3F8J
Mouse UHRF1 SRA domain bound with hemi-methylated CpG, crystal structure in space group C222(1)
Summary for 3F8J
Entry DOI | 10.2210/pdb3f8j/pdb |
Related | 2ZO0 2ZO1 2ZO2 3F8I |
Descriptor | E3 ubiquitin-protein ligase UHRF1, 5'-D(*DCP*DCP*DAP*DTP*DGP*(5CM)P*DGP*DCP*DTP*DGP*DAP*DC)-3', 5'-D(*DGP*DTP*DCP*DAP*DGP*DCP*DGP*DCP*DAP*DTP*DGP*DG)-3', ... (5 entities in total) |
Functional Keywords | uhrf1, sra, base flipping, 5-methylcytosine, cpg methylation, cell cycle, developmental protein, dna damage, dna repair, dna-binding, ligase, metal-binding, nucleus, phosphoprotein, transcription, transcription regulation, ubl conjugation pathway, zinc-finger, ligase-dna complex, ligase/dna |
Biological source | Mus musculus (house mouse) More |
Cellular location | Nucleus: Q8VDF2 |
Total number of polymer chains | 3 |
Total formula weight | 32028.31 |
Authors | Hashimoto, H.,Horton, J.R.,Zhang, X.,Cheng, X. (deposition date: 2008-11-12, release date: 2009-01-06, Last modification date: 2023-09-06) |
Primary citation | Hashimoto, H.,Horton, J.R.,Zhang, X.,Cheng, X. UHRF1, a modular multi-domain protein, regulates replication-coupled crosstalk between DNA methylation and histone modifications. Epigenetics, 4:8-14, 2009 Cited by PubMed: 19077538PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.99 Å) |
Structure validation
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