Loading
PDBj
English日本語简体中文繁體中文한국어
✖
ﾒﾆｭｰPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
PDB: 54 件
3KCG
DownloadVisualize
BU of 3kcg by Molmil
Crystal structure of the antithrombin-factor IXa-pentasaccharide complex
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 3,4-di-O-methyl-2,6-di-O-sulfo-alpha-D-glucopyranose-(1-4)-2,3-di-O-methyl-beta-D-glucopyranuronic acid-(1-4)-2,3,6-tri-O-sulfo-alpha-D-glucopyranose-(1-4)-3-O-methyl-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-methyl 2,3,6-tri-O-sulfo-alpha-D-glucopyranoside, Antithrombin-III, ...
著者Huntington, J.A, Johnson, D.J.D.
登録日2009-10-21
公開日2010-02-02
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Molecular basis of factor IXa recognition by heparin-activated antithrombin revealed by a 1.7-A structure of the ternary complex.
Proc.Natl.Acad.Sci.USA, 107, 2010
1QMB
DownloadVisualize
BU of 1qmb by Molmil
Cleaved alpha-1-antitrypsin polymer
分子名称: ALPHA-1-ANTITRYPSIN
著者Huntington, J.A, Pannu, N.S, Hazes, B, Read, R.J, Lomas, D.A, Carrell, R.W.
登録日1999-09-24
公開日2000-02-06
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献A 2.6A Structure of a Serpin Polymer and Implications for Conformational Disease
J.Mol.Biol., 293, 1999
6RFK
DownloadVisualize
BU of 6rfk by Molmil
Crystal structure of EGRCK-inhibited Gla-domainless fIXa (K148Q, R150Q variant)
分子名称: 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, Coagulation factor IX, ...
著者Huntington, J.A, Sendall, T.J.
登録日2019-04-15
公開日2019-06-12
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献NMR resonance assignments of apo and EGRCK-inhibited factor IXa
To Be Published
3T1P
DownloadVisualize
BU of 3t1p by Molmil
Crystal structure of an alpha-1-antitrypsin trimer
分子名称: Alpha-1-antitrypsin
著者Huntington, J.A, Yamasaki, M.
登録日2011-07-22
公開日2011-08-17
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (3.9 Å)
主引用文献Molecular basis of alpha 1-antitrypsin deficiency revealed by the structure of a domain-swapped trimer.
EMBO Rep., 12, 2011
3NDF
DownloadVisualize
BU of 3ndf by Molmil
Cleaved antitrypsin with P8-P6 Asp
分子名称: Alpha-1-antitrypsin
著者Huntington, J.A, Sendall, T.J, Yamasaki, M.
登録日2010-06-07
公開日2010-07-28
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Loop-sheet mechanism of serpin polymerization tested by reactive center loop mutations
J. Biol. Chem., 285, 2010
3EVJ
DownloadVisualize
BU of 3evj by Molmil
Intermediate structure of antithrombin bound to the natural pentasaccharide
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-4)-2-deoxy-3,6-di-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-methyl 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranoside, ...
著者Huntington, J.A, Belzar, K.J.
登録日2008-10-13
公開日2008-10-21
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献The critical role of hinge-region expulsion in the induced-fit heparin binding mechanism of antithrombin.
J. Mol. Biol., 386, 2009
1NQ9
DownloadVisualize
BU of 1nq9 by Molmil
Crystal Structure of Antithrombin in the Pentasaccharide-Bound Intermediate State
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3,4-di-O-methyl-2,6-di-O-sulfo-alpha-D-glucopyranose-(1-4)-2,3-di-O-methyl-beta-D-glucopyranuronic acid-(1-4)-2,3,6-tri-O-sulfo-alpha-D-glucopyranose-(1-4)-3-O-methyl-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-methyl 2,3,6-tri-O-sulfo-alpha-D-glucopyranoside, ...
著者Huntington, J.A, Johnson, D.J.D.
登録日2003-01-21
公開日2003-09-30
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Crystal Structure of Antithrombin in a Heparin-Bound Intermediate State
Biochemistry, 42, 2003
5NBV
DownloadVisualize
BU of 5nbv by Molmil
Crystal structure of native alpha-1-antitrypsin with seven stabilising mutations
分子名称: Alpha-1-antitrypsin, GLYCEROL
著者Huntington, J.A, Pomowski, A, Johnson, D.J.D.
登録日2017-03-02
公開日2018-03-21
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.73 Å)
主引用文献CRYSTAL STRUCTURE OF THE Z VARIANT OF ALPHA-1-ANTITRYPSIN REVEALS STRUCTURAL AND DYNAMICAL CHANGES AND SUPPORTS A C-TERMINAL DOMAIN SWAP MECHANISM OF POLYMERIZATION
To Be Published
5NBU
DownloadVisualize
BU of 5nbu by Molmil
Crystal structure of native alpha-1-antitrypsin with seven stabilising mutations
分子名称: Alpha-1-antitrypsin, GLYCEROL, OXAMIC ACID
著者Huntington, J.A, Pomowski, A, Johnson, D.J.D.
登録日2017-03-02
公開日2018-03-21
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.67 Å)
主引用文献CRYSTAL STRUCTURE OF THE Z VARIANT OF ALPHA-1-ANTITRYPSIN REVEALS STRUCTURAL AND DYNAMICAL CHANGES AND SUPPORTS A C-TERMINAL DOMAIN SWAP MECHANISM OF POLYMERIZATION
To Be Published
1EZX
DownloadVisualize
BU of 1ezx by Molmil
CRYSTAL STRUCTURE OF A SERPIN:PROTEASE COMPLEX
分子名称: ALPHA-1-ANTITRYPSIN, TRYPSIN
著者Huntington, J.A, Carrell, R.W.
登録日2000-05-12
公開日2000-10-25
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structure of a serpin-protease complex shows inhibition by deformation.
Nature, 407, 2000
4DY7
DownloadVisualize
BU of 4dy7 by Molmil
Crystal structures of protease nexin-1 in complex with S195A thrombin
分子名称: ACETATE ION, CALCIUM ION, Glia-derived nexin, ...
著者Huntington, J.A, Li, W.
登録日2012-02-28
公開日2012-08-15
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal structures of protease nexin-1 in complex with heparin and thrombin suggest a 2-step recognition mechanism.
Blood, 120, 2012
4DY0
DownloadVisualize
BU of 4dy0 by Molmil
Crystal structure of native protease nexin-1 with heparin
分子名称: 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid, GLYCEROL, Glia-derived nexin, ...
著者Huntington, J.A, Li, W.
登録日2012-02-28
公開日2012-08-15
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Crystal structures of protease nexin-1 in complex with heparin and thrombin suggest a 2-step recognition mechanism.
Blood, 120, 2012
1JOU
DownloadVisualize
BU of 1jou by Molmil
Crystal Structure of Native S195A Thrombin with an Unoccupied Active Site
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETIC ACID, GLYCEROL, ...
著者Huntington, J.A, Esmon, C.T.
登録日2001-07-31
公開日2001-08-10
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献The molecular basis of thrombin allostery revealed by a 1.8A structure of the slow form
Structure, 11, 2003
1LQ8
DownloadVisualize
BU of 1lq8 by Molmil
Crystal structure of cleaved protein C inhibitor
分子名称: 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Huntington, J.A, Kjellberg, M, Stenflo, J.
登録日2002-05-09
公開日2003-02-11
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Crystal Structure of Protein C Inhibitor Provides Insights into Hormone Binding and Heparin Activation
Structure, 11, 2003
2AFQ
DownloadVisualize
BU of 2afq by Molmil
1.9 angstrom crystal structure of wild-type human thrombin in the sodium free state
分子名称: GLYCEROL, Prothrombin
著者Johnson, D.J.D, Adams, T.E, Huntington, J.A.
登録日2005-07-26
公開日2005-11-15
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (1.93 Å)
主引用文献Crystal structure of wild-type human thrombin in the Na+-free state
Biochem.J., 392, 2005
1JB2
DownloadVisualize
BU of 1jb2 by Molmil
CRYSTAL STRUCTURE OF NTF2 M84E MUTANT
分子名称: NUCLEAR TRANSPORT FACTOR 2
著者Chaillan-Huntington, C, Butler, P.J, Huntington, J.A, Akin, D, Feldherr, C, Stewart, M.
登録日2001-06-01
公開日2002-03-13
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献NTF2 monomer-dimer equilibrium.
J.Mol.Biol., 314, 2001
1JB5
DownloadVisualize
BU of 1jb5 by Molmil
CRYSTAL STRUCTURE OF NTF2 M118E MUTANT
分子名称: NUCLEAR TRANSPORT FACTOR 2
著者Chaillan-Huntington, C, Butler, P.J, Huntington, J.A, Akin, D, Feldherr, C, Stewart, M.
登録日2001-06-01
公開日2002-03-13
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献NTF2 monomer-dimer equilibrium.
J.Mol.Biol., 314, 2001
1JB4
DownloadVisualize
BU of 1jb4 by Molmil
CRYSTAL STRUCTURE OF NTF2 M102E MUTANT
分子名称: NUCLEAR TRANSPORT FACTOR 2
著者Chaillan-Huntington, C, Butler, P.J, Huntington, J.A, Akin, D, Feldherr, C, Stewart, M.
登録日2001-06-01
公開日2002-03-13
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.23 Å)
主引用文献NTF2 monomer-dimer equilibrium.
J.Mol.Biol., 314, 2001
7PMU
DownloadVisualize
BU of 7pmu by Molmil
Crystal structure of native Iripin-8
分子名称: DI(HYDROXYETHYL)ETHER, HEXAETHYLENE GLYCOL, Serpin-8, ...
著者Polderdijk, S, Kotal, J, Chmelar, J, Huntington, J.A.
登録日2021-09-02
公開日2021-10-13
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.89 Å)
主引用文献Ixodes ricinus Salivary Serpin Iripin-8 Inhibits the Intrinsic Pathway of Coagulation and Complement.
Int J Mol Sci, 22, 2021
2ZNH
DownloadVisualize
BU of 2znh by Molmil
Crystal Structure of a Domain-Swapped Serpin Dimer
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Antithrombin-III, ...
著者Yamasaki, M, Huntington, J.A.
登録日2008-04-25
公開日2008-10-21
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal structure of a stable dimer reveals the molecular basis of serpin polymerization
Nature, 455, 2008
2OL2
DownloadVisualize
BU of 2ol2 by Molmil
High Resolution Structure of Native PCI in Space Group P21
分子名称: GLYCEROL, Plasma serine protease inhibitor
著者Li, W, Huntington, J.A.
登録日2007-01-18
公開日2007-03-13
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structure of native protein C inhibitor provides insight into its multiple functions.
J.Biol.Chem., 282, 2007
5E8E
DownloadVisualize
BU of 5e8e by Molmil
Crystal structure of thrombin bound to an exosite 1-specific IgA Fab
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CITRIC ACID, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, ...
著者Baglin, T.P, Langdown, J, Frasson, R, Huntington, J.A.
登録日2015-10-14
公開日2015-10-28
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Discovery and characterization of an antibody directed against exosite I of thrombin.
J.Thromb.Haemost., 14, 2016
2BEH
DownloadVisualize
BU of 2beh by Molmil
Crystal structure of antithrombin variant S137A/V317C/T401C with plasma latent antithrombin
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Antithrombin-III, ...
著者Johnson, D.J, Luis, S.A, Huntington, J.A.
登録日2005-10-24
公開日2005-11-01
最終更新日2021-10-20
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Crystal structure of monomeric native antithrombin reveals a novel reactive center loop conformation.
J.Biol.Chem., 281, 2006
2B4X
DownloadVisualize
BU of 2b4x by Molmil
Crystal Structure of Antithrombin-III
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Antithrombin-III
著者Adams, T.E, Huntington, J.A, Johnson, D.J.D, Bock, S.C.
登録日2005-09-27
公開日2006-10-10
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal Structure of Antithrombin-III
To be Published
2B5T
DownloadVisualize
BU of 2b5t by Molmil
2.1 Angstrom structure of a nonproductive complex between antithrombin, synthetic heparin mimetic SR123781 and two S195A thrombin molecules
分子名称: 2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose-(1-4)-2,3,6-tri-O-sulfo-alpha-D-glucopyranose-(1-4)-2,3,6-tri-O-sulfonato-beta-D-glucopyranose-(1-4)-2,3-di-O-methyl-6-O-sulfonato-alpha-D-glucopyranose-(1-4)-2,3,6-tri-O-methyl-beta-D-glucopyranose-(1-4)-2,3,6-tri-O-methyl-alpha-D-glucopyranose-(1-4)-2,3,6-tri-O-methyl-beta-D-glucopyranose-(1-4)-2,3,6-tri-O-methyl-alpha-D-glucopyranose-(1-4)-2,3,6-tri-O-methyl-beta-D-glucopyranose-(1-4)-2,3,6-tri-O-methyl-alpha-D-glucopyranose-(1-4)-2,3,6-tri-O-methyl-beta-D-glucopyranose-(1-4)-2,3-di-O-methyl-6-O-sulfonato-alpha-D-glucopyranose-(1-4)-2,3-di-O-methyl-beta-D-glucopyranuronic acid-(1-4)-2,3,6-tri-O-sulfo-alpha-D-glucopyranose-(1-4)-2,3-di-O-methyl-alpha-L-idopyranuronic acid-(1-4)-methyl 3-O-methyl-2,6-di-O-sulfo-alpha-D-glucopyranoside, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Johnson, D.J, Li, W, Luis, S.A, Carrell, R.W, Huntington, J.A.
登録日2005-09-29
公開日2006-09-19
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal structure of monomeric native antithrombin reveals a novel reactive center loop conformation.
J.Biol.Chem., 281, 2006

 

123>

226707

件を2024-10-30に公開中

PDB statisticsPDBj update infoContact PDBjnumon