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PDB: 122 件

4S2M
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Crystal Structure of OXA-163 complexed with iodide in the active site
分子名称: Beta-lactamase, IODIDE ION
著者Stojanoski, V, Hu, L, Palzkill, T.G, Prasad, B.
登録日2015-01-21
公開日2015-07-22
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.87 Å)
主引用文献Structural Basis for Different Substrate Profiles of Two Closely Related Class D beta-Lactamases and Their Inhibition by Halogens.
Biochemistry, 54, 2015
3OZJ
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BU of 3ozj by Molmil
Crystal structure of human retinoic X receptor alpha complexed with bigelovin and coactivator SRC-1
分子名称: (3aR,4S,4aR,7aR,8R,9aS)-4a,8-dimethyl-3-methylidene-2,5-dioxo-2,3,3a,4,4a,5,7a,8,9,9a-decahydroazuleno[6,5-b]furan-4-yl acetate, Retinoic acid receptor RXR-alpha, SRC-1, ...
著者Zhang, H, Li, L, Chen, L, Hu, L, Shen, X.
登録日2010-09-25
公開日2011-02-02
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structure basis of bigelovin as a selective RXR agonist with a distinct binding mode
J.Mol.Biol., 407, 2011
8ELA
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CTX-M-14 beta-lactamase mutant - N132A w MES
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Beta-lactamase, CHLORIDE ION, ...
著者Lu, S, Palzkill, T, Hu, L, Prasad, B.V.V.
登録日2022-09-23
公開日2023-04-05
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Mutagenesis and structural analysis reveal the CTX-M beta-lactamase active site is optimized for cephalosporin catalysis and drug resistance.
J.Biol.Chem., 299, 2023
6UVK
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OXA-48 bound by inhibitor CDD-97
分子名称: 1,2-ETHANEDIOL, 1-{4-[4-(2-ethoxyphenyl)piperazin-1-yl]-1,3,5-triazin-2-yl}piperidine-4-carboxylic acid, Beta-lactamase, ...
著者Taylor, D.M, Hu, L, Prasad, B.V.V, Sankaran, B, Palzkill, T.G.
登録日2019-11-02
公開日2020-05-06
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Identifying Oxacillinase-48 Carbapenemase Inhibitors Using DNA-Encoded Chemical Libraries.
Acs Infect Dis., 6, 2020
3R5N
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BU of 3r5n by Molmil
Crystal structure of PPARgammaLBD complexed with the agonist magnolol
分子名称: 5,5'-di(prop-2-en-1-yl)biphenyl-2,2'-diol, Peroxisome proliferator-activated receptor gamma
著者Zhang, H, Chen, L, Chen, J, Hu, L, Jiang, H, Shen, X.
登録日2011-03-18
公開日2012-02-08
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Molecular determinants of magnolol targeting both RXR(alpha) and PPAR(gamma).
Plos One, 6, 2011
3R5M
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Crystal structure of RXRalphaLBD complexed with the agonist magnolol
分子名称: 5,5'-di(prop-2-en-1-yl)biphenyl-2,2'-diol, Nuclear receptor coactivator 2, Retinoic acid receptor RXR-alpha
著者Zhang, H, Chen, L, Chen, J, Hu, L, Jiang, H, Shen, X.
登録日2011-03-18
公開日2012-02-08
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Molecular determinants of magnolol targeting both RXR(alpha) and PPAR(gamma).
Plos One, 6, 2011
6LK0
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BU of 6lk0 by Molmil
Crystal structure of human wild type TRIP13
分子名称: Pachytene checkpoint protein 2 homolog
著者Wang, Y, Huang, J, Li, B, Xue, H, Tricot, G, Hu, L, Xu, Z, Sun, X, Chang, S, Gao, L, Tao, Y, Xu, H, Xie, Y, Xiao, W, Yu, D, Kong, Y, Chen, G, Sun, X, Lian, F, Zhang, N, Wu, X, Mao, Z, Zhan, F, Zhu, W, Shi, J.
登録日2019-12-17
公開日2020-01-22
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献A Small-Molecule Inhibitor Targeting TRIP13 Suppresses Multiple Myeloma Progression.
Cancer Res., 80, 2020
5HAQ
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OXa-48 beta-lactamase mutant - S70G
分子名称: Beta-lactamase, CADMIUM ION, FORMIC ACID
著者Stojanoski, V, Adamski, C.J, Hu, L, Mehta, S.C, Sankaran, B, Prasad, B.V.V, Palzkill, T.G.
登録日2015-12-30
公開日2016-09-07
最終更新日2019-12-11
実験手法X-RAY DIFFRACTION (2.14 Å)
主引用文献Removal of the Side Chain at the Active-Site Serine by a Glycine Substitution Increases the Stability of a Wide Range of Serine beta-Lactamases by Relieving Steric Strain.
Biochemistry, 55, 2016
6V5E
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Crystal structure of CTX-M-14 P167S/D240G beta-lactamase
分子名称: Beta-lactamase
著者Brown, C.A, Hu, L, Sankaran, B, Prasad, B.V.V, Palzkill, T.G.
登録日2019-12-04
公開日2020-04-22
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Antagonism between substitutions in beta-lactamase explains a path not taken in the evolution of bacterial drug resistance.
J.Biol.Chem., 295, 2020
3N9L
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ceKDM7A from C.elegans, complex with H3K4me3 peptide and NOG
分子名称: FE (II) ION, Histone H3 peptide, N-OXALYLGLYCINE, ...
著者Yang, Y, Hu, L, Wang, P, Hou, H, Chen, C.D, Xu, Y.
登録日2010-05-31
公開日2010-06-30
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.796 Å)
主引用文献Structural insights into a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans
Cell Res., 20, 2010
3N9Q
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ceKDM7A from C.elegans, complex with H3K4me3 peptide, H3K27me2 peptide and NOG
分子名称: FE (II) ION, Histone H3 peptide, N-OXALYLGLYCINE, ...
著者Yang, Y, Hu, L, Wang, P, Hou, H, Chen, C.D, Xu, Y.
登録日2010-05-31
公開日2010-06-30
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural insights into a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans
Cell Res., 20, 2010
3N9N
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BU of 3n9n by Molmil
ceKDM7A from C.elegans, complex with H3K4me3K9me2 peptide and NOG
分子名称: FE (II) ION, Histone H3 peptide, N-OXALYLGLYCINE, ...
著者Yang, Y, Hu, L, Wang, P, Hou, H, Chen, C.D, Xu, Y.
登録日2010-05-31
公開日2010-06-30
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.299 Å)
主引用文献Structural insights into a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans
Cell Res., 20, 2010
7L8O
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BU of 7l8o by Molmil
OXA-48 bound by Compound 4.3
分子名称: 1,2-ETHANEDIOL, 9H-fluorene-2,7-disulfonate, Beta-lactamase, ...
著者Taylor, D.M, Hu, L, Prasad, B.V.V, Palzkill, T.
登録日2020-12-31
公開日2021-12-01
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Unique Diacidic Fragments Inhibit the OXA-48 Carbapenemase and Enhance the Killing of Escherichia coli Producing OXA-48.
Acs Infect Dis., 7, 2021
3N9M
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BU of 3n9m by Molmil
ceKDM7A from C.elegans, alone
分子名称: FE (II) ION, Putative uncharacterized protein, ZINC ION
著者Yang, Y, Hu, L, Wang, P, Hou, H, Chen, C.D, Xu, Y.
登録日2010-05-31
公開日2010-06-30
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.493 Å)
主引用文献Structural insights into a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans
Cell Res., 20, 2010
4RX2
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BU of 4rx2 by Molmil
A triple mutant in the omega-loop of TEM-1 beta-lactamase changes the substrate profile via a large conformational change and an altered general base for catalysis
分子名称: Beta-lactamase TEM, SULFATE ION
著者Stojanoski, V, Chow, D, Hu, L, Sankaran, B, Gilbert, H, Prasad, B.V.V, Palzkill, T.
登録日2014-12-08
公開日2015-03-04
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.315 Å)
主引用文献A Triple Mutant in the Omega-loop of TEM-1 beta-Lactamase Changes the Substrate Profile via a Large Conformational Change and an Altered General Base for Catalysis.
J.Biol.Chem., 290, 2015
3N9P
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BU of 3n9p by Molmil
ceKDM7A from C.elegans, complex with H3K4me3K27me2 peptide and NOG
分子名称: FE (II) ION, Histone H3 peptide, N-OXALYLGLYCINE, ...
著者Yang, Y, Hu, L, Wang, P, Hou, H, Chen, C.D, Xu, Y.
登録日2010-05-31
公開日2010-06-30
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.388 Å)
主引用文献Structural insights into a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans
Cell Res., 20, 2010
3N9O
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BU of 3n9o by Molmil
ceKDM7A from C.elegans, complex with H3K4me3 peptide, H3K9me2 peptide and NOG
分子名称: FE (II) ION, Histone H3 peptide, N-OXALYLGLYCINE, ...
著者Yang, Y, Hu, L, Wang, P, Hou, H, Chen, C.D, Xu, Y.
登録日2010-05-31
公開日2010-06-30
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.309 Å)
主引用文献Structural insights into a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans
Cell Res., 20, 2010
3PCU
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BU of 3pcu by Molmil
Crystal structure of human retinoic X receptor alpha ligand-binding domain complexed with LX0278 and SRC1 peptide
分子名称: 2-[(2S)-6-(2-methylbut-3-en-2-yl)-7-oxo-2,3-dihydro-7H-furo[3,2-g]chromen-2-yl]propan-2-yl acetate, Nuclear receptor coactivator 2, Retinoic acid receptor RXR-alpha
著者Zhang, H, Zhang, Y, Shen, H, Chen, J, Li, C, Chen, L, Hu, L, Jiang, H, Shen, X.
登録日2010-10-22
公開日2011-11-16
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献(+)-Rutamarin as a Dual Inducer of Both GLUT4 Translocation and Expression Efficiently Ameliorates Glucose Homeostasis in Insulin-Resistant Mice.
Plos One, 7, 2012
7DHR
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BU of 7dhr by Molmil
Cryo-EM structure of the full agonist isoprenaline-bound beta2 adrenergic receptor-Gs protein complex.
分子名称: Beta-2 adrenergic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Yang, F, Ling, S.L, Zhou, Y.X, Zhang, Y.N, Lv, P, Liu, S.L, Fang, W, Sun, W.J, Hu, L.Y.A.
登録日2020-11-17
公開日2020-12-16
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献Different Conformational Responses of the beta2-Adrenergic Receptor-Gs Complex upon Binding of the Partial Agonist Salbutamol or the Full Agonist Isoprenaline
Natl Sci Rev, 2020
7JIE
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BU of 7jie by Molmil
Structure of GII.4 P-domain in Complex with NORO-320 FAB
分子名称: IgA Fab Heavy Chain, IgA Fab Light Chain, VP1
著者Salmen, W, Hu, L, Prasad, B.
登録日2020-07-23
公開日2021-06-30
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.254 Å)
主引用文献Broadly cross-reactive human antibodies that inhibit genogroup I and II noroviruses.
Nat Commun, 12, 2021
7K5V
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BU of 7k5v by Molmil
OXA-48 bound by Compound 3.1
分子名称: 1,2-ETHANEDIOL, Beta-lactamase, CHLORIDE ION, ...
著者Taylor, D.M, Hu, L, Prasad, B.V.V, Palzkill, T.
登録日2020-09-17
公開日2021-12-01
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Unique Diacidic Fragments Inhibit the OXA-48 Carbapenemase and Enhance the Killing of Escherichia coli Producing OXA-48.
Acs Infect Dis., 7, 2021
6V6G
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BU of 6v6g by Molmil
Crystal structure of CTX-M-14 E166A/P167S/D240G beta-lactamase
分子名称: Beta-lactamase, DI(HYDROXYETHYL)ETHER, SODIUM ION
著者Brown, C.A, Hu, L, Sankaran, B, Prasad, B.V.V, Palzkill, T.G.
登録日2019-12-05
公開日2020-04-22
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Antagonism between substitutions in beta-lactamase explains a path not taken in the evolution of bacterial drug resistance.
J.Biol.Chem., 295, 2020
6V6P
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BU of 6v6p by Molmil
Crystal structure of CTX-M-14 E166A/D240G beta-lactamase
分子名称: Beta-lactamase, DI(HYDROXYETHYL)ETHER, SULFATE ION
著者Brown, C.A, Hu, L, Sankaran, B, Prasad, B.V.V, Palzkill, T.G.
登録日2019-12-05
公開日2020-04-22
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Antagonism between substitutions in beta-lactamase explains a path not taken in the evolution of bacterial drug resistance.
J.Biol.Chem., 295, 2020
6V8V
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Crystal structure of CTX-M-14 E166A/P167S/D240G beta-lactamase in complex with ceftazidime-2
分子名称: ACYLATED CEFTAZIDIME, Beta-lactamase
著者Brown, C.A, Hu, L, Sankaran, B, Prasad, B.V.V, Palzkill, T.G.
登録日2019-12-12
公開日2020-04-22
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Antagonism between substitutions in beta-lactamase explains a path not taken in the evolution of bacterial drug resistance.
J.Biol.Chem., 295, 2020
6V83
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Crystal structure of CTX-M-14 E166A/P167S/D240G beta-lactamase in complex with ceftazidime-1
分子名称: ACYLATED CEFTAZIDIME, Beta-lactamase
著者Brown, C.A, Hu, L, Sankaran, B, Prasad, B.V.V, Palzkill, T.G.
登録日2019-12-10
公開日2020-04-22
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Antagonism between substitutions in beta-lactamase explains a path not taken in the evolution of bacterial drug resistance.
J.Biol.Chem., 295, 2020

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件を2024-08-21に公開中

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