7L8O

OXA-48 bound by Compound 4.3

Summary for 7L8O

Entry DOI	10.2210/pdb7l8o/pdb
Descriptor	Beta-lactamase, 1,2-ETHANEDIOL, 9H-fluorene-2,7-disulfonate, ... (6 entities in total)
Functional Keywords	beta-lactamase, carbapenemase, beta-lactamase inhibitor, complex, oxacillinase, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor
Biological source	Klebsiella pneumoniae
Total number of polymer chains	4
Total formula weight	115189.29
Authors	Taylor, D.M.,Hu, L.,Prasad, B.V.V.,Palzkill, T. (deposition date: 2020-12-31, release date: 2021-12-01, Last modification date: 2023-11-15)
Primary citation	Taylor, D.M.,Anglin, J.,Hu, L.,Wang, L.,Sankaran, B.,Wang, J.,Matzuk, M.M.,Prasad, B.V.V.,Palzkill, T. Unique Diacidic Fragments Inhibit the OXA-48 Carbapenemase and Enhance the Killing of Escherichia coli Producing OXA-48. Acs Infect Dis., 7:3345-3354, 2021 Cited by PubMed: 34817169 DOI: 10.1021/acsinfecdis.1c00501 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation