrogen receptor, NCOA2 | 著者 | Nwachukwu, J.C, Srinivasan, S, Bruno, N.E, Nowak, J, Kojetin, D.J, Elemento, O, Katzenellenbogen, J.A, Nettles, K.W. | 登録日 | 2016-07-07 | 公開日 | 2017-01-18 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies. Cell Chem Biol, 24, 2017
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7JV5
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![BU of 7jv5 by Molmil](/molmil-images/mine/7jv5) | Cryo-EM structure of SKF-81297-bound dopamine receptor 1 in complex with Gs protein | 分子名称: | (1R)-6-chloro-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol, CHOLESTEROL, D(1A) dopamine receptor, ... | 著者 | Zhuang, Y, Xu, P, Mao, C, Wang, L, Krumm, B, Zhou, X.E, Huang, S, Liu, H, Cheng, X, Huang, X.-P, Sheng, D.-D, Xu, T, Liu, Y.-F, Wang, Y, Guo, J, Jiang, Y, Jiang, H, Melcher, K, Roth, B.L, Zhang, Y, Zhang, C, Xu, H.E. | 登録日 | 2020-08-20 | 公開日 | 2021-02-24 | 最終更新日 | 2021-03-03 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural insights into the human D1 and D2 dopamine receptor signaling complexes. Cell, 184, 2021
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5BPW
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3CAM
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5L89
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![BU of 5l89 by Molmil](/molmil-images/mine/5l89) | Crystal structure of Rhodospirillum rubrum Rru_A0973 mutant E32A | 分子名称: | CALCIUM ION, Rru_A0973 | 著者 | He, D, Hughes, S, Vanden-Hehir, S, Georgiev, A, Altenbach, K, Tarrant, E, Mackay, C.L, Waldron, K.J, Clarke, D.J, Marles-Wright, J. | 登録日 | 2016-06-07 | 公開日 | 2016-08-31 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.59 Å) | 主引用文献 | Structural characterization of encapsulated ferritin provides insight into iron storage in bacterial nanocompartments. Elife, 5, 2016
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5B6L
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![BU of 5b6l by Molmil](/molmil-images/mine/5b6l) | Structure of Deg protease HhoA from Synechocystis sp. PCC 6803 | 分子名称: | Putative serine protease HhoA, SODIUM ION, UNK-UNK-UNK-UNK-TRP, ... | 著者 | Dong, W, Wang, J, Liu, L. | 登録日 | 2016-05-30 | 公開日 | 2016-09-21 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.801 Å) | 主引用文献 | Crystal structure of the zinc-bound HhoA protease from Synechocystis sp. PCC 6803 Febs Lett., 590, 2016
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7JSK
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![BU of 7jsk by Molmil](/molmil-images/mine/7jsk) | Structure of the NaCT-Citrate complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CITRIC ACID, SODIUM ION, ... | 著者 | Sauer, D.B, Wang, B, Song, J, Rice, W.J, Wang, D.N. | 登録日 | 2020-08-14 | 公開日 | 2021-02-24 | 最終更新日 | 2021-03-10 | 実験手法 | ELECTRON MICROSCOPY (3.04 Å) | 主引用文献 | Structure and inhibition mechanism of the human citrate transporter NaCT. Nature, 591, 2021
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5E3H
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![BU of 5e3h by Molmil](/molmil-images/mine/5e3h) | Structural Basis for RNA Recognition and Activation of RIG-I | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, GLYCEROL, ... | 著者 | Jiang, F, Miller, M.T, Marcotrigiano, J. | 登録日 | 2015-10-02 | 公開日 | 2015-11-18 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structural basis of RNA recognition and activation by innate immune receptor RIG-I. Nature, 479, 2011
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1IHJ
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7JVR
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![BU of 7jvr by Molmil](/molmil-images/mine/7jvr) | Cryo-EM structure of Bromocriptine-bound dopamine receptor 2 in complex with Gi protein | 分子名称: | Antibody fragment ScFv16, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Zhuang, Y, Xu, P, Mao, C, Wang, L, Krumm, B, Zhou, X.E, Huang, S, Liu, H, Cheng, X, Huang, X.-P, Sheng, D.-D, Xu, T, Liu, Y.-F, Wang, Y, Guo, J, Jiang, Y, Jiang, H, Melcher, K, Roth, B.L, Zhang, Y, Zhang, C, Xu, H.E. | 登録日 | 2020-08-22 | 公開日 | 2021-02-24 | 最終更新日 | 2021-03-31 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Structural insights into the human D1 and D2 dopamine receptor signaling complexes. Cell, 184, 2021
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7JMK
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5LBI
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![BU of 5lbi by Molmil](/molmil-images/mine/5lbi) | Apo-structure of humanised RadA-mutant humRadA3 | 分子名称: | CALCIUM ION, DNA repair and recombination protein RadA | 著者 | Marsh, M, Fischer, G, Moschetti, T, Sharpe, T, Scott, D, Morgan, M, Ng, H, Skidmore, J, Venkitaraman, A, Abell, C, Blundell, T.L, Hyvonen, M. | 登録日 | 2016-06-16 | 公開日 | 2016-10-26 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.43 Å) | 主引用文献 | Engineering Archeal Surrogate Systems for the Development of Protein-Protein Interaction Inhibitors against Human RAD51. J.Mol.Biol., 428, 2016
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5DM9
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5KKK
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1UT2
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![BU of 1ut2 by Molmil](/molmil-images/mine/1ut2) | AfaE-3 adhesin from Escherichia Coli | 分子名称: | AFIMBRIAL ADHESIN AFA-III, SULFATE ION | 著者 | Anderson, K.L, Billington, J, Pettigrew, D, Cota, E, Roversi, P, Simpson, P, Chen, H.A, Urvil, P, Dumerle, L, Barlow, P, Medof, E, Smith, R.A.G, Nowicki, B, Le Bouguenec, C, Lea, S.M, Matthews, S. | 登録日 | 2003-12-02 | 公開日 | 2004-08-31 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | High Resolution Studies of the Afa/Dr Adhesin Drae and its Interaction with Chloramphenicol J.Biol.Chem., 279, 2004
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5E8E
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![BU of 5e8e by Molmil](/molmil-images/mine/5e8e) | Crystal structure of thrombin bound to an exosite 1-specific IgA Fab | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CITRIC ACID, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, ... | 著者 | Baglin, T.P, Langdown, J, Frasson, R, Huntington, J.A. | 登録日 | 2015-10-14 | 公開日 | 2015-10-28 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Discovery and characterization of an antibody directed against exosite I of thrombin. J.Thromb.Haemost., 14, 2016
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1IE1
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![BU of 1ie1 by Molmil](/molmil-images/mine/1ie1) | NMR Solution Structure of an In Vitro Selected RNA which is Sequence Specifically Recognized by Hamster Nucleolin RBD12. | 分子名称: | 5'-R(*GP*GP*CP*CP*GP*AP*AP*AP*UP*CP*CP*CP*GP*AP*AP*GP*UP*AP*GP*GP*CP*C)-3' | 著者 | Bouvet, P, Allain, F.H.-T, Finger, L.D, Dieckmann, T, Feigon, J. | 登録日 | 2001-04-05 | 公開日 | 2001-06-20 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Recognition of pre-formed and flexible elements of an RNA stem-loop by nucleolin. J.Mol.Biol., 309, 2001
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5E93
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![BU of 5e93 by Molmil](/molmil-images/mine/5e93) | Crystal Structure of Trypanosoma cruzi Dihydroorotate Dehydrogenase in Complex with Neq0071 | 分子名称: | 1,2-ETHANEDIOL, 5-[(E)-3-(furan-2-yl)prop-2-enylidene]-1,3-diazinane-2,4,6-trione, CACODYLATE ION, ... | 著者 | Rocha, J.R, Inaoka, D.K, Cheleski, J, Shiba, T, Harada, S, Montanari, C.A, Kita, K. | 登録日 | 2015-10-14 | 公開日 | 2016-10-19 | 最終更新日 | 2020-02-19 | 実験手法 | X-RAY DIFFRACTION (1.41 Å) | 主引用文献 | Exploring Trypanosoma cruzi Dihydroorotate Dehydrogenase Active Site Plasticity for the Discovery of Potent and Selective Inhibitors with Trypanocidal Activity To be Published
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