7RS1
Crystal Structure of the ER-alpha Ligand-binding Domain (L372S, L536S) in complex with DMERI-21
Summary for 7RS1
Entry DOI | 10.2210/pdb7rs1/pdb |
Descriptor | Estrogen receptor, methyl 3-(4-{[(1S,2R,4S)-5,6-bis(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hept-5-ene-2-sulfonyl](2,2,2-trifluoroethyl)amino}phenyl)prop-2-enoate (3 entities in total) |
Functional Keywords | er-alpha, ligand complex, dmeri, transcription-transcription inhibitor complex, transcription/transcription inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 119928.44 |
Authors | Min, J.,Nwachukwu, J.C.,Min, C.K.,Njeri, J.W.,Srinivasan, S.,Rangarajan, E.S.,Nettles, C.C.,Yan, S.,Houtman, R.,Griffin, P.R.,Izard, T.,Katzenellenbogen, B.S.,Katzenellenbogen, J.A.,Nettles, K.W. (deposition date: 2021-08-10, release date: 2021-09-08, Last modification date: 2023-10-18) |
Primary citation | Min, J.,Nwachukwu, J.C.,Min, C.K.,Njeri, J.W.,Srinivasan, S.,Rangarajan, E.S.,Nettles, C.C.,Sanabria Guillen, V.,Ziegler, Y.,Yan, S.,Carlson, K.E.,Hou, Y.,Kim, S.H.,Novick, S.,Pascal, B.D.,Houtman, R.,Griffin, P.R.,Izard, T.,Katzenellenbogen, B.S.,Katzenellenbogen, J.A.,Nettles, K.W. Dual-mechanism estrogen receptor inhibitors. Proc.Natl.Acad.Sci.USA, 118:-, 2021 Cited by PubMed: 34452998DOI: 10.1073/pnas.2101657118 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.59 Å) |
Structure validation
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