3F8J
Mouse UHRF1 SRA domain bound with hemi-methylated CpG, crystal structure in space group C222(1)
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B 191 |
| Chain | Residue |
| B | HOH72 |
| B | HOH79 |
| B | HOH126 |
| B | GLY469 |
| B | ASP474 |
| B | GLY545 |
| B | HIS548 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL B 192 |
| Chain | Residue |
| B | GLN504 |
| B | LYS505 |
| B | LEU506 |
| B | TRP580 |
| B | HOH69 |
| B | HOH157 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL B 193 |
| Chain | Residue |
| B | ARG558 |
| B | PRO593 |
| B | LYS599 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B 194 |
| Chain | Residue |
| B | HOH119 |
| B | HOH134 |
| B | PRO425 |
| B | ILE562 |
| B | ASP587 |
| B | ASP588 |
| B | THR589 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL B 195 |
| Chain | Residue |
| B | HOH144 |
| B | GOL196 |
| B | PHE423 |
| B | PRO536 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL B 196 |
| Chain | Residue |
| B | HOH110 |
| B | HOH119 |
| B | GOL195 |
| B | PRO536 |
| B | LYS564 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL B 197 |
| Chain | Residue |
| B | HOH12 |
| B | ASN479 |
| B | ARG585 |
| B | ARG586 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL B 198 |
| Chain | Residue |
| B | HOH38 |
| B | ASP530 |
| B | ARG532 |
| B | ARG601 |
| B | GLN604 |
| F | DC402 |
| site_id | AC9 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GOL B 199 |
| Chain | Residue |
| B | HOH121 |
| B | ASN421 |
| B | ARG457 |
| B | ASN459 |
| B | ASP460 |
| B | TYR463 |
| B | ASP473 |
| B | GLY573 |
| B | LYS574 |
| B | ARG581 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| B | ALA468 | |
| B | ASP474 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | SITE: Required to confer preferential recognition of cytosine over thymine => ECO:0000250 |
| Chain | Residue | Details |
| B | THR484 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | SITE: Required to discriminate between hemimethylated DNA versus symmetrically methylated DNA |
| Chain | Residue | Details |
| B | ASN494 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | SITE: Required for affinity and specificity for 5-mCpG sequence |
| Chain | Residue | Details |
| B | ARG496 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:21183079 |
| Chain | Residue | Details |
| B | SER519 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine; alternate => ECO:0000250|UniProtKB:Q96T88 |
| Chain | Residue | Details |
| B | LYS550 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0000250|UniProtKB:Q96T88 |
| Chain | Residue | Details |
| B | LYS550 |
