7RS3

Crystal Structure of the ER-alpha Ligand-binding Domain (L372S, L536S) in complex with DMERI-29

Summary for 7RS3

• Entry DOI: 10.2210/pdb7rs3/pdb
• Descriptor: Estrogen receptor, (1S,2R,4S)-6-[4-(benzyloxy)phenyl]-5-(4-hydroxyphenyl)-N-(4-methoxyphenyl)-N-(2,2,2-trifluoroethyl)-7-oxabicyclo[2.2.1]hept-5-ene-2-sulfonamide, TYROSINE, ... (6 entities in total)
• Functional Keywords: er-alpha, ligand complex, dmeri, transcription-transcription inhibitor complex, transcription/transcription inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 120661.37

Authors

Min, J.,Nwachukwu, J.C.,Min, C.K.,Njeri, J.W.,Srinivasan, S.,Rangarajan, E.S.,Nettles, C.C.,Yan, S.,Houtman, R.,Griffin, P.R.,Izard, T.,Katzenellenbogen, B.S.,Katzenellenbogen, J.A.,Nettles, K.W. (deposition date: 2021-08-10, release date: 2021-09-08, Last modification date: 2023-10-18)

• Primary citation: Min, J.,Nwachukwu, J.C.,Min, C.K.,Njeri, J.W.,Srinivasan, S.,Rangarajan, E.S.,Nettles, C.C.,Sanabria Guillen, V.,Ziegler, Y.,Yan, S.,Carlson, K.E.,Hou, Y.,Kim, S.H.,Novick, S.,Pascal, B.D.,Houtman, R.,Griffin, P.R.,Izard, T.,Katzenellenbogen, B.S.,Katzenellenbogen, J.A.,Nettles, K.W.; Dual-mechanism estrogen receptor inhibitors.; Proc.Natl.Acad.Sci.USA, 118:-, 2021; PubMed: 34452998; DOI: 10.1073/pnas.2101657118

Experimental method

X-RAY DIFFRACTION (1.84 Å)