5E8E

Crystal structure of thrombin bound to an exosite 1-specific IgA Fab

Summary for 5E8E

Related PRD IDPRD_000020
DescriptorIGA FAB LIGHT CHAIN, IGA FAB HEAVY CHAIN, THROMBIN HEAVY CHAIN, ... (15 entities in total)
Functional Keywordsimmune system-hydrolase complex, immune system, inhibitor, immune system/hydrolase
Biological sourceHomo sapiens (HUMAN)
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Cellular locationSecreted, extracellular space P00734 P00734
Total number of polymer chains4
Total molecular weight85607.68
Authors
Baglin, T.P.,Langdown, J.,Frasson, R.,Huntington, J.A. (deposition date: 2015-10-14, release date: 2015-10-28, Last modification date: 2016-01-27)
Primary citation
Baglin, T.P.,Langdown, J.,Frasson, R.,Huntington, J.A.
Discovery and characterization of an antibody directed against exosite I of thrombin.
J.Thromb.Haemost., 14:137-142, 2016
PubMed: 26469093 (PDB entries with the same primary citation)
DOI: 10.1111/jth.13171
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.9 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.246902.1%0.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution