7RS3
Crystal Structure of the ER-alpha Ligand-binding Domain (L372S, L536S) in complex with DMERI-29
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Estrogen receptor | polymer | 257 | 29380.5 | 4 | UniProt (P03372) Pfam (PF00104) | Homo sapiens (Human) | ER,ER-alpha,Estradiol receptor,Nuclear receptor subfamily 3 group A member 1 |
| 2 | E, I, K, L (A, B, C, D) | (1S,2R,4S)-6-[4-(benzyloxy)phenyl]-5-(4-hydroxyphenyl)-N-(4-methoxyphenyl)-N-(2,2,2-trifluoroethyl)-7-oxabicyclo[2.2.1]hept-5-ene-2-sulfonamide | non-polymer | 637.7 | 4 | Chemie (7OR) | |||
| 3 | F, J (B, C) | TYROSINE | non-polymer | 181.2 | 2 | Chemie (TYR) | |||
| 4 | G (B) | SERINE | non-polymer | 105.1 | 1 | Chemie (SER) | |||
| 5 | H (B) | CYSTEINE | non-polymer | 121.2 | 1 | Chemie (CYS) | |||
| 6 | M, N, O, P (A, B, C, D) | water | water | 18.0 | 71 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 298 - 554 (UniProt: P03372)
| PDB | External Database | Details |
|---|---|---|
| Ser 372 | Leu 372 | engineered mutation |
| Ser 536 | Leu 536 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 117522.1 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 3139.3 | |
| All* | Total formula weight | 120661.4 |
