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PDB: 735 results

1M74
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BU of 1m74 by Molmil
Crystal structure of Mg-ADP-bound SecA from Bacillus subtilis
Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Preprotein translocase secA, ...
Authors:Hunt, J.F, Weinkauf, S, Henry, L, Fak, J.J, McNicholas, P, Oliver, D.B, Deisenhofer, J.
Deposit date:2002-07-16
Release date:2002-09-20
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3 Å)
Cite:Nucleotide Control of Interdomain Interactions in the Conformational Reaction Cycle of SecA
Science, 297, 2002
1M6N
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BU of 1m6n by Molmil
Crystal structure of the SecA translocation ATPase from Bacillus subtilis
Descriptor: Preprotein translocase secA, SULFATE ION
Authors:Hunt, J.F, Weinkauf, S, Henry, L, Fak, J.J, McNicholas, P, Oliver, D.B, Deisenhofer, J.
Deposit date:2002-07-16
Release date:2002-09-20
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Nucleotide Control of Interdomain Interactions in the Conformational Reaction Cycle of SecA
Science, 297, 2002
1G31
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BU of 1g31 by Molmil
GP31 CO-CHAPERONIN FROM BACTERIOPHAGE T4
Descriptor: GP31, PHOSPHATE ION, POTASSIUM ION
Authors:Hunt, J.F, Van Der Vies, S.M, Henry, L, Deisenhofer, J.
Deposit date:1998-03-27
Release date:1998-08-26
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural adaptations in the specialized bacteriophage T4 co-chaperonin Gp31 expand the size of the Anfinsen cage.
Cell(Cambridge,Mass.), 90, 1997
4WA7
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BU of 4wa7 by Molmil
Crystal Structure of a GDP-bound Q61L Oncogenic Mutant of Human GT- Pase KRas
Descriptor: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
Authors:Hunter, J.C, Manandhar, A, Gurbani, D, Chen, Z, Westover, K.D.
Deposit date:2014-08-28
Release date:2015-06-10
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.986 Å)
Cite:Biochemical and Structural Analysis of Common Cancer-Associated KRAS Mutations.
Mol Cancer Res., 13, 2015
6RFK
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BU of 6rfk by Molmil
Crystal structure of EGRCK-inhibited Gla-domainless fIXa (K148Q, R150Q variant)
Descriptor: 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, Coagulation factor IX, ...
Authors:Huntington, J.A, Sendall, T.J.
Deposit date:2019-04-15
Release date:2019-06-12
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:NMR resonance assignments of apo and EGRCK-inhibited factor IXa
To Be Published
5NBV
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BU of 5nbv by Molmil
Crystal structure of native alpha-1-antitrypsin with seven stabilising mutations
Descriptor: Alpha-1-antitrypsin, GLYCEROL
Authors:Huntington, J.A, Pomowski, A, Johnson, D.J.D.
Deposit date:2017-03-02
Release date:2018-03-21
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:CRYSTAL STRUCTURE OF THE Z VARIANT OF ALPHA-1-ANTITRYPSIN REVEALS STRUCTURAL AND DYNAMICAL CHANGES AND SUPPORTS A C-TERMINAL DOMAIN SWAP MECHANISM OF POLYMERIZATION
To Be Published
5NBU
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BU of 5nbu by Molmil
Crystal structure of native alpha-1-antitrypsin with seven stabilising mutations
Descriptor: Alpha-1-antitrypsin, GLYCEROL, OXAMIC ACID
Authors:Huntington, J.A, Pomowski, A, Johnson, D.J.D.
Deposit date:2017-03-02
Release date:2018-03-21
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:CRYSTAL STRUCTURE OF THE Z VARIANT OF ALPHA-1-ANTITRYPSIN REVEALS STRUCTURAL AND DYNAMICAL CHANGES AND SUPPORTS A C-TERMINAL DOMAIN SWAP MECHANISM OF POLYMERIZATION
To Be Published
4LDJ
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BU of 4ldj by Molmil
Crystal Structure of a GDP-bound G12C Oncogenic Mutant of Human GTPase KRas
Descriptor: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
Authors:Hunter, J.C, Gurbani, D, Chen, Z, Westover, K.D.
Deposit date:2013-06-24
Release date:2014-06-04
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:In situ selectivity profiling and crystal structure of SML-8-73-1, an active site inhibitor of oncogenic K-Ras G12C.
Proc.Natl.Acad.Sci.USA, 111, 2014
1LQ8
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BU of 1lq8 by Molmil
Crystal structure of cleaved protein C inhibitor
Descriptor: 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Huntington, J.A, Kjellberg, M, Stenflo, J.
Deposit date:2002-05-09
Release date:2003-02-11
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structure of Protein C Inhibitor Provides Insights into Hormone Binding and Heparin Activation
Structure, 11, 2003
4NMM
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BU of 4nmm by Molmil
Crystal Structure of a G12C Oncogenic Variant of Human KRas Bound to a Novel GDP Competitive Covalent Inhibitor
Descriptor: 5'-O-[(S)-{[(S)-[2-(acetylamino)ethoxy](hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]guanosine, GTPase KRas, MAGNESIUM ION
Authors:Hunter, J.C, Gurbani, D, Lim, S.M, Westover, K.D.
Deposit date:2013-11-15
Release date:2014-06-04
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:In situ selectivity profiling and crystal structure of SML-8-73-1, an active site inhibitor of oncogenic K-Ras G12C.
Proc.Natl.Acad.Sci.USA, 111, 2014
4OBE
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BU of 4obe by Molmil
Crystal Structure of GDP-bound Human KRas
Descriptor: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
Authors:Hunter, J.C, Gurbani, D, Chen, Z, Westover, K.D.
Deposit date:2014-01-07
Release date:2014-06-04
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.24 Å)
Cite:In situ selectivity profiling and crystal structure of SML-8-73-1, an active site inhibitor of oncogenic K-Ras G12C.
Proc.Natl.Acad.Sci.USA, 111, 2014
1QMB
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BU of 1qmb by Molmil
Cleaved alpha-1-antitrypsin polymer
Descriptor: ALPHA-1-ANTITRYPSIN
Authors:Huntington, J.A, Pannu, N.S, Hazes, B, Read, R.J, Lomas, D.A, Carrell, R.W.
Deposit date:1999-09-24
Release date:2000-02-06
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:A 2.6A Structure of a Serpin Polymer and Implications for Conformational Disease
J.Mol.Biol., 293, 1999
4QL3
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BU of 4ql3 by Molmil
Crystal Structure of a GDP-bound G12R Oncogenic Mutant of Human GTPase KRas
Descriptor: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
Authors:Hunter, J.C, Manandhar, A, Gurbani, D, Chen, Z, Westover, K.D.
Deposit date:2014-06-10
Release date:2015-06-10
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.041 Å)
Cite:Biochemical and Structural Analysis of Common Cancer-Associated KRAS Mutations.
Mol Cancer Res., 13, 2015
3NDF
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BU of 3ndf by Molmil
Cleaved antitrypsin with P8-P6 Asp
Descriptor: Alpha-1-antitrypsin
Authors:Huntington, J.A, Sendall, T.J, Yamasaki, M.
Deposit date:2010-06-07
Release date:2010-07-28
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Loop-sheet mechanism of serpin polymerization tested by reactive center loop mutations
J. Biol. Chem., 285, 2010
3T1P
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BU of 3t1p by Molmil
Crystal structure of an alpha-1-antitrypsin trimer
Descriptor: Alpha-1-antitrypsin
Authors:Huntington, J.A, Yamasaki, M.
Deposit date:2011-07-22
Release date:2011-08-17
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.9 Å)
Cite:Molecular basis of alpha 1-antitrypsin deficiency revealed by the structure of a domain-swapped trimer.
EMBO Rep., 12, 2011
1NQ9
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BU of 1nq9 by Molmil
Crystal Structure of Antithrombin in the Pentasaccharide-Bound Intermediate State
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3,4-di-O-methyl-2,6-di-O-sulfo-alpha-D-glucopyranose-(1-4)-2,3-di-O-methyl-beta-D-glucopyranuronic acid-(1-4)-2,3,6-tri-O-sulfo-alpha-D-glucopyranose-(1-4)-3-O-methyl-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-methyl 2,3,6-tri-O-sulfo-alpha-D-glucopyranoside, ...
Authors:Huntington, J.A, Johnson, D.J.D.
Deposit date:2003-01-21
Release date:2003-09-30
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal Structure of Antithrombin in a Heparin-Bound Intermediate State
Biochemistry, 42, 2003
1JOU
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BU of 1jou by Molmil
Crystal Structure of Native S195A Thrombin with an Unoccupied Active Site
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETIC ACID, GLYCEROL, ...
Authors:Huntington, J.A, Esmon, C.T.
Deposit date:2001-07-31
Release date:2001-08-10
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The molecular basis of thrombin allostery revealed by a 1.8A structure of the slow form
Structure, 11, 2003
4TQ9
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BU of 4tq9 by Molmil
Crystal Structure of a GDP-bound G12V Oncogenic Mutant of Human GTPase KRas
Descriptor: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
Authors:Hunter, J.C, Manandhar, A, Gurbani, D, Chen, Z, Westover, K.D.
Deposit date:2014-06-10
Release date:2015-06-10
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.491 Å)
Cite:Biochemical and Structural Analysis of Common Cancer-Associated KRAS Mutations.
Mol Cancer Res., 13, 2015
4TQA
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BU of 4tqa by Molmil
Crystal Structure of a GDP-bound G13D Oncogenic Mutant of Human GTPase KRas
Descriptor: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
Authors:Hunter, J.C, Manandhar, A, Gurbani, D, Chen, Z, Westover, K.D.
Deposit date:2014-06-10
Release date:2015-06-10
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.13 Å)
Cite:Biochemical and Structural Analysis of Common Cancer-Associated KRAS Mutations.
Mol Cancer Res., 13, 2015
1EZX
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BU of 1ezx by Molmil
CRYSTAL STRUCTURE OF A SERPIN:PROTEASE COMPLEX
Descriptor: ALPHA-1-ANTITRYPSIN, TRYPSIN
Authors:Huntington, J.A, Carrell, R.W.
Deposit date:2000-05-12
Release date:2000-10-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of a serpin-protease complex shows inhibition by deformation.
Nature, 407, 2000
3EVJ
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BU of 3evj by Molmil
Intermediate structure of antithrombin bound to the natural pentasaccharide
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-4)-2-deoxy-3,6-di-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-methyl 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranoside, ...
Authors:Huntington, J.A, Belzar, K.J.
Deposit date:2008-10-13
Release date:2008-10-21
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3 Å)
Cite:The critical role of hinge-region expulsion in the induced-fit heparin binding mechanism of antithrombin.
J. Mol. Biol., 386, 2009
4DY0
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BU of 4dy0 by Molmil
Crystal structure of native protease nexin-1 with heparin
Descriptor: 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid, GLYCEROL, Glia-derived nexin, ...
Authors:Huntington, J.A, Li, W.
Deposit date:2012-02-28
Release date:2012-08-15
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Crystal structures of protease nexin-1 in complex with heparin and thrombin suggest a 2-step recognition mechanism.
Blood, 120, 2012
4DY7
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BU of 4dy7 by Molmil
Crystal structures of protease nexin-1 in complex with S195A thrombin
Descriptor: ACETATE ION, CALCIUM ION, Glia-derived nexin, ...
Authors:Huntington, J.A, Li, W.
Deposit date:2012-02-28
Release date:2012-08-15
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structures of protease nexin-1 in complex with heparin and thrombin suggest a 2-step recognition mechanism.
Blood, 120, 2012
3KCG
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BU of 3kcg by Molmil
Crystal structure of the antithrombin-factor IXa-pentasaccharide complex
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 3,4-di-O-methyl-2,6-di-O-sulfo-alpha-D-glucopyranose-(1-4)-2,3-di-O-methyl-beta-D-glucopyranuronic acid-(1-4)-2,3,6-tri-O-sulfo-alpha-D-glucopyranose-(1-4)-3-O-methyl-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-methyl 2,3,6-tri-O-sulfo-alpha-D-glucopyranoside, Antithrombin-III, ...
Authors:Huntington, J.A, Johnson, D.J.D.
Deposit date:2009-10-21
Release date:2010-02-02
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Molecular basis of factor IXa recognition by heparin-activated antithrombin revealed by a 1.7-A structure of the ternary complex.
Proc.Natl.Acad.Sci.USA, 107, 2010
1IY9
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BU of 1iy9 by Molmil
Crystal structure of spermidine synthase
Descriptor: Spermidine synthase
Authors:Tan, A.Y, Smith, P.C, Shen, J, Xiao, R, Acton, T, Rost, B, Montelione, G, Hunt, J.F, Northeast Structural Genomics Consortium (NESG)
Deposit date:2002-07-26
Release date:2002-10-30
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of spermidine synthase
To be Published

222036

数据于2024-07-03公开中

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