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PDB: 231 件
2ZO0
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mouse NP95 SRA domain DNA specific complex 1
分子名称: DNA (5'-D(*DGP*DTP*DCP*DAP*DGP*(5CM)P*DGP*DCP*DAP*DAP*DTP*DGP*DG)-3'), DNA (5'-D(*DTP*DCP*DCP*DAP*DTP*DGP*DCP*DGP*DCP*DTP*DGP*DAP*DC)-3'), E3 ubiquitin-protein ligase UHRF1
著者Hashimoto, H, Horton, J.R, Cheng, X.
登録日2008-05-05
公開日2008-09-09
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.19 Å)
主引用文献The SRA domain of UHRF1 flips 5-methylcytosine out of the DNA helix
Nature, 455, 2008
1U2Z
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BU of 1u2z by Molmil
Crystal structure of histone K79 methyltransferase Dot1p from yeast
分子名称: Histone-lysine N-methyltransferase, H3 lysine-79 specific, S-ADENOSYL-L-HOMOCYSTEINE
著者Sawada, K, Yang, Z, Horton, J.R, Collins, R.E, Zhang, X, Cheng, X.
登録日2004-07-20
公開日2004-09-07
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structure of the conserved core of the yeast Dot1p, a nucleosomal histone H3 lysine 79 methyltransferase
J.Biol.Chem., 279, 2004
3F8I
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Mouse UHRF1 SRA domain bound with hemi-methylated CpG, crystal structure in space group P21
分子名称: 5'-D(*DCP*DCP*DAP*DTP*DGP*(5CM)P*DGP*DCP*DTP*DGP*DAP*DC)-3', 5'-D(*DGP*DTP*DCP*DAP*DGP*DCP*DGP*DCP*DAP*DTP*DGP*DG)-3', E3 ubiquitin-protein ligase UHRF1
著者Hashimoto, H, Horton, J.R, Zhang, X, Cheng, X.
登録日2008-11-12
公開日2009-01-06
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.29 Å)
主引用文献UHRF1, a modular multi-domain protein, regulates replication-coupled crosstalk between DNA methylation and histone modifications.
Epigenetics, 4, 2009
3FDE
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BU of 3fde by Molmil
Mouse UHRF1 SRA domain bound with hemi-methylated CpG DNA, crystal structure in space group C222(1) at 1.4 A resolution
分子名称: 1,2-ETHANEDIOL, 5'-D(*CP*CP*AP*TP*GP*(5CM)P*GP*CP*TP*GP*AP*C)-3', 5'-D(*GP*TP*CP*AP*GP*CP*GP*CP*AP*TP*GP*G)-3', ...
著者Hashimoto, H, Horton, J.R, Zhang, X, Cheng, X.
登録日2008-11-25
公開日2009-01-06
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.41 Å)
主引用文献UHRF1, a modular multi-domain protein, regulates replication-coupled crosstalk between DNA methylation and histone modifications.
Epigenetics, 4, 2009
3F8J
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BU of 3f8j by Molmil
Mouse UHRF1 SRA domain bound with hemi-methylated CpG, crystal structure in space group C222(1)
分子名称: 5'-D(*DCP*DCP*DAP*DTP*DGP*(5CM)P*DGP*DCP*DTP*DGP*DAP*DC)-3', 5'-D(*DGP*DTP*DCP*DAP*DGP*DCP*DGP*DCP*DAP*DTP*DGP*DG)-3', E3 ubiquitin-protein ligase UHRF1, ...
著者Hashimoto, H, Horton, J.R, Zhang, X, Cheng, X.
登録日2008-11-12
公開日2009-01-06
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.99 Å)
主引用文献UHRF1, a modular multi-domain protein, regulates replication-coupled crosstalk between DNA methylation and histone modifications.
Epigenetics, 4, 2009
8FS2
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BU of 8fs2 by Molmil
CamA Adenine Methyltransferase Complexed to Cognate Substrate DNA and Inhibitor 11b (YD907)
分子名称: 1,2-ETHANEDIOL, 5'-S-{3-[N'-(cyclohexylmethyl)carbamimidamido]propyl}-N-(3-phenylpropyl)-5'-thioadenosine, DNA (5'-D(*TP*TP*CP*AP*AP*AP*AP*AP*GP*TP*CP*CP*CP*A)-3'), ...
著者Zhou, J, Horton, J.R, Cheng, X.
登録日2023-01-09
公開日2023-05-10
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.59 Å)
主引用文献Comparative Study of Adenosine Analogs as Inhibitors of Protein Arginine Methyltransferases and a Clostridioides difficile- Specific DNA Adenine Methyltransferase.
Acs Chem.Biol., 18, 2023
3SVM
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BU of 3svm by Molmil
Human MPP8 - human DNMT3AK47me2 peptide
分子名称: DNA (cytosine-5)-methyltransferase 3A, M-phase phosphoprotein 8
著者Chang, Y, Horton, J.R, Zhang, X, Cheng, X.
登録日2011-07-12
公開日2011-11-30
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.31 Å)
主引用文献MPP8 mediates the interactions between DNA methyltransferase Dnmt3a and H3K9 methyltransferase GLP/G9a.
Nat Commun, 2, 2011
3SWC
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BU of 3swc by Molmil
GLP (G9a-like protein) SET domain in complex with Dnmt3aK44me2 peptide
分子名称: DNA (cytosine-5)-methyltransferase 3A, Histone-lysine N-methyltransferase EHMT1, S-ADENOSYL-L-HOMOCYSTEINE, ...
著者Chang, Y, Horton, J.R, Zhang, X, Cheng, X.
登録日2011-07-13
公開日2011-11-30
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.332 Å)
主引用文献MPP8 mediates the interactions between DNA methyltransferase Dnmt3a and H3K9 methyltransferase GLP/G9a.
Nat Commun, 2, 2011
5EH2
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Human PRDM9 allele-A ZnF Domain with Associated Recombination Hotspot DNA Sequence III
分子名称: DNA (5'-D(*AP*CP*AP*CP*GP*TP*GP*GP*CP*TP*AP*GP*GP*GP*AP*GP*GP*CP*CP*TP*C)-3'), DNA (5'-D(*TP*GP*AP*GP*GP*CP*CP*TP*CP*CP*CP*TP*AP*GP*CP*CP*AP*CP*GP*TP*G)-3'), Histone-lysine N-methyltransferase PRDM9, ...
著者Patel, A, Horton, J.R, Wilson, G.G, Zhang, X, Cheng, X.
登録日2015-10-27
公開日2016-02-17
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Structural basis for human PRDM9 action at recombination hot spots.
Genes Dev., 30, 2016
5EI9
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BU of 5ei9 by Molmil
Human PRDM9 allele-A ZnF Domain with Associated Recombination Hotspot DNA Sequence I
分子名称: DNA (5'-D(*AP*TP*CP*CP*AP*CP*GP*TP*GP*GP*CP*TP*AP*GP*GP*GP*AP*GP*GP*CP*C)-3'), DNA (5'-D(*TP*GP*GP*CP*CP*TP*CP*CP*CP*TP*AP*GP*CP*CP*AP*CP*GP*TP*GP*GP*A)-3'), Histone-lysine N-methyltransferase PRDM9, ...
著者Patel, A, Horton, J.R, Wilson, G.G, Zhang, X, Cheng, X.
登録日2015-10-29
公開日2016-02-17
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (1.921 Å)
主引用文献Structural basis for human PRDM9 action at recombination hot spots.
Genes Dev., 30, 2016
5EGB
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BU of 5egb by Molmil
Human PRDM9 allele-A ZnF Domain with Associated Recombination Hotspot DNA Sequence II
分子名称: DNA (5'-D(*AP*CP*CP*AP*CP*GP*TP*GP*GP*CP*TP*AP*GP*GP*GP*AP*GP*GP*CP*CP*T)-3'), DNA (5'-D(*TP*AP*GP*GP*CP*CP*TP*CP*CP*CP*TP*AP*GP*CP*CP*AP*CP*GP*TP*GP*G)-3'), Histone-lysine N-methyltransferase PRDM9, ...
著者Patel, A, Horton, J.R, Wilson, G.G, Zhang, X, Cheng, X.
登録日2015-10-26
公開日2016-02-17
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (1.977 Å)
主引用文献Structural basis for human PRDM9 action at recombination hot spots.
Genes Dev., 30, 2016
3SW9
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BU of 3sw9 by Molmil
GLP (G9a-like protein) SET domain in complex with Dnmt3aK44me0 peptide
分子名称: DNA (cytosine-5)-methyltransferase 3A, Histone-lysine N-methyltransferase EHMT1, SINEFUNGIN, ...
著者Chang, Y, Horton, J.R, Zhang, X, Cheng, X.
登録日2011-07-13
公開日2011-12-07
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (3.05 Å)
主引用文献MPP8 mediates the interactions between DNA methyltransferase Dnmt3a and H3K9 methyltransferase GLP/G9a.
Nat Commun, 2, 2011
5T01
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BU of 5t01 by Molmil
Human c-Jun DNA binding domain homodimer in complex with methylated DNA
分子名称: DNA (5'-D(*AP*AP*TP*GP*GP*AP*(5CM)P*GP*AP*GP*TP*CP*AP*TP*AP*GP*GP*AP*G)-3'), DNA (5'-D(P*CP*TP*CP*CP*TP*AP*TP*GP*AP*CP*TP*CP*GP*TP*CP*CP*AP*T)-3'), Transcription factor AP-1
著者Hong, S, Horton, J.R, Cheng, X.
登録日2016-08-15
公開日2017-03-01
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.89 Å)
主引用文献Methyl-dependent and spatial-specific DNA recognition by the orthologous transcription factors human AP-1 and Epstein-Barr virus Zta.
Nucleic Acids Res., 45, 2017
5SZX
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BU of 5szx by Molmil
Epstein-Barr virus Zta DNA binding domain homodimer in complex with methylated DNA
分子名称: DNA (5'-D(*AP*AP*GP*CP*AP*CP*TP*GP*AP*GP*(5CM)P*GP*AP*TP*GP*AP*AP*G)-3'), DNA (5'-D(*TP*CP*TP*TP*CP*AP*TP*(5CM)P*GP*CP*TP*CP*AP*GP*TP*GP*CP*T)-3'), PHOSPHATE ION, ...
著者Hong, S, Horton, J.R, Cheng, X.
登録日2016-08-15
公開日2017-03-01
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.251 Å)
主引用文献Methyl-dependent and spatial-specific DNA recognition by the orthologous transcription factors human AP-1 and Epstein-Barr virus Zta.
Nucleic Acids Res., 45, 2017
6V62
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BU of 6v62 by Molmil
SETD3 double mutant (N255F/W273A) in Complex with an Actin Peptide with His73 Replaced with Lysine
分子名称: 1,2-ETHANEDIOL, Actin, cytoplasmic 1, ...
著者Dai, S, Horton, J.R, Cheng, X.
登録日2019-12-04
公開日2020-01-15
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.36 Å)
主引用文献An engineered variant of SETD3 methyltransferase alters target specificity from histidine to lysine methylation.
J.Biol.Chem., 295, 2020
6V63
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BU of 6v63 by Molmil
SETD3 WT in Complex with an Actin Peptide with His73 Replaced with Glutamine
分子名称: 1,2-ETHANEDIOL, ACETATE ION, Actin, ...
著者Dai, S, Horton, J.R, Cheng, X.
登録日2019-12-04
公開日2020-01-22
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.02 Å)
主引用文献An engineered variant of SETD3 methyltransferase alters target specificity from histidine to lysine methylation.
J.Biol.Chem., 295, 2020
6WK2
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BU of 6wk2 by Molmil
SETD3 mutant (N255V) in Complex with an Actin Peptide with His73 Replaced with Methionine
分子名称: 1,2-ETHANEDIOL, Actin, cytoplasmic 2, ...
著者Dai, S, Horton, J.R, Cheng, X.
登録日2020-04-15
公開日2020-06-17
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.76 Å)
主引用文献Characterization of SETD3 methyltransferase-mediated protein methionine methylation.
J.Biol.Chem., 295, 2020
6WMI
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ZNF410 zinc fingers 1-5 with 17 mer blunt DNA Oligonucleotide
分子名称: 1,2-ETHANEDIOL, DNA (5'-D(*CP*AP*CP*AP*TP*CP*CP*CP*AP*TP*AP*AP*TP*AP*AP*TP*G)-3'), DNA (5'-D(*CP*AP*TP*TP*AP*TP*TP*AP*TP*GP*GP*GP*AP*TP*GP*TP*G)-3'), ...
著者Ren, R, Horton, J.R, Cheng, X.
登録日2020-04-21
公開日2020-12-09
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献ZNF410 Uniquely Activates the NuRD Component CHD4 to Silence Fetal Hemoglobin Expression.
Mol.Cell, 81, 2021
6WK1
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BU of 6wk1 by Molmil
SETD3 in Complex with an Actin Peptide with His73 Replaced with Methionine
分子名称: 1,2-ETHANEDIOL, ACETATE ION, Actin, ...
著者Dai, S, Horton, J.R, Cheng, X.
登録日2020-04-15
公開日2020-06-17
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.89 Å)
主引用文献Characterization of SETD3 methyltransferase-mediated protein methionine methylation.
J.Biol.Chem., 295, 2020
6X9I
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Human DNMT1(729-1600) Bound to Zebularine-Containing 12mer dsDNA
分子名称: 1,2-ETHANEDIOL, DNA (5'-D(*GP*AP*GP*GP*CP*(5CM)P*GP*CP*CP*TP*GP*C)-3'), DNA (5'-D(*GP*CP*AP*GP*G)-R(P*(PYO))-D(P*GP*GP*CP*CP*TP*C)-3'), ...
著者Pathuri, S, Horton, J.R, Cheng, X.
登録日2020-06-02
公開日2021-07-07
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Discovery of a first-in-class reversible DNMT1-selective inhibitor with improved tolerability and efficacy in acute myeloid leukemia.
Nat Cancer, 2, 2021
6X9K
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BU of 6x9k by Molmil
Human DNMT1(729-1600) Bound to Zebularine-Containing 12mer dsDNA and Inhibitor GSK3685032A
分子名称: (2R)-2-{[6-(4-aminopiperidin-1-yl)-3,5-dicyano-4-ethylpyridin-2-yl]sulfanyl}-2-phenylacetamide, 1,2-ETHANEDIOL, DNA (5'-D(*GP*AP*GP*GP*CP*(5CM)P*GP*CP*CP*TP*GP*C)-3'), ...
著者Pathuri, S, Horton, J.R, Cheng, X.
登録日2020-06-02
公開日2021-07-07
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Discovery of a first-in-class reversible DNMT1-selective inhibitor with improved tolerability and efficacy in acute myeloid leukemia.
Nat Cancer, 2, 2021
6X9J
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BU of 6x9j by Molmil
Human DNMT1(729-1600) Bound to Zebularine-Containing 12mer dsDNA and Inhibitor GSK3830052
分子名称: 1,2-ETHANEDIOL, DNA (5'-D(*GP*AP*GP*GP*CP*(5CM)P*GP*CP*CP*TP*GP*C)-3'), DNA (5'-D(*GP*CP*AP*GP*G)-R(P*(PYO))-D(P*GP*GP*CP*CP*TP*C)-3'), ...
著者Pathuri, S, Horton, J.R, Cheng, X.
登録日2020-06-02
公開日2021-07-07
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.79 Å)
主引用文献Discovery of a first-in-class reversible DNMT1-selective inhibitor with improved tolerability and efficacy in acute myeloid leukemia.
Nat Cancer, 2, 2021
1ML9
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BU of 1ml9 by Molmil
Structure of the Neurospora SET domain protein DIM-5, a histone lysine methyltransferase
分子名称: Histone H3 methyltransferase DIM-5, UNKNOWN, ZINC ION
著者Zhang, X, Tamaru, H, Khan, S.I, Horton, J.R, Keefe, L.J, Selker, E.U, Cheng, X.
登録日2002-08-30
公開日2002-10-23
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.98 Å)
主引用文献Structure of the Neurospora SET domain protein DIM-5, a histone H3 lysine methyltransferase
Cell(Cambridge,Mass.), 111, 2002
3B95
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EuHMT1 (Glp) Ankyrin Repeat Domain (Structure 2)
分子名称: Euchromatic histone-lysine N-methyltransferase 1, Histone H3 N-terminal Peptide, SULFATE ION
著者Collins, R.E, Horton, J.R, Cheng, X.
登録日2007-11-02
公開日2008-02-12
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.99 Å)
主引用文献The ankyrin repeats of G9a and GLP histone methyltransferases are mono- and dimethyllysine binding modules.
Nat.Struct.Mol.Biol., 15, 2008
1MOZ
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BU of 1moz by Molmil
ADP-ribosylation factor-like 1 (ARL1) from Saccharomyces cerevisiae
分子名称: ADP-ribosylation factor-like protein 1, GUANOSINE-5'-DIPHOSPHATE
著者Amor, J.C, Horton, J.R, Zhu, X, Wang, Y, Sullards, C, Ringe, D, Cheng, X, Kahn, R.A.
登録日2002-09-10
公開日2002-10-09
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (3.17 Å)
主引用文献Structures of Yeast ARF2 and ARL1: DISTINCT ROLES FOR THE N TERMINUS IN THE STRUCTURE AND FUNCTION OF ARF FAMILY GTPases
J.Biol.Chem., 276, 2001

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