3F8J
Mouse UHRF1 SRA domain bound with hemi-methylated CpG, crystal structure in space group C222(1)
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B 191 |
| Chain | Residue |
| B | HOH72 |
| B | HOH79 |
| B | HOH126 |
| B | GLY469 |
| B | ASP474 |
| B | GLY545 |
| B | HIS548 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL B 192 |
| Chain | Residue |
| B | GLN504 |
| B | LYS505 |
| B | LEU506 |
| B | TRP580 |
| B | HOH69 |
| B | HOH157 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL B 193 |
| Chain | Residue |
| B | ARG558 |
| B | PRO593 |
| B | LYS599 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B 194 |
| Chain | Residue |
| B | HOH119 |
| B | HOH134 |
| B | PRO425 |
| B | ILE562 |
| B | ASP587 |
| B | ASP588 |
| B | THR589 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL B 195 |
| Chain | Residue |
| B | HOH144 |
| B | GOL196 |
| B | PHE423 |
| B | PRO536 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL B 196 |
| Chain | Residue |
| B | HOH110 |
| B | HOH119 |
| B | GOL195 |
| B | PRO536 |
| B | LYS564 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL B 197 |
| Chain | Residue |
| B | HOH12 |
| B | ASN479 |
| B | ARG585 |
| B | ARG586 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL B 198 |
| Chain | Residue |
| B | HOH38 |
| B | ASP530 |
| B | ARG532 |
| B | ARG601 |
| B | GLN604 |
| F | DC402 |
| site_id | AC9 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GOL B 199 |
| Chain | Residue |
| B | HOH121 |
| B | ASN421 |
| B | ARG457 |
| B | ASN459 |
| B | ASP460 |
| B | TYR463 |
| B | ASP473 |
| B | GLY573 |
| B | LYS574 |
| B | ARG581 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 162 |
| Details | Domain: {"description":"YDG","evidences":[{"source":"PROSITE-ProRule","id":"PRU00358","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Region: {"description":"Required to promote base flipping"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Region: {"description":"Required for formation of a 5-methylcytosine-binding pocket"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Site: {"description":"Required to confer preferential recognition of cytosine over thymine","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Site: {"description":"Required to discriminate between hemimethylated DNA versus symmetrically methylated DNA"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Site: {"description":"Required for affinity and specificity for 5-mCpG sequence"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"21183079","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"UniProtKB","id":"Q96T88","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"UniProtKB","id":"Q96T88","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
