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PDB: 63 results
1LQ8
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BU of 1lq8 by Molmil
Crystal structure of cleaved protein C inhibitor
Descriptor: 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Huntington, J.A, Kjellberg, M, Stenflo, J.
Deposit date:2002-05-09
Release date:2003-02-11
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structure of Protein C Inhibitor Provides Insights into Hormone Binding and Heparin Activation
Structure, 11, 2003
5NBV
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BU of 5nbv by Molmil
Crystal structure of native alpha-1-antitrypsin with seven stabilising mutations
Descriptor: Alpha-1-antitrypsin, GLYCEROL
Authors:Huntington, J.A, Pomowski, A, Johnson, D.J.D.
Deposit date:2017-03-02
Release date:2018-03-21
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:CRYSTAL STRUCTURE OF THE Z VARIANT OF ALPHA-1-ANTITRYPSIN REVEALS STRUCTURAL AND DYNAMICAL CHANGES AND SUPPORTS A C-TERMINAL DOMAIN SWAP MECHANISM OF POLYMERIZATION
To Be Published
6RFK
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BU of 6rfk by Molmil
Crystal structure of EGRCK-inhibited Gla-domainless fIXa (K148Q, R150Q variant)
Descriptor: 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, Coagulation factor IX, ...
Authors:Huntington, J.A, Sendall, T.J.
Deposit date:2019-04-15
Release date:2019-06-12
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:NMR resonance assignments of apo and EGRCK-inhibited factor IXa
To Be Published
1QMB
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BU of 1qmb by Molmil
Cleaved alpha-1-antitrypsin polymer
Descriptor: ALPHA-1-ANTITRYPSIN
Authors:Huntington, J.A, Pannu, N.S, Hazes, B, Read, R.J, Lomas, D.A, Carrell, R.W.
Deposit date:1999-09-24
Release date:2000-02-06
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:A 2.6A Structure of a Serpin Polymer and Implications for Conformational Disease
J.Mol.Biol., 293, 1999
3NDF
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BU of 3ndf by Molmil
Cleaved antitrypsin with P8-P6 Asp
Descriptor: Alpha-1-antitrypsin
Authors:Huntington, J.A, Sendall, T.J, Yamasaki, M.
Deposit date:2010-06-07
Release date:2010-07-28
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Loop-sheet mechanism of serpin polymerization tested by reactive center loop mutations
J. Biol. Chem., 285, 2010
1JOU
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BU of 1jou by Molmil
Crystal Structure of Native S195A Thrombin with an Unoccupied Active Site
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETIC ACID, GLYCEROL, ...
Authors:Huntington, J.A, Esmon, C.T.
Deposit date:2001-07-31
Release date:2001-08-10
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The molecular basis of thrombin allostery revealed by a 1.8A structure of the slow form
Structure, 11, 2003
3T1P
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BU of 3t1p by Molmil
Crystal structure of an alpha-1-antitrypsin trimer
Descriptor: Alpha-1-antitrypsin
Authors:Huntington, J.A, Yamasaki, M.
Deposit date:2011-07-22
Release date:2011-08-17
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.9 Å)
Cite:Molecular basis of alpha 1-antitrypsin deficiency revealed by the structure of a domain-swapped trimer.
EMBO Rep., 12, 2011
5NBU
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BU of 5nbu by Molmil
Crystal structure of native alpha-1-antitrypsin with seven stabilising mutations
Descriptor: Alpha-1-antitrypsin, GLYCEROL, OXAMIC ACID
Authors:Huntington, J.A, Pomowski, A, Johnson, D.J.D.
Deposit date:2017-03-02
Release date:2018-03-21
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:CRYSTAL STRUCTURE OF THE Z VARIANT OF ALPHA-1-ANTITRYPSIN REVEALS STRUCTURAL AND DYNAMICAL CHANGES AND SUPPORTS A C-TERMINAL DOMAIN SWAP MECHANISM OF POLYMERIZATION
To Be Published
1NQ9
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BU of 1nq9 by Molmil
Crystal Structure of Antithrombin in the Pentasaccharide-Bound Intermediate State
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3,4-di-O-methyl-2,6-di-O-sulfo-alpha-D-glucopyranose-(1-4)-2,3-di-O-methyl-beta-D-glucopyranuronic acid-(1-4)-2,3,6-tri-O-sulfo-alpha-D-glucopyranose-(1-4)-3-O-methyl-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-methyl 2,3,6-tri-O-sulfo-alpha-D-glucopyranoside, ...
Authors:Huntington, J.A, Johnson, D.J.D.
Deposit date:2003-01-21
Release date:2003-09-30
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal Structure of Antithrombin in a Heparin-Bound Intermediate State
Biochemistry, 42, 2003
1EZX
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BU of 1ezx by Molmil
CRYSTAL STRUCTURE OF A SERPIN:PROTEASE COMPLEX
Descriptor: ALPHA-1-ANTITRYPSIN, TRYPSIN
Authors:Huntington, J.A, Carrell, R.W.
Deposit date:2000-05-12
Release date:2000-10-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of a serpin-protease complex shows inhibition by deformation.
Nature, 407, 2000
3EVJ
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BU of 3evj by Molmil
Intermediate structure of antithrombin bound to the natural pentasaccharide
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-4)-2-deoxy-3,6-di-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-methyl 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranoside, ...
Authors:Huntington, J.A, Belzar, K.J.
Deposit date:2008-10-13
Release date:2008-10-21
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3 Å)
Cite:The critical role of hinge-region expulsion in the induced-fit heparin binding mechanism of antithrombin.
J. Mol. Biol., 386, 2009
3KCG
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BU of 3kcg by Molmil
Crystal structure of the antithrombin-factor IXa-pentasaccharide complex
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 3,4-di-O-methyl-2,6-di-O-sulfo-alpha-D-glucopyranose-(1-4)-2,3-di-O-methyl-beta-D-glucopyranuronic acid-(1-4)-2,3,6-tri-O-sulfo-alpha-D-glucopyranose-(1-4)-3-O-methyl-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-methyl 2,3,6-tri-O-sulfo-alpha-D-glucopyranoside, Antithrombin-III, ...
Authors:Huntington, J.A, Johnson, D.J.D.
Deposit date:2009-10-21
Release date:2010-02-02
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Molecular basis of factor IXa recognition by heparin-activated antithrombin revealed by a 1.7-A structure of the ternary complex.
Proc.Natl.Acad.Sci.USA, 107, 2010
4DY0
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BU of 4dy0 by Molmil
Crystal structure of native protease nexin-1 with heparin
Descriptor: 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid, GLYCEROL, Glia-derived nexin, ...
Authors:Huntington, J.A, Li, W.
Deposit date:2012-02-28
Release date:2012-08-15
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Crystal structures of protease nexin-1 in complex with heparin and thrombin suggest a 2-step recognition mechanism.
Blood, 120, 2012
4DY7
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BU of 4dy7 by Molmil
Crystal structures of protease nexin-1 in complex with S195A thrombin
Descriptor: ACETATE ION, CALCIUM ION, Glia-derived nexin, ...
Authors:Huntington, J.A, Li, W.
Deposit date:2012-02-28
Release date:2012-08-15
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structures of protease nexin-1 in complex with heparin and thrombin suggest a 2-step recognition mechanism.
Blood, 120, 2012
1FSQ
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BU of 1fsq by Molmil
X-RAY CRYSTAL STRUCTURE OF COBALT-BOUND F93S/F95L/W97M CARBONIC ANHYDRASE (CAII) VARIANT
Descriptor: CARBONIC ANHYDRASE II, COBALT (II) ION
Authors:Cox, J.D, Hunt, J.A, Compher, K.M, Fierke, C.A, Christianson, D.W.
Deposit date:2000-09-11
Release date:2001-01-17
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural influence of hydrophobic core residues on metal binding and specificity in carbonic anhydrase II.
Biochemistry, 39, 2000
1FR4
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BU of 1fr4 by Molmil
X-RAY CRYSTAL STRUCTURE OF COPPER-BOUND F93I/F95M/W97V CARBONIC ANHYDRASE (CAII) VARIANT
Descriptor: CARBONIC ANHYDRASE II, COPPER (II) ION, SULFATE ION
Authors:Cox, J.D, Hunt, J.A, Compher, K.M, Fierke, C.A, Christianson, D.W.
Deposit date:2000-09-07
Release date:2001-01-17
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural influence of hydrophobic core residues on metal binding and specificity in carbonic anhydrase II.
Biochemistry, 39, 2000
1FSN
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BU of 1fsn by Molmil
X-RAY CRYSTAL STRUCTURE OF METAL-FREE F93S/F95L/W97M CARBONIC ANHYDRASE (CAII) VARIANT
Descriptor: CARBONIC ANHYDRASE II
Authors:Cox, J.D, Hunt, J.A, Compher, K.M, Fierke, C.A, Christianson, D.W.
Deposit date:2000-09-11
Release date:2001-01-17
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural influence of hydrophobic core residues on metal binding and specificity in carbonic anhydrase II.
Biochemistry, 39, 2000
1FQR
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BU of 1fqr by Molmil
X-RAY CRYSTAL STRUCTURE OF COBALT-BOUND F93I/F95M/W97V CARBONIC ANHYDRASE (CAII) VARIANT
Descriptor: CARBONIC ANHYDRASE, COBALT (II) ION
Authors:Cox, J.D, Hunt, J.A, Compher, K.M, Fierke, C.A, Christianson, D.W.
Deposit date:2000-09-06
Release date:2001-01-17
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural influence of hydrophobic core residues on metal binding and specificity in carbonic anhydrase II.
Biochemistry, 39, 2000
1FQN
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BU of 1fqn by Molmil
X-RAY CRYSTAL STRUCTURE OF METAL-FREE F93I/F95M/W97V CARBONIC ANHYDRASE (CAII) VARIANT
Descriptor: CARBONIC ANHYDRASE
Authors:Cox, J.D, Hunt, J.A, Compher, K.M, Fierke, C.A, Christianson, D.W.
Deposit date:2000-09-06
Release date:2001-01-17
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural influence of hydrophobic core residues on metal binding and specificity in carbonic anhydrase II.
Biochemistry, 39, 2000
1FR7
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BU of 1fr7 by Molmil
X-RAY CRYSTAL STRUCTURE OF ZINC-BOUND F93S/F95L/W97M CARBONIC ANHYDRASE (CAII) VARIANT
Descriptor: CARBONIC ANHYDRASE II, ZINC ION
Authors:Cox, J.D, Hunt, J.A, Compher, K.M, Fierke, C.A, Christianson, D.W.
Deposit date:2000-09-07
Release date:2001-01-17
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural influence of hydrophobic core residues on metal binding and specificity in carbonic anhydrase II.
Biochemistry, 39, 2000
1FSR
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BU of 1fsr by Molmil
X-RAY CRYSTAL STRUCTURE OF COPPER-BOUND F93S/F95L/W97M CARBONIC ANHYDRASE (CAII) VARIANT
Descriptor: CARBONIC ANHYDRASE II, COPPER (II) ION
Authors:Cox, J.D, Hunt, J.A, Compher, K.M, Fierke, C.A, Christianson, D.W.
Deposit date:2000-09-11
Release date:2001-01-17
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural influence of hydrophobic core residues on metal binding and specificity in carbonic anhydrase II.
Biochemistry, 39, 2000
1FQL
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BU of 1fql by Molmil
X-RAY CRYSTAL STRUCTURE OF ZINC-BOUND F95M/W97V CARBONIC ANHYDRASE (CAII) VARIANT
Descriptor: CARBONIC ANHYDRASE, MERCURY (II) ION, ZINC ION
Authors:Cox, J.D, Hunt, J.A, Compher, K.M, Fierke, C.A, Christianson, D.W.
Deposit date:2000-09-05
Release date:2001-01-17
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural influence of hydrophobic core residues on metal binding and specificity in carbonic anhydrase II.
Biochemistry, 39, 2000
1FQM
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BU of 1fqm by Molmil
X-RAY CRYSTAL STRUCTURE OF ZINC-BOUND F93I/F95M/W97V CARBONIC ANHYDRASE (CAII) VARIANT
Descriptor: CARBONIC ANHYDRASE, MERCURY (II) ION, ZINC ION
Authors:Cox, J.D, Hunt, J.A, Compher, K.M, Fierke, C.A, Christianson, D.W.
Deposit date:2000-09-06
Release date:2001-01-17
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural influence of hydrophobic core residues on metal binding and specificity in carbonic anhydrase II.
Biochemistry, 39, 2000
1LK6
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BU of 1lk6 by Molmil
Structure of dimeric antithrombin complexed with a P14-P9 reactive loop peptide and an exogenous tripeptide
Descriptor: 2-acetamido-2-deoxy-alpha-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ...
Authors:Zhou, A, Huntington, J.A, Lomas, D.A, Carrell, R.W, Stein, P.E.
Deposit date:2002-04-24
Release date:2003-06-03
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Serpin Polymerization Is Prevented by a Hydrogen Bond Network That Is Centered on His-334 and Stabilized by Glycerol
J.Biol.Chem., 278, 2003
1JB5
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BU of 1jb5 by Molmil
CRYSTAL STRUCTURE OF NTF2 M118E MUTANT
Descriptor: NUCLEAR TRANSPORT FACTOR 2
Authors:Chaillan-Huntington, C, Butler, P.J, Huntington, J.A, Akin, D, Feldherr, C, Stewart, M.
Deposit date:2001-06-01
Release date:2002-03-13
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:NTF2 monomer-dimer equilibrium.
J.Mol.Biol., 314, 2001

 

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