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3OZJ

Crystal structure of human retinoic X receptor alpha complexed with bigelovin and coactivator SRC-1

Summary for 3OZJ
Entry DOI10.2210/pdb3ozj/pdb
DescriptorRetinoic acid receptor RXR-alpha, SRC-1, peptide of Nuclear receptor coactivator 2, (3aR,4S,4aR,7aR,8R,9aS)-4a,8-dimethyl-3-methylidene-2,5-dioxo-2,3,3a,4,4a,5,7a,8,9,9a-decahydroazuleno[6,5-b]furan-4-yl acetate, ... (4 entities in total)
Functional Keywordsnuclear receptor ligand-binding domain, ligand-binding and transactivation, transcription
Biological sourceHomo sapiens (human)
More
Cellular locationNucleus: P19793 Q15596
Total number of polymer chains4
Total formula weight56755.81
Authors
Zhang, H.,Li, L.,Chen, L.,Hu, L.,Shen, X. (deposition date: 2010-09-25, release date: 2011-02-02, Last modification date: 2023-11-01)
Primary citationZhang, H.,Li, L.,Chen, L.,Hu, L.,Jiang, H.,Shen, X.
Structure basis of bigelovin as a selective RXR agonist with a distinct binding mode
J.Mol.Biol., 407:13-20, 2011
Cited by
PubMed: 21262235
DOI: 10.1016/j.jmb.2011.01.032
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.1 Å)
Structure validation

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