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PDB: 104 件
3RF3
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BU of 3rf3 by Molmil
Shigella IpaA-VBS3 in complex with human vinculin
分子名称: CACODYLATE ION, Invasin ipaA, Vinculin
著者Park, H, Sharff, A, Izard, T.
登録日2011-04-05
公開日2011-04-27
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.61 Å)
主引用文献Novel vinculin binding site of the IpaA invasin of Shigella.
J.Biol.Chem., 286, 2011
3S90
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BU of 3s90 by Molmil
Human vinculin head domain Vh1 (residues 1-252) in complex with murine talin (VBS33; residues 1512-1546)
分子名称: Talin-1, Vinculin
著者Yogesha, S.D, Sharff, A, Bricogne, G, Izard, T.
登録日2011-05-31
公開日2011-06-22
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.97 Å)
主引用文献Intermolecular versus intramolecular interactions of the vinculin binding site 33 of talin.
Protein Sci., 20, 2011
3SMZ
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BU of 3smz by Molmil
Human raver1 RRM1-3 domains (residues 39-320)
分子名称: Ribonucleoprotein PTB-binding 1, SULFATE ION
著者Rangarajan, E.S, Lee, J.H, Izard, T.
登録日2011-06-28
公開日2011-08-10
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.99 Å)
主引用文献Apo raver1 structure reveals distinct RRM domain orientations.
Protein Sci., 20, 2011
3TJ5
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BU of 3tj5 by Molmil
human vinculin head domain (Vh1, residues 1-258) in complex with the vinculin binding site of the surface cell antigen 4 (sca4-VBS-N; residues 412-434) from Rickettsia rickettsii
分子名称: Antigenic heat-stable 120 kDa protein, GLYCEROL, Vinculin
著者Park, H, Lee, J.H, Gouin, E, Cossart, P, Izard, T.
登録日2011-08-23
公開日2011-09-07
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.99 Å)
主引用文献The rickettsia surface cell antigen 4 applies mimicry to bind to and activate vinculin.
J.Biol.Chem., 286, 2011
3U8Z
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BU of 3u8z by Molmil
human merlin FERM domain
分子名称: Merlin
著者Yogesha, S.D, Sharff, A.J, Giovannini, M, Bricogne, G, Izard, T.
登録日2011-10-17
公開日2011-11-02
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.64 Å)
主引用文献Unfurling of the band 4.1, ezrin, radixin, moesin (FERM) domain of the merlin tumor suppressor.
Protein Sci., 20, 2011
3TJ6
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BU of 3tj6 by Molmil
human vinculin head domain (Vh1, residues 1-258) in complex with the vinculin binding site of the surface cell antigen 4 (sca4-VBS-C; residues 812-835) from Rickettsia rickettsii
分子名称: Antigenic heat-stable 120 kDa protein, Vinculin
著者Park, H, Lee, J.H, Gouin, E, Cossart, P, Izard, T.
登録日2011-08-23
公開日2011-09-07
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.76 Å)
主引用文献The rickettsia surface cell antigen 4 applies mimicry to bind to and activate vinculin.
J.Biol.Chem., 286, 2011
7RS3
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BU of 7rs3 by Molmil
Crystal Structure of the ER-alpha Ligand-binding Domain (L372S, L536S) in complex with DMERI-29
分子名称: (1S,2R,4S)-6-[4-(benzyloxy)phenyl]-5-(4-hydroxyphenyl)-N-(4-methoxyphenyl)-N-(2,2,2-trifluoroethyl)-7-oxabicyclo[2.2.1]hept-5-ene-2-sulfonamide, CYSTEINE, Estrogen receptor, ...
著者Min, J, Nwachukwu, J.C, Min, C.K, Njeri, J.W, Srinivasan, S, Rangarajan, E.S, Nettles, C.C, Yan, S, Houtman, R, Griffin, P.R, Izard, T, Katzenellenbogen, B.S, Katzenellenbogen, J.A, Nettles, K.W.
登録日2021-08-10
公開日2021-09-08
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.84 Å)
主引用文献Dual-mechanism estrogen receptor inhibitors.
Proc.Natl.Acad.Sci.USA, 118, 2021
7RS0
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BU of 7rs0 by Molmil
Crystal Structure of the ER-alpha Ligand-binding Domain (L372S, L536S) in complex with DMERI-18
分子名称: (1R,2S,4R,5R,6R)-5-(4-hydroxyphenyl)-N-(4-methoxyphenyl)-6-(4-propoxyphenyl)-N-(2,2,2-trifluoroethyl)-7-oxabicyclo[2.2.1]heptane-2-sulfonamide, Estrogen receptor
著者Min, J, Nwachukwu, J.C, Min, C.K, Njeri, J.W, Srinivasan, S, Rangarajan, E.S, Nettles, C.C, Yan, S, Houtman, R, Griffin, P.R, Izard, T, Katzenellenbogen, B.S, Katzenellenbogen, J.A, Nettles, K.W.
登録日2021-08-10
公開日2021-09-08
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.67 Å)
主引用文献Dual-mechanism estrogen receptor inhibitors.
Proc.Natl.Acad.Sci.USA, 118, 2021
7RS1
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BU of 7rs1 by Molmil
Crystal Structure of the ER-alpha Ligand-binding Domain (L372S, L536S) in complex with DMERI-21
分子名称: Estrogen receptor, methyl 3-(4-{[(1S,2R,4S)-5,6-bis(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hept-5-ene-2-sulfonyl](2,2,2-trifluoroethyl)amino}phenyl)prop-2-enoate
著者Min, J, Nwachukwu, J.C, Min, C.K, Njeri, J.W, Srinivasan, S, Rangarajan, E.S, Nettles, C.C, Yan, S, Houtman, R, Griffin, P.R, Izard, T, Katzenellenbogen, B.S, Katzenellenbogen, J.A, Nettles, K.W.
登録日2021-08-10
公開日2021-09-08
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.59 Å)
主引用文献Dual-mechanism estrogen receptor inhibitors.
Proc.Natl.Acad.Sci.USA, 118, 2021
7RRZ
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BU of 7rrz by Molmil
Crystal Structure of the ER-alpha Ligand-binding Domain (L372S, L536S) in complex with DMERI-30
分子名称: (1S,2R,4S,5R,6S)-5-(4-hydroxyphenyl)-N-(4-methoxyphenyl)-6-{4-[3-(piperidin-1-yl)propoxy]phenyl}-N-(2,2,2-trifluoroethyl)-7-oxabicyclo[2.2.1]heptane-2-sulfonamide, Estrogen receptor
著者Min, J, Nwachukwu, J.C, Min, C.K, Njeri, J.W, Srinivasan, S, Rangarajan, E.S, Nettles, C.C, Yan, S, Houtman, R, Griffin, P.R, Izard, T, Katzenellenbogen, B.S, Katzenellenbogen, J.A, Nettles, K.W.
登録日2021-08-10
公開日2021-09-08
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.83 Å)
主引用文献Dual-mechanism estrogen receptor inhibitors.
Proc.Natl.Acad.Sci.USA, 118, 2021
7RS2
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BU of 7rs2 by Molmil
Crystal Structure of the ER-alpha Ligand-binding Domain (L372S, L536S) in complex with DMERI-23
分子名称: (2E)-3-(4-{[(1S,2R,4S,5S,6S)-5,6-bis(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]heptane-2-sulfonyl](2,2,2-trifluoroethyl)amino}phenyl)prop-2-enoic acid, Estrogen receptor
著者Min, J, Nwachukwu, J.C, Min, C.K, Njeri, J.W, Srinivasan, S, Rangarajan, E.S, Nettles, C.C, Yan, S, Houtman, R, Griffin, P.R, Izard, T, Katzenellenbogen, B.S, Katzenellenbogen, J.A, Nettles, K.W.
登録日2021-08-10
公開日2021-09-08
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.72 Å)
主引用文献Dual-mechanism estrogen receptor inhibitors.
Proc.Natl.Acad.Sci.USA, 118, 2021
7RS4
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BU of 7rs4 by Molmil
Crystal Structure of the ER-alpha Ligand-binding Domain (L372S, L536S) in complex with DMERI-8
分子名称: (2E)-3-{4-[(1E)-2-(2-chloro-4-fluorophenyl)-1-(2H-indazol-5-yl)but-1-en-1-yl]phenyl}prop-2-enoic acid, CHLORIDE ION, Estrogen receptor
著者Min, J, Nwachukwu, J.C, Min, C.K, Njeri, J.W, Srinivasan, S, Rangarajan, E.S, Nettles, C.C, Yan, S, Houtman, R, Griffin, P.R, Izard, T, Katzenellenbogen, B.S, Katzenellenbogen, J.A, Nettles, K.W.
登録日2021-08-10
公開日2021-09-08
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.78 Å)
主引用文献Dual-mechanism estrogen receptor inhibitors.
Proc.Natl.Acad.Sci.USA, 118, 2021
7RRY
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BU of 7rry by Molmil
Crystal Structure of the ER-alpha Ligand-binding Domain (L372S, L536S) in complex with DMERI-20
分子名称: (1S,2R,4S,5S,6S)-5,6-bis(4-hydroxyphenyl)-N-{4-[3-(piperidin-1-yl)propoxy]phenyl}-N-(2,2,2-trifluoroethyl)-7-oxabicyclo[2.2.1]heptane-2-sulfonamide, CHLORIDE ION, Estrogen receptor
著者Min, J, Nwachukwu, J.C, Min, C.K, Njeri, J.W, Srinivasan, S, Rangarajan, E.S, Nettles, C.C, Yan, S, Houtman, R, Griffin, P.R, Izard, T, Katzenellenbogen, B.S, Katzenellenbogen, J.A, Nettles, K.W.
登録日2021-08-10
公開日2021-09-08
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.87 Å)
主引用文献Dual-mechanism estrogen receptor inhibitors.
Proc.Natl.Acad.Sci.USA, 118, 2021
7RS9
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BU of 7rs9 by Molmil
Crystal Structure of the ER-alpha Ligand-binding Domain (L372S, L536S) in complex with DMERI-25
分子名称: (1S,2R,4S)-N-[4-(benzyloxy)phenyl]-5,6-bis(4-hydroxyphenyl)-N-(2,2,2-trifluoroethyl)-7-oxabicyclo[2.2.1]hept-5-ene-2-sulfonamide, Estrogen receptor
著者Min, J, Nwachukwu, J.C, Min, C.K, Njeri, J.W, Srinivasan, S, Rangarajan, E.S, Nettles, C.C, Yan, S, Houtman, R, Griffin, P.R, Izard, T, Katzenellenbogen, B.S, Katzenellenbogen, J.A, Nettles, K.W.
登録日2021-08-11
公開日2021-09-08
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Dual-mechanism estrogen receptor inhibitors.
Proc.Natl.Acad.Sci.USA, 118, 2021
7RS7
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BU of 7rs7 by Molmil
Crystal Structure of the ER-alpha Ligand-binding Domain (L372S, L536S) in complex with DMERI-30
分子名称: (1S,2R,4S,5S,6S)-N,5,6-tris(4-hydroxyphenyl)-N-(2,2,2-trifluoroethyl)-7-oxabicyclo[2.2.1]heptane-2-sulfonamide, Estrogen receptor
著者Min, J, Nwachukwu, J.C, Min, C.K, Njeri, J.W, Srinivasan, S, Rangarajan, E.S, Nettles, C.C, Yan, S, Houtman, R, Griffin, P.R, Izard, T, Katzenellenbogen, B.S, Katzenellenbogen, J.A, Nettles, K.W.
登録日2021-08-11
公開日2021-09-22
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.58 Å)
主引用文献Dual-mechanism estrogen receptor inhibitors.
Proc.Natl.Acad.Sci.USA, 118, 2021
7RRX
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BU of 7rrx by Molmil
Crystal Structure of the ER-alpha Ligand-binding Domain (L372S, L536S) in complex with DMERI-19
分子名称: (1S,2R,4S)-5,6-bis(4-hydroxyphenyl)-N-{4-[2-(piperidin-1-yl)ethoxy]phenyl}-N-(2,2,2-trifluoroethyl)-7-oxabicyclo[2.2.1]hept-5-ene-2-sulfonamide, CHLORIDE ION, Estrogen receptor
著者Min, J, Nwachukwu, J.C, Min, C.K, Njeri, J.W, Srinivasan, S, Rangarajan, E.S, Nettles, C.C, Yan, S, Houtman, R, Griffin, P.R, Izard, T, Katzenellenbogen, B.S, Katzenellenbogen, J.A, Nettles, K.W.
登録日2021-08-10
公開日2021-09-22
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.78 Å)
主引用文献Dual-mechanism estrogen receptor inhibitors.
Proc.Natl.Acad.Sci.USA, 118, 2021
7RS8
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BU of 7rs8 by Molmil
Crystal Structure of the ER-alpha Ligand-binding Domain (L372S, L536S) in complex with DMERI-16
分子名称: (1R,2S,4R)-5-(4-hydroxyphenyl)-N-(4-methoxyphenyl)-6-{4-[2-(piperidin-1-yl)ethoxy]phenyl}-N-(2,2,2-trifluoroethyl)-7-oxabicyclo[2.2.1]hept-5-ene-2-sulfonamide, Estrogen receptor
著者Min, J, Nwachukwu, J.C, Min, C.K, Njeri, J.W, Srinivasan, S, Rangarajan, E.S, Nettles, C.C, Yan, S, Houtman, R, Griffin, P.R, Izard, T, Katzenellenbogen, B.S, Katzenellenbogen, J.A, Nettles, K.W.
登録日2021-08-11
公開日2021-09-22
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.64 Å)
主引用文献Dual-mechanism estrogen receptor inhibitors.
Proc.Natl.Acad.Sci.USA, 118, 2021
1TR2
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BU of 1tr2 by Molmil
Crystal structure of human full-length vinculin (residues 1-1066)
分子名称: VINCULIN ISOFORM 1
著者Borgon, R.A, Vonrhein, C, Bricogne, G, Bois, P.R, Izard, T.
登録日2004-06-19
公開日2005-11-15
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Crystal Structure of Human Vinculin
Structure, 12, 2004
1TFU
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BU of 1tfu by Molmil
phosphopantetheine adenylyltransferase from Mycobacterium tuberculosis
分子名称: Phosphopantetheine adenylyltransferase
著者Morris, V.K, Izard, T, TB Structural Genomics Consortium (TBSGC)
登録日2004-05-27
公開日2004-09-14
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.99 Å)
主引用文献Substrate-induced asymmetry and channel closure revealed by the apoenzyme structure of Mycobacterium tuberculosis phosphopantetheine adenylyltransferase.
Protein Sci., 13, 2004
5L0C
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BU of 5l0c by Molmil
Human metavinculin (residues 959-1134) in complex with PIP2
分子名称: PHOSPHATE ION, Vinculin, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate
著者Chinthalapudi, K, Izard, T.
登録日2016-07-27
公開日2016-08-31
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Differential lipid binding of vinculin isoforms promotes quasi-equivalent dimerization.
Proc.Natl.Acad.Sci.USA, 113, 2016
5L0F
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BU of 5l0f by Molmil
Human metavinculin quadruple mutant (residues 959-1134)
分子名称: GLYCEROL, Vinculin
著者Chinthalapudi, K, Izard, T.
登録日2016-07-27
公開日2016-08-31
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.76 Å)
主引用文献Differential lipid binding of vinculin isoforms promotes quasi-equivalent dimerization.
Proc.Natl.Acad.Sci.USA, 113, 2016
5L0G
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BU of 5l0g by Molmil
Human metavinculin MVt Q971R, R975D, T978R mutant (residues 959-1134) in complex with PIP2
分子名称: Vinculin, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate
著者Chinthalapudi, K, Izard, T.
登録日2016-07-27
公開日2016-08-31
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献Differential lipid binding of vinculin isoforms promotes quasi-equivalent dimerization.
Proc.Natl.Acad.Sci.USA, 113, 2016
5L0D
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BU of 5l0d by Molmil
Human Metavinculin(residues 959-1130) in complex with PIP2
分子名称: Vinculin, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate
著者Chinthalapudi, K, Izard, T.
登録日2016-07-27
公開日2016-08-31
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Differential lipid binding of vinculin isoforms promotes quasi-equivalent dimerization.
Proc.Natl.Acad.Sci.USA, 113, 2016
5L0H
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BU of 5l0h by Molmil
Human metavinculin MVt cardiomyopathy-associated mutant R975W (residues 959-1134) in complex with PIP2
分子名称: DI(HYDROXYETHYL)ETHER, PHOSPHATE ION, Vinculin, ...
著者Chinthalapudi, K, Izard, T.
登録日2016-07-27
公開日2016-08-31
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Differential lipid binding of vinculin isoforms promotes quasi-equivalent dimerization.
Proc.Natl.Acad.Sci.USA, 113, 2016
5L0I
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BU of 5l0i by Molmil
Human metavinculin MVt R975W cardiomyopathy-associated mutant (residues 959-1134)
分子名称: GLYCEROL, SODIUM ION, Vinculin
著者Chinthalapudi, K, Izard, T.
登録日2016-07-27
公開日2016-08-31
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Differential lipid binding of vinculin isoforms promotes quasi-equivalent dimerization.
Proc.Natl.Acad.Sci.USA, 113, 2016

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