Human metavinculin MVt R975W cardiomyopathy-associated mutant (residues 959-1134)

Summary for 5L0I

DescriptorVinculin, GLYCEROL, SODIUM ION, ... (4 entities in total)
Functional Keywords5-helix bundle, cytoskeletal protein, cell adhesion, cardiomyopathy
Biological sourceHomo sapiens (Human)
Cellular locationCell membrane ; Peripheral membrane protein ; Cytoplasmic side  P18206
Total number of polymer chains1
Total molecular weight19763.8
Chinthalapudi, K.,Izard, T. (deposition date: 2016-07-27, release date: 2016-08-31, Last modification date: 2017-08-23)
Primary citation
Chinthalapudi, K.,Rangarajan, E.S.,Brown, D.T.,Izard, T.
Differential lipid binding of vinculin isoforms promotes quasi-equivalent dimerization.
Proc.Natl.Acad.Sci.USA, 113:9539-9544, 2016
PubMed: 27503891 (PDB entries with the same primary citation)
DOI: 10.1073/pnas.1600702113
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.26925008.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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