5E8E

Crystal structure of thrombin bound to an exosite 1-specific IgA Fab

Summary for 5E8E

Entry DOI	10.2210/pdb5e8e/pdb
Related PRD ID	PRD_000020
Descriptor	IGA FAB LIGHT CHAIN, SODIUM ION, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, ... (12 entities in total)
Functional Keywords	immune system-hydrolase complex, immune system, inhibitor, immune system/hydrolase
Biological source	Homo sapiens (HUMAN) More
Total number of polymer chains	4
Total formula weight	85481.57
Authors	Baglin, T.P.,Langdown, J.,Frasson, R.,Huntington, J.A. (deposition date: 2015-10-14, release date: 2015-10-28, Last modification date: 2024-11-06)
Primary citation	Baglin, T.P.,Langdown, J.,Frasson, R.,Huntington, J.A. Discovery and characterization of an antibody directed against exosite I of thrombin. J.Thromb.Haemost., 14:137-142, 2016 Cited by PubMed Abstract: ESSENTIALS: An IgA paraprotein with anti-thrombin activity was not associated with a severe bleeding phenotype. This observation challenges the paradigm that anticoagulant therapy necessarily increases bleeding risk. Characterization of the antibody showed that it specifically binds to thrombin exosite I. A therapeutic drug with the properties of this antibody might be an antithrombotic that doesn't cause bleeding. PubMed: 26469093 DOI: 10.1111/jth.13171 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation