5L0G

Human metavinculin MVt Q971R, R975D, T978R mutant (residues 959-1134) in complex with PIP2

Summary for 5L0G

DescriptorVinculin, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (3 entities in total)
Functional Keywords5-helix bundle, cytoskelatal protein, phospholipids, cell adhesion, structural protein
Biological sourceHomo sapiens (Human)
Cellular locationCell membrane ; Peripheral membrane protein ; Cytoplasmic side  P18206
Total number of polymer chains4
Total molecular weight80144.12
Authors
Chinthalapudi, K.,Izard, T. (deposition date: 2016-07-27, release date: 2016-08-31, Last modification date: 2017-11-01)
Primary citation
Chinthalapudi, K.,Rangarajan, E.S.,Brown, D.T.,Izard, T.
Differential lipid binding of vinculin isoforms promotes quasi-equivalent dimerization.
Proc.Natl.Acad.Sci.USA, 113:9539-9544, 2016
PubMed: 27503891 (PDB entries with the same primary citation)
DOI: 10.1073/pnas.1600702113
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3.4 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.2223400.2%2.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 5l0g
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Molmil generated image of 5l0g
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Molmil generated image of 5l0g
rotated about y axis by 90°

More Biological unit images

Molmil generated image of 5l0g
no rotation
Molmil generated image of 5l0g
rotated about x axis by 90°
Molmil generated image of 5l0g
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (5l0g.pdb1.gz [56.93 KB])
Coordinate files for Biological unit (5l0g.pdb2.gz [57.27 KB])
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