5L0I
Human metavinculin MVt R975W cardiomyopathy-associated mutant (residues 959-1134)
Summary for 5L0I
Entry DOI | 10.2210/pdb5l0i/pdb |
Descriptor | Vinculin, GLYCEROL, SODIUM ION, ... (4 entities in total) |
Functional Keywords | 5-helix bundle, cytoskeletal protein, cell adhesion, cardiomyopathy |
Biological source | Homo sapiens (Human) |
Cellular location | Cell membrane ; Peripheral membrane protein ; Cytoplasmic side : P18206 |
Total number of polymer chains | 1 |
Total formula weight | 19763.80 |
Authors | Chinthalapudi, K.,Izard, T. (deposition date: 2016-07-27, release date: 2016-08-31, Last modification date: 2023-10-04) |
Primary citation | Chinthalapudi, K.,Rangarajan, E.S.,Brown, D.T.,Izard, T. Differential lipid binding of vinculin isoforms promotes quasi-equivalent dimerization. Proc.Natl.Acad.Sci.USA, 113:9539-9544, 2016 Cited by PubMed: 27503891DOI: 10.1073/pnas.1600702113 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.45 Å) |
Structure validation
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