2Z3H
| Crystal structure of blasticidin S deaminase (BSD) complexed with deaminohydroxy blasticidin S | 分子名称: | 1-(4-{[(3R)-3-AMINO-5-{[(Z)-AMINO(IMINO)METHYL](METHYL)AMINO}PENTANOYL]AMINO}-2,3,4-TRIDEOXY-D-ERYTHRO-HEX-2-ENOPYRANURONOSYL)-4-HYDROXYPYRIMIDIN-2(1H)-ONE, Blasticidin-S deaminase, ZINC ION | 著者 | Kumasaka, T, Yamamoto, M, Furuichi, M, Nakasako, M, Kimura, M, Yamaguchi, I, Ueki, T. | 登録日 | 2007-06-04 | 公開日 | 2007-10-23 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Crystal structures of blasticidin S deaminase (BSD): implications for dynamic properties of catalytic zinc J.Biol.Chem., 282, 2007
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6EUE
| Rivastigmine analogue bound to Tc ACHE. | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Acetylcholinesterase, PENTAETHYLENE GLYCOL | 著者 | De la Mora, E, Brazzolotto, X, Dighe, S.N, Silman, I, Weik, M, Ross, B. | 登録日 | 2017-10-30 | 公開日 | 2018-11-14 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Rivastigmine and metabolite analogues with putative Alzheimer's disease-modifying properties in a Caenorhabditis elegans model Commun Chem, 2019
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6LXC
| X-ray structure of human PPARalpha ligand binding domain-saroglitazar co-crystals obtained by delipidation and cross-seeding | 分子名称: | (2S)-2-ethoxy-3-[4-[2-[2-methyl-5-(4-methylsulfanylphenyl)pyrrol-1-yl]ethoxy]phenyl]propanoic acid, Peroxisome proliferator-activated receptor alpha | 著者 | Kamata, S, Honda, A, Ishikawa, R, Akahane, M, Oyama, T, Ishii, I. | 登録日 | 2020-02-10 | 公開日 | 2020-11-11 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | 主引用文献 | PPAR alpha Ligand-Binding Domain Structures with Endogenous Fatty Acids and Fibrates. Iscience, 23, 2020
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2XZA
| Crystal Structure of recombinant A.17 antibody FAB fragment | 分子名称: | FAB A.17 HEAVY CHAIN, FAB A.17 LIGHT CHAIN | 著者 | Carletti, E, Nachon, F, Nicolet, Y, Masson, P, Kurkova, I, Smirnov, I, Friboulet, A, Tramontano, A, Gabibov, A. | 登録日 | 2010-11-24 | 公開日 | 2011-09-21 | 最終更新日 | 2020-03-11 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Reactibodies Generated by Kinetic Selection Couple Chemical Reactivity with Favorable Protein Dynamics. Proc.Natl.Acad.Sci.USA, 108, 2011
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5T6L
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8BG9
| Murine amyloid-beta filaments with the Arctic mutation (E22G) from APP(NL-G-F) mouse brains | ABeta | 分子名称: | Amyloid-beta protein 40 | 著者 | Yang, Y, Zhang, W.J, Murzin, A.G, Schweighauser, M, Huang, M, Lovestam, S.K.A, Peak-Chew, S.Y, Macdonald, J, Lavenir, I, Ghetti, B, Graff, C, Kumar, A, Nordber, A, Goedert, M, Scheres, S.H.W. | 登録日 | 2022-10-27 | 公開日 | 2023-01-18 | 最終更新日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Cryo-EM structures of amyloid-beta filaments with the Arctic mutation (E22G) from human and mouse brains. Acta Neuropathol, 145, 2023
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5N6A
| Cardiac muscle myosin motor domain in the pre-powerstroke state | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ... | 著者 | Planelles-Herrero, V.J, Hartman, J.J, Robert-Paganin, J, Malik, F.I, Houdusse, A. | 登録日 | 2017-02-14 | 公開日 | 2017-08-09 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Mechanistic and structural basis for activation of cardiac myosin force production by omecamtiv mecarbil. Nat Commun, 8, 2017
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1KZC
| Complex of MBP-C and high-affinity linear trimannose | 分子名称: | CALCIUM ION, CHLORIDE ION, MANNOSE-BINDING PROTEIN C, ... | 著者 | Ng, K.K, Kolatkar, A.R, Park-Snyder, S, Feinberg, H, Clark, D.A, Drickamer, K, Weis, W.I. | 登録日 | 2002-02-06 | 公開日 | 2002-07-05 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Orientation of bound ligands in mannose-binding proteins. Implications for multivalent ligand recognition. J.Biol.Chem., 277, 2002
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2XZC
| Crystal Structure of phosphonate-modified recombinant A.17 antibody FAB fragment | 分子名称: | 8-METHYL-8-AZABICYCLO[3.2.1]OCTAN-3-YL PHENYLPHOSPHONATE, CHLORIDE ION, FAB A.17 HEAVY CHAIN, ... | 著者 | Carletti, E, Nachon, F, Nicolet, Y, Masson, P, Kurkova, I, Smirnov, I, Friboulet, A, Tramontano, A, Gabibov, A. | 登録日 | 2010-11-24 | 公開日 | 2011-09-21 | 最終更新日 | 2020-03-11 | 実験手法 | X-RAY DIFFRACTION (1.36 Å) | 主引用文献 | Reactibodies Generated by Kinetic Selection Couple Chemical Reactivity with Favorable Protein Dynamics. Proc.Natl.Acad.Sci.USA, 108, 2011
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6BD8
| Crystal structure of human CYP3A4 bound to an inhibitor | 分子名称: | Cytochrome P450 3A4, PROTOPORPHYRIN IX CONTAINING FE, S-{(2S)-2-[(1-tert-butoxyethenyl)amino]-3-phenylpropyl}-N~2~-cyclopentyl-N-[(pyridin-3-yl)methyl]-L-cysteinamide | 著者 | Sevrioukova, I. | 登録日 | 2017-10-21 | 公開日 | 2017-12-13 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.38 Å) | 主引用文献 | Interaction of the rationally designed ritonavir-like inhibitors with human cytochrome P450 3A4: Impact of the side group interplay Mol. Pharm., 2017
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4YPL
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8BG0
| Amyloid-beta tetrameric filaments with the Arctic mutation (E22G) from Alzheimer's disease brains | ABeta40 | 分子名称: | Amyloid-beta precursor protein | 著者 | Yang, Y, Zhang, W.J, Murzin, A.G, Schweighauser, M, Huang, M, Lovestam, S.K.A, Peak-Chew, S.Y, Macdonald, J, Lavenir, I, Ghetti, B, Graff, C, Kumar, A, Nordber, A, Goedert, M, Scheres, S.H.W. | 登録日 | 2022-10-27 | 公開日 | 2023-01-18 | 最終更新日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (1.99 Å) | 主引用文献 | Cryo-EM structures of amyloid-beta filaments with the Arctic mutation (E22G) from human and mouse brains. Acta Neuropathol, 145, 2023
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4PAN
| A conserved phenylalanine as relay between the 5 helix and the GDP binding region of heterotrimeric G protein | 分子名称: | CHLORIDE ION, GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | 著者 | Kaya, A.I, Lokits, A.D, Gilbert, J, Iverson, T.M, Meiler, J, Hamm, H.E. | 登録日 | 2014-04-09 | 公開日 | 2014-07-30 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | A Conserved Phenylalanine as a Relay between the alpha 5 Helix and the GDP Binding Region of Heterotrimeric Gi Protein alpha Subunit. J.Biol.Chem., 289, 2014
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6BDK
| Crystal structure of human CYP3A4 bound to an inhibitor | 分子名称: | Cytochrome P450 3A4, PROTOPORPHYRIN IX CONTAINING FE, tert-butyl [(2S)-1-{[(2R)-2-(cyclopentylamino)-3-oxo-3-{[(pyridin-3-yl)methyl]amino}propyl]sulfanyl}-3-(1H-indol-3-yl)propan-2-yl]carbamate | 著者 | Sevrioukova, I. | 登録日 | 2017-10-23 | 公開日 | 2017-12-13 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.67 Å) | 主引用文献 | Inhibition of Human CYP3A4 by Rationally Designed Ritonavir-Like Compounds: Impact and Interplay of the Side Group Functionalities. Mol Pharm., 15, 2018
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3FNM
| Crystal structure of acivicin-inhibited gamma-glutamyltranspeptidase reveals critical roles for its C-terminus in autoprocessing and catalysis | 分子名称: | (2S)-AMINO[(5S)-3-CHLORO-4,5-DIHYDROISOXAZOL-5-YL]ACETIC ACID, Gamma-glutamyltranspeptidase (Ggt) Large subunit, Gamma-glutamyltranspeptidase (Ggt) Small subunit | 著者 | Williams, K, Cullati, S, Sand, A, Biterova, E.I, Barycki, J.J. | 登録日 | 2008-12-25 | 公開日 | 2009-05-19 | 最終更新日 | 2017-11-01 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Crystal Structure of Acivicin-Inhibited gamma-Glutamyltranspeptidase Reveals Critical Roles for Its C-Terminus in Autoprocessing and Catalysis. Biochemistry, 48, 2009
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6SBQ
| The crystal structure of PfA-M1 in complex with 7-amino-4-phenyl-5,7,8,9-tetrahydrobenzocyclohepten-6-one | 分子名称: | DI(HYDROXYETHYL)ETHER, M1-family alanyl aminopeptidase, MALONATE ION, ... | 著者 | Salomon, E, Schmitt, M, Mouray, E, McEwen, A.G, Torchy, M, Poussin-Courmontagne, P, Alavi, S, Tarnus, C, Cavarelli, J, Florent, I, Albrecht, S. | 登録日 | 2019-07-22 | 公開日 | 2020-03-25 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.33 Å) | 主引用文献 | Aminobenzosuberone derivatives as PfA-M1 inhibitors: Molecular recognition and antiplasmodial evaluation. Bioorg.Chem., 98, 2020
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8BFZ
| Amyloid-beta 42 filaments extracted from the human brain with Arctic mutation (E22G) of Alzheimer's disease | ABeta42 | 分子名称: | Amyloid-beta precursor protein | 著者 | Yang, Y, Zhang, W.J, Murzin, A.G, Schweighauser, M, Huang, M, Lovestam, S.K.A, Peak-Chew, S.Y, Macdonald, J, Lavenir, I, Ghetti, B, Graff, C, Kumar, A, Nordberg, A, Goedert, M, Scheres, S.H.W. | 登録日 | 2022-10-27 | 公開日 | 2023-01-18 | 最終更新日 | 2024-01-31 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Cryo-EM structures of amyloid-beta filaments with the Arctic mutation (E22G) from human and mouse brains. Acta Neuropathol, 145, 2023
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6MEJ
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5TE8
| Crystal structure of the midazolam-bound human CYP3A4 | 分子名称: | 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine, Cytochrome P450 3A4, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Sevrioukova, I, Poulos, T. | 登録日 | 2016-09-20 | 公開日 | 2016-12-07 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structural basis for regiospecific midazolam oxidation by human cytochrome P450 3A4. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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6SF5
| Mn-containing form of the ribonucleotide reductase NrdB protein from Leeuwenhoekiella blandensis | 分子名称: | MANGANESE (II) ION, Ribonucleoside-diphosphate reductase, beta subunit 1 | 著者 | Hasan, M, Rozman Grinberg, I, Sjoberg, B.M, Logan, D.T. | 登録日 | 2019-08-01 | 公開日 | 2019-08-28 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Class Id ribonucleotide reductase utilizes a Mn2(IV,III) cofactor and undergoes large conformational changes on metal loading. J.Biol.Inorg.Chem., 24, 2019
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1KZB
| Complex of MBP-C and trimannosyl core | 分子名称: | CALCIUM ION, MANNOSE-BINDING PROTEIN C, alpha-D-mannopyranose | 著者 | Ng, K.K, Kolatkar, A.R, Park-Snyder, S, Feinberg, H, Clark, D.A, Drickamer, K, Weis, W.I. | 登録日 | 2002-02-06 | 公開日 | 2002-07-05 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Orientation of bound ligands in mannose-binding proteins. Implications for multivalent ligand recognition. J.Biol.Chem., 277, 2002
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6MAK
| HBO1 is required for the maintenance of leukaemia stem cells | 分子名称: | ACETYL COENZYME *A, BRD1 protein, Histone acetyltransferase KAT7, ... | 著者 | Ren, B, Peat, T.S, Monahan, B, Dawson, M, Street, I. | 登録日 | 2018-08-27 | 公開日 | 2019-12-25 | 最終更新日 | 2020-01-22 | 実験手法 | X-RAY DIFFRACTION (2.13 Å) | 主引用文献 | HBO1 is required for the maintenance of leukaemia stem cells. Nature, 577, 2020
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1Q5Q
| The Rhodococcus 20S proteasome | 分子名称: | proteasome alpha-type subunit 1, proteasome beta-type subunit 1 | 著者 | Kwon, Y.D, Nagy, I, Adams, P.D, Baumeister, W, Jap, B.K. | 登録日 | 2003-08-08 | 公開日 | 2003-12-16 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Crystal structures of the Rhodococcus proteasome with and without its pro-peptides: implications for the role of the pro-peptide in proteasome assembly. J.Mol.Biol., 335, 2004
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6SF4
| Apo form of the ribonucleotide reductase NrdB protein from Leeuwenhoekiella blandensis | 分子名称: | Ribonucleoside-diphosphate reductase, beta subunit 1 | 著者 | Hasan, M, Rozman Grinberg, I, Sjoberg, B.M, Logan, D.T. | 登録日 | 2019-07-31 | 公開日 | 2019-08-28 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Class Id ribonucleotide reductase utilizes a Mn2(IV,III) cofactor and undergoes large conformational changes on metal loading. J.Biol.Inorg.Chem., 24, 2019
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6FII
| Tubulin-Spongistatin complex | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, DIMETHYL SULFOXIDE, ... | 著者 | Menchon, G, Prota, A.E, Lucena Angell, D, Bucher, P, Mueller, R, Paterson, I, Diaz, J.F, Altmann, K.-H, Steinmetz, M.O. | 登録日 | 2018-01-18 | 公開日 | 2018-05-30 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.405 Å) | 主引用文献 | A fluorescence anisotropy assay to discover and characterize ligands targeting the maytansine site of tubulin. Nat Commun, 9, 2018
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