5E8E

Crystal structure of thrombin bound to an exosite 1-specific IgA Fab

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	IGA FAB LIGHT CHAIN	polymer	215	23544.3	1		Homo sapiens (HUMAN)
2	B (B)	IGA FAB HEAVY CHAIN	polymer	229	24768.6	1		Homo sapiens (HUMAN)
3	C (H)	THROMBIN HEAVY CHAIN	polymer	259	29780.2	1	UniProt (P00734) Pfam (PF00089)	Homo sapiens (Human)	Coagulation factor II
4	D (L)	THROMBIN LIGHT CHAIN	polymer	36	4096.5	1	UniProt (P00734) Pfam (PF09396)	Homo sapiens (Human)	Coagulation factor II
5	E (C)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G42666HT)
6	F (D)	N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		1405.3	1	In PDB GlyTouCan (G08394CG)
7	G, J, Q (A, H)	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	3	Chemie (PEG)
8	H, L, M, N, O (B, H)	PHOSPHATE ION	non-polymer		95.0	5	Chemie (PO4)
9	I (H)	CITRIC ACID	non-polymer		192.1	1	Chemie (CIT)
10	K (H)	SODIUM ION	non-polymer		23.0	1	Chemie (NA)
11	P (H)	D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide	non-polymer		454.0	1	BIRD (PRD_000020) Chemie (0G6)
12	R, S, T, U (A, B, H, L)	water	water		18.0	407	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	82189.6
Branched	Number of molecules	2
	Total formula weight	1829.7
Non-Polymers*	Number of molecules	11
	Total formula weight	1462.3
All*	Total formula weight	85481.6

*Water molecules are not included.