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PDB: 735 件
1M6N
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BU of 1m6n by Molmil
Crystal structure of the SecA translocation ATPase from Bacillus subtilis
分子名称: Preprotein translocase secA, SULFATE ION
著者Hunt, J.F, Weinkauf, S, Henry, L, Fak, J.J, McNicholas, P, Oliver, D.B, Deisenhofer, J.
登録日2002-07-16
公開日2002-09-20
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Nucleotide Control of Interdomain Interactions in the Conformational Reaction Cycle of SecA
Science, 297, 2002
1M74
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BU of 1m74 by Molmil
Crystal structure of Mg-ADP-bound SecA from Bacillus subtilis
分子名称: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Preprotein translocase secA, ...
著者Hunt, J.F, Weinkauf, S, Henry, L, Fak, J.J, McNicholas, P, Oliver, D.B, Deisenhofer, J.
登録日2002-07-16
公開日2002-09-20
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Nucleotide Control of Interdomain Interactions in the Conformational Reaction Cycle of SecA
Science, 297, 2002
1G31
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BU of 1g31 by Molmil
GP31 CO-CHAPERONIN FROM BACTERIOPHAGE T4
分子名称: GP31, PHOSPHATE ION, POTASSIUM ION
著者Hunt, J.F, Van Der Vies, S.M, Henry, L, Deisenhofer, J.
登録日1998-03-27
公開日1998-08-26
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural adaptations in the specialized bacteriophage T4 co-chaperonin Gp31 expand the size of the Anfinsen cage.
Cell(Cambridge,Mass.), 90, 1997
3EVJ
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BU of 3evj by Molmil
Intermediate structure of antithrombin bound to the natural pentasaccharide
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-4)-2-deoxy-3,6-di-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-methyl 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranoside, ...
著者Huntington, J.A, Belzar, K.J.
登録日2008-10-13
公開日2008-10-21
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献The critical role of hinge-region expulsion in the induced-fit heparin binding mechanism of antithrombin.
J. Mol. Biol., 386, 2009
1JOU
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BU of 1jou by Molmil
Crystal Structure of Native S195A Thrombin with an Unoccupied Active Site
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETIC ACID, GLYCEROL, ...
著者Huntington, J.A, Esmon, C.T.
登録日2001-07-31
公開日2001-08-10
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献The molecular basis of thrombin allostery revealed by a 1.8A structure of the slow form
Structure, 11, 2003
5NBV
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BU of 5nbv by Molmil
Crystal structure of native alpha-1-antitrypsin with seven stabilising mutations
分子名称: Alpha-1-antitrypsin, GLYCEROL
著者Huntington, J.A, Pomowski, A, Johnson, D.J.D.
登録日2017-03-02
公開日2018-03-21
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.73 Å)
主引用文献CRYSTAL STRUCTURE OF THE Z VARIANT OF ALPHA-1-ANTITRYPSIN REVEALS STRUCTURAL AND DYNAMICAL CHANGES AND SUPPORTS A C-TERMINAL DOMAIN SWAP MECHANISM OF POLYMERIZATION
To Be Published
6RFK
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BU of 6rfk by Molmil
Crystal structure of EGRCK-inhibited Gla-domainless fIXa (K148Q, R150Q variant)
分子名称: 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, Coagulation factor IX, ...
著者Huntington, J.A, Sendall, T.J.
登録日2019-04-15
公開日2019-06-12
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献NMR resonance assignments of apo and EGRCK-inhibited factor IXa
To Be Published
4WA7
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BU of 4wa7 by Molmil
Crystal Structure of a GDP-bound Q61L Oncogenic Mutant of Human GT- Pase KRas
分子名称: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
著者Hunter, J.C, Manandhar, A, Gurbani, D, Chen, Z, Westover, K.D.
登録日2014-08-28
公開日2015-06-10
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.986 Å)
主引用文献Biochemical and Structural Analysis of Common Cancer-Associated KRAS Mutations.
Mol Cancer Res., 13, 2015
4TQ9
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BU of 4tq9 by Molmil
Crystal Structure of a GDP-bound G12V Oncogenic Mutant of Human GTPase KRas
分子名称: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
著者Hunter, J.C, Manandhar, A, Gurbani, D, Chen, Z, Westover, K.D.
登録日2014-06-10
公開日2015-06-10
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.491 Å)
主引用文献Biochemical and Structural Analysis of Common Cancer-Associated KRAS Mutations.
Mol Cancer Res., 13, 2015
4TQA
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BU of 4tqa by Molmil
Crystal Structure of a GDP-bound G13D Oncogenic Mutant of Human GTPase KRas
分子名称: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
著者Hunter, J.C, Manandhar, A, Gurbani, D, Chen, Z, Westover, K.D.
登録日2014-06-10
公開日2015-06-10
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.13 Å)
主引用文献Biochemical and Structural Analysis of Common Cancer-Associated KRAS Mutations.
Mol Cancer Res., 13, 2015
5NBU
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BU of 5nbu by Molmil
Crystal structure of native alpha-1-antitrypsin with seven stabilising mutations
分子名称: Alpha-1-antitrypsin, GLYCEROL, OXAMIC ACID
著者Huntington, J.A, Pomowski, A, Johnson, D.J.D.
登録日2017-03-02
公開日2018-03-21
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.67 Å)
主引用文献CRYSTAL STRUCTURE OF THE Z VARIANT OF ALPHA-1-ANTITRYPSIN REVEALS STRUCTURAL AND DYNAMICAL CHANGES AND SUPPORTS A C-TERMINAL DOMAIN SWAP MECHANISM OF POLYMERIZATION
To Be Published
1NQ9
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BU of 1nq9 by Molmil
Crystal Structure of Antithrombin in the Pentasaccharide-Bound Intermediate State
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3,4-di-O-methyl-2,6-di-O-sulfo-alpha-D-glucopyranose-(1-4)-2,3-di-O-methyl-beta-D-glucopyranuronic acid-(1-4)-2,3,6-tri-O-sulfo-alpha-D-glucopyranose-(1-4)-3-O-methyl-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-methyl 2,3,6-tri-O-sulfo-alpha-D-glucopyranoside, ...
著者Huntington, J.A, Johnson, D.J.D.
登録日2003-01-21
公開日2003-09-30
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Crystal Structure of Antithrombin in a Heparin-Bound Intermediate State
Biochemistry, 42, 2003
1LQ8
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BU of 1lq8 by Molmil
Crystal structure of cleaved protein C inhibitor
分子名称: 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Huntington, J.A, Kjellberg, M, Stenflo, J.
登録日2002-05-09
公開日2003-02-11
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Crystal Structure of Protein C Inhibitor Provides Insights into Hormone Binding and Heparin Activation
Structure, 11, 2003
3T1P
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BU of 3t1p by Molmil
Crystal structure of an alpha-1-antitrypsin trimer
分子名称: Alpha-1-antitrypsin
著者Huntington, J.A, Yamasaki, M.
登録日2011-07-22
公開日2011-08-17
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (3.9 Å)
主引用文献Molecular basis of alpha 1-antitrypsin deficiency revealed by the structure of a domain-swapped trimer.
EMBO Rep., 12, 2011
1QMB
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BU of 1qmb by Molmil
Cleaved alpha-1-antitrypsin polymer
分子名称: ALPHA-1-ANTITRYPSIN
著者Huntington, J.A, Pannu, N.S, Hazes, B, Read, R.J, Lomas, D.A, Carrell, R.W.
登録日1999-09-24
公開日2000-02-06
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献A 2.6A Structure of a Serpin Polymer and Implications for Conformational Disease
J.Mol.Biol., 293, 1999
4LDJ
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BU of 4ldj by Molmil
Crystal Structure of a GDP-bound G12C Oncogenic Mutant of Human GTPase KRas
分子名称: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
著者Hunter, J.C, Gurbani, D, Chen, Z, Westover, K.D.
登録日2013-06-24
公開日2014-06-04
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.15 Å)
主引用文献In situ selectivity profiling and crystal structure of SML-8-73-1, an active site inhibitor of oncogenic K-Ras G12C.
Proc.Natl.Acad.Sci.USA, 111, 2014
4NMM
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BU of 4nmm by Molmil
Crystal Structure of a G12C Oncogenic Variant of Human KRas Bound to a Novel GDP Competitive Covalent Inhibitor
分子名称: 5'-O-[(S)-{[(S)-[2-(acetylamino)ethoxy](hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]guanosine, GTPase KRas, MAGNESIUM ION
著者Hunter, J.C, Gurbani, D, Lim, S.M, Westover, K.D.
登録日2013-11-15
公開日2014-06-04
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.89 Å)
主引用文献In situ selectivity profiling and crystal structure of SML-8-73-1, an active site inhibitor of oncogenic K-Ras G12C.
Proc.Natl.Acad.Sci.USA, 111, 2014
4OBE
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BU of 4obe by Molmil
Crystal Structure of GDP-bound Human KRas
分子名称: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
著者Hunter, J.C, Gurbani, D, Chen, Z, Westover, K.D.
登録日2014-01-07
公開日2014-06-04
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.24 Å)
主引用文献In situ selectivity profiling and crystal structure of SML-8-73-1, an active site inhibitor of oncogenic K-Ras G12C.
Proc.Natl.Acad.Sci.USA, 111, 2014
4QL3
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BU of 4ql3 by Molmil
Crystal Structure of a GDP-bound G12R Oncogenic Mutant of Human GTPase KRas
分子名称: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
著者Hunter, J.C, Manandhar, A, Gurbani, D, Chen, Z, Westover, K.D.
登録日2014-06-10
公開日2015-06-10
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.041 Å)
主引用文献Biochemical and Structural Analysis of Common Cancer-Associated KRAS Mutations.
Mol Cancer Res., 13, 2015
1EZX
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BU of 1ezx by Molmil
CRYSTAL STRUCTURE OF A SERPIN:PROTEASE COMPLEX
分子名称: ALPHA-1-ANTITRYPSIN, TRYPSIN
著者Huntington, J.A, Carrell, R.W.
登録日2000-05-12
公開日2000-10-25
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structure of a serpin-protease complex shows inhibition by deformation.
Nature, 407, 2000
4DY7
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BU of 4dy7 by Molmil
Crystal structures of protease nexin-1 in complex with S195A thrombin
分子名称: ACETATE ION, CALCIUM ION, Glia-derived nexin, ...
著者Huntington, J.A, Li, W.
登録日2012-02-28
公開日2012-08-15
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal structures of protease nexin-1 in complex with heparin and thrombin suggest a 2-step recognition mechanism.
Blood, 120, 2012
3KCG
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BU of 3kcg by Molmil
Crystal structure of the antithrombin-factor IXa-pentasaccharide complex
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 3,4-di-O-methyl-2,6-di-O-sulfo-alpha-D-glucopyranose-(1-4)-2,3-di-O-methyl-beta-D-glucopyranuronic acid-(1-4)-2,3,6-tri-O-sulfo-alpha-D-glucopyranose-(1-4)-3-O-methyl-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-methyl 2,3,6-tri-O-sulfo-alpha-D-glucopyranoside, Antithrombin-III, ...
著者Huntington, J.A, Johnson, D.J.D.
登録日2009-10-21
公開日2010-02-02
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Molecular basis of factor IXa recognition by heparin-activated antithrombin revealed by a 1.7-A structure of the ternary complex.
Proc.Natl.Acad.Sci.USA, 107, 2010
3NDF
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BU of 3ndf by Molmil
Cleaved antitrypsin with P8-P6 Asp
分子名称: Alpha-1-antitrypsin
著者Huntington, J.A, Sendall, T.J, Yamasaki, M.
登録日2010-06-07
公開日2010-07-28
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Loop-sheet mechanism of serpin polymerization tested by reactive center loop mutations
J. Biol. Chem., 285, 2010
4DY0
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BU of 4dy0 by Molmil
Crystal structure of native protease nexin-1 with heparin
分子名称: 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid, GLYCEROL, Glia-derived nexin, ...
著者Huntington, J.A, Li, W.
登録日2012-02-28
公開日2012-08-15
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Crystal structures of protease nexin-1 in complex with heparin and thrombin suggest a 2-step recognition mechanism.
Blood, 120, 2012
8GDY
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BU of 8gdy by Molmil
Crystal structure of the human PDI first domain with 9 mutations
分子名称: 1,2-ETHANEDIOL, Protein disulfide-isomerase, THIOCYANATE ION
著者Forouhar, F, Banayan, N.E, Loughlin, B.L, Singh, S, Wong, V, Hunt, H.S, Handelman, S.K, Price, N, Hunt, J.F.
登録日2023-03-06
公開日2024-01-24
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Systematic enhancement of protein crystallization efficiency by bulk lysine-to-arginine (KR) substitution.
Protein Sci., 33, 2024

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