7DHR

Cryo-EM structure of the full agonist isoprenaline-bound beta2 adrenergic receptor-Gs protein complex.

Summary for 7DHR

• Entry DOI: 10.2210/pdb7dhr/pdb
• EMDB information: 30682
• Descriptor: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total)
• Functional Keywords: g protein coupled receptor, isoprenaline, complex, cryo-em, signaling protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 5
• Total formula weight: 151259.04

Authors

Yang, F.,Ling, S.L.,Zhou, Y.X.,Zhang, Y.N.,Lv, P.,Liu, S.L.,Fang, W.,Sun, W.J.,Hu, L.Y.A. (deposition date: 2020-11-17, release date: 2020-12-16)

• Primary citation: Yang, F.,Ling, S.L.,Zhou, Y.X.,Zhang, Y.N.,Lv, P.,Liu, S.L.,Fang, W.,Sun, W.J.,Hu, L.Y.A.,Zhang, L.,Shi, P.,Tian, C.; Different Conformational Responses of the beta2-Adrenergic Receptor-Gs Complex upon Binding of the Partial Agonist Salbutamol or the Full Agonist Isoprenaline; Natl Sci Rev, 2020; DOI: 10.1093/nsr/nwaa284

Experimental method

ELECTRON MICROSCOPY (3.8 Å)