6V83

Crystal structure of CTX-M-14 E166A/P167S/D240G beta-lactamase in complex with ceftazidime-1

Summary for 6V83

Entry DOI	10.2210/pdb6v83/pdb
Related	6V5E
Descriptor	Beta-lactamase, ACYLATED CEFTAZIDIME (3 entities in total)
Functional Keywords	drug resistance, protein evolution, conformational change, enzyme kinetics, enzyme catalysis, protein stability, protein-drug interaction, hydrolase
Biological source	Escherichia coli
Total number of polymer chains	1
Total formula weight	28343.93
Authors	Brown, C.A.,Hu, L.,Sankaran, B.,Prasad, B.V.V.,Palzkill, T.G. (deposition date: 2019-12-10, release date: 2020-04-22, Last modification date: 2023-10-11)
Primary citation	Brown, C.A.,Hu, L.,Sun, Z.,Patel, M.P.,Singh, S.,Porter, J.R.,Sankaran, B.,Prasad, B.V.V.,Bowman, G.R.,Palzkill, T. Antagonism between substitutions in beta-lactamase explains a path not taken in the evolution of bacterial drug resistance. J.Biol.Chem., 295:7376-7390, 2020 Cited by PubMed: 32299911 DOI: 10.1074/jbc.RA119.012489 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation