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PDB: 155 results

4UNT
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BU of 4unt by Molmil
Induced monomer of the Mcg variable domain
Descriptor: IG LAMBDA CHAIN V-II REGION MGC, SULFATE ION
Authors:Brumshtein, B, Esswein, S.R, Landau, M, Ryan, C.M, Whitelegge, J.P, Phillips, M.L, Cascio, D, Sawaya, M.R, Eisenberg, D.S.
Deposit date:2014-05-30
Release date:2014-08-27
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Formation of Amyloid Fibers by Monomeric Light-Chain Variable Domains.
J.Biol.Chem., 289, 2014
5TVO
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BU of 5tvo by Molmil
Crystal structure of Trypanosoma brucei AdoMetDC-delta26 monomer
Descriptor: S-adenosylmethionine decarboxylase alpha chain, S-adenosylmethionine decarboxylase proenzyme, SODIUM ION
Authors:Volkov, O.A, Ariagno, C, Chen, Z, Tomchick, D.R, Phillips, M.A.
Deposit date:2016-11-09
Release date:2016-12-28
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (1.481 Å)
Cite:Relief of autoinhibition by conformational switch explains enzyme activation by a catalytically dead paralog.
Elife, 5, 2016
4QR9
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BU of 4qr9 by Molmil
Crystal structure of two HMGB1 Box A domains cooperating to underwind and kink a DNA
Descriptor: DNA (5'-D(*AP*TP*AP*TP*CP*GP*AP*TP*AP*T)-3'), High mobility group protein B1, MAGNESIUM ION
Authors:Sanchez-Giraldo, R, Acosta-Reyes, F.J, Malarkey, C.S, Saperas, N, Churchill, M.E.A, Campos, J.L.
Deposit date:2014-06-30
Release date:2015-07-01
Last modified:2024-10-09
Method:X-RAY DIFFRACTION (2 Å)
Cite:Two high-mobility group box domains act together to underwind and kink DNA.
Acta Crystallogr.,Sect.D, 71, 2015
6DFT
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BU of 6dft by Molmil
Trypanosoma brucei deoxyhypusine synthase
Descriptor: Deoxyhypusine synthase, Deoxyhypusine synthase regulatory subunit, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
Authors:Tomchick, D.R, Phillips, M.A, Afanador, G.A.
Deposit date:2018-05-15
Release date:2018-08-08
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Trypanosomatid Deoxyhypusine Synthase Activity Is Dependent on Shared Active-Site Complementation between Pseudoenzyme Paralogs.
Structure, 26, 2018
6BM7
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BU of 6bm7 by Molmil
Crystal structure of Trypanosoma brucei AdoMetDC/prozyme heterodimer in complex with pyrimidineamine inhibitor UTSAM568
Descriptor: 1,4-DIAMINOBUTANE, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-amino-4-[(3,5-dibromophenyl)amino]-6-methylpyrimidin-1-ium, ...
Authors:Volkov, O.A, Chen, Z, Phillips, M.A.
Deposit date:2017-11-13
Release date:2018-01-03
Last modified:2024-10-09
Method:X-RAY DIFFRACTION (2.98 Å)
Cite:Species-Selective Pyrimidineamine Inhibitors of Trypanosoma brucei S-Adenosylmethionine Decarboxylase.
J. Med. Chem., 61, 2018
5TVM
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BU of 5tvm by Molmil
Crystal structure of Trypanosoma brucei AdoMetDC/prozyme heterodimer
Descriptor: 1,4-DIAMINOBUTANE, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, S-adenosylmethionine decarboxylase alpha chain, ...
Authors:Volkov, O.A, Chen, Z, Tomchick, D.R, Phillips, M.A.
Deposit date:2016-11-09
Release date:2017-01-11
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.408 Å)
Cite:Relief of autoinhibition by conformational switch explains enzyme activation by a catalytically dead paralog.
Elife, 5, 2016
5ACM
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BU of 5acm by Molmil
Mcg immunoglobulin variable domain with methylene blue
Descriptor: 3,7-BIS(DIMETHYLAMINO)PHENOTHIAZIN-5-IUM, GLYCEROL, MCG, ...
Authors:Brumshtein, B, Esswein, S.R, Salwinski, L, Phillips, M.L, Ly, A.T, Cascio, D, Sawaya, M.R, Eisenberg, D.S.
Deposit date:2015-08-17
Release date:2015-12-02
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.05 Å)
Cite:Inhibition by small-molecule ligands of formation of amyloid fibrils of an immunoglobulin light chain variable domain.
Elife, 4, 2015
6E0B
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BU of 6e0b by Molmil
Plasmodium falciparum dihydroorotate dehydrogenase C276F mutant bound with triazolopyrimidine-based inhibitor DSM1
Descriptor: 5-methyl-7-(naphthalen-2-ylamino)-1H-[1,2,4]triazolo[1,5-a]pyrimidine-3,8-diium, Dihydroorotate dehydrogenase (quinone), mitochondrial, ...
Authors:Tomchick, D.R, Phillips, M.A, Deng, X.
Deposit date:2018-07-06
Release date:2018-11-14
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.099 Å)
Cite:Identification and Mechanistic Understanding of Dihydroorotate Dehydrogenase Point Mutations in Plasmodium falciparum that Confer in Vitro Resistance to the Clinical Candidate DSM265.
ACS Infect Dis, 5, 2019
5ACL
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BU of 5acl by Molmil
Mcg immunoglobulin variable domain with sulfasalazine
Descriptor: 2-HYDROXY-(5-([4-(2-PYRIDINYLAMINO)SULFONYL]PHENYL)AZO)BENZOIC ACID, MCG, SULFATE ION
Authors:Brumshtein, B, Esswein, S.R, Salwinski, L, Phillips, M.L, Ly, A.T, Cascio, D, Sawaya, M.R, Eisenberg, D.S.
Deposit date:2015-08-17
Release date:2015-12-02
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:Inhibition by small-molecule ligands of formation of amyloid fibrils of an immunoglobulin light chain variable domain.
Elife, 4, 2015
3N2O
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BU of 3n2o by Molmil
X-ray crystal structure of arginine decarboxylase complexed with Arginine from Vibrio vulnificus
Descriptor: AGMATINE, Biosynthetic arginine decarboxylase, PYRIDOXAL-5'-PHOSPHATE
Authors:Deng, X, Lee, J, Michael, A.J, Tomchick, D.R, Goldsmith, E.J, Phillips, M.A.
Deposit date:2010-05-18
Release date:2010-06-09
Last modified:2012-02-22
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Evolution of substrate specificity within a diverse family of beta/alpha-barrel-fold basic amino acid decarboxylases: X-ray structure determination of enzymes with specificity for L-arginine and carboxynorspermidine.
J.Biol.Chem., 285, 2010
3QH9
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BU of 3qh9 by Molmil
Human Liprin-beta2 Coiled-Coil
Descriptor: AMMONIUM ION, GLYCEROL, IODIDE ION, ...
Authors:Stafford, R.L, Tang, M, Phillips, M.L, Bowie, J.U.
Deposit date:2011-01-25
Release date:2011-10-26
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Crystal structure of the central coiled-coil domain from human liprin-beta2
Biochemistry, 50, 2011
5TBO
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BU of 5tbo by Molmil
Crystal structure of Plasmodium falciparum dihydroorotate dehydrogenase bound with Inhibitor DSM421
Descriptor: 2-(1,1-difluoroethyl)-5-methyl-N-[6-(trifluoromethyl)pyridin-3-yl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine, Dihydroorotate dehydrogenase (quinone), mitochondrial, ...
Authors:Deng, X, Phillips, M.
Deposit date:2016-09-12
Release date:2016-09-28
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.151 Å)
Cite:A Triazolopyrimidine-Based Dihydroorotate Dehydrogenase Inhibitor with Improved Drug-like Properties for Treatment and Prevention of Malaria.
ACS Infect Dis, 2, 2016
3N29
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BU of 3n29 by Molmil
Crystal structure of carboxynorspermidine decarboxylase complexed with Norspermidine from Campylobacter jejuni
Descriptor: Carboxynorspermidine decarboxylase, GLYCEROL, N-(3-aminopropyl)propane-1,3-diamine, ...
Authors:Deng, X, Lee, J, Michael, A.J, Tomchick, D.R, Goldsmith, E.J, Phillips, M.A.
Deposit date:2010-05-17
Release date:2010-06-09
Last modified:2012-02-22
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Evolution of substrate specificity within a diverse family of beta/alpha-barrel-fold basic amino acid decarboxylases: X-ray structure determination of enzymes with specificity for L-arginine and carboxynorspermidine.
J.Biol.Chem., 285, 2010
3MAZ
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BU of 3maz by Molmil
Crystal Structure of the Human BRDG1/STAP-1 SH2 Domain in Complex with the NTAL pTyr136 Peptide
Descriptor: CheD family protein, MALONATE ION, Signal-transducing adaptor protein 1
Authors:Kaneko, T, Huang, H, Zhao, B, Li, L, Liu, H, Voss, C.K, Wu, C, Schiller, M.R, Li, S.S.
Deposit date:2010-03-24
Release date:2010-05-12
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Loops govern SH2 domain specificity by controlling access to binding pockets.
Sci.Signal., 3, 2010
3PLS
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BU of 3pls by Molmil
RON in complex with ligand AMP-PNP
Descriptor: MAGNESIUM ION, Macrophage-stimulating protein receptor, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Wang, J, Steinbacher, S, Augustin, M, Schreiner, P, Epstein, D, Mulvihill, M.J, Crew, A.P.
Deposit date:2010-11-15
Release date:2010-11-24
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:The Crystal Structure of a Constitutively Active Mutant RON Kinase Suggests an Intramolecular Autophosphorylation Hypothesis
Biochemistry, 49, 2010
1JI7
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BU of 1ji7 by Molmil
Crystal Structure of TEL SAM Polymer
Descriptor: ETS-RELATED PROTEIN TEL1, SULFATE ION
Authors:Kim, C.A, Phillips, M.L, Kim, W, Gingery, M, Tran, H.H, Robinson, M.A, Faham, S, Bowie, J.U.
Deposit date:2001-06-29
Release date:2002-07-03
Last modified:2022-12-21
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Polymerization of the SAM domain of TEL in leukemogenesis and transcriptional repression.
EMBO J., 20, 2001
3FGH
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BU of 3fgh by Molmil
Human mitochondrial transcription factor A box B
Descriptor: CADMIUM ION, CHLORIDE ION, SODIUM ION, ...
Authors:Gangelhoff, T.A, Mungalachetty, P, Nix, J, Churchill, M.E.A.
Deposit date:2008-12-06
Release date:2009-04-07
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Structural analysis and DNA binding of the HMG domains of the human mitochondrial transcription factor A
Nucleic Acids Res., 37, 2009
3ZEV
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BU of 3zev by Molmil
Structure of Thermostable Agonist-bound Neurotensin Receptor 1 Mutant without Lysozyme Fusion
Descriptor: GLYCINE, NEUROTENSIN, NEUROTENSIN RECEPTOR 1 TM86V
Authors:Egloff, P, Hillenbrand, M, Schlinkmann, K.M, Batyuk, A, Mittl, P, Plueckthun, A.
Deposit date:2012-12-07
Release date:2014-01-29
Last modified:2014-02-26
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of Signaling-Competent Neurotensin Receptor 1 Obtained by Directed Evolution in Escherichia Coli
Proc.Natl.Acad.Sci.USA, 111, 2014
1HMA
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BU of 1hma by Molmil
THE SOLUTION STRUCTURE AND DYNAMICS OF THE DNA BINDING DOMAIN OF HMG-D FROM DROSOPHILA MELANOGASTER
Descriptor: HMG-D
Authors:Jones, D.N.M, Searles, M.A, Shaw, G.L, Churchill, M.E.A, Ner, S.S, Keeler, J, Travers, A.A, Neuhaus, D.
Deposit date:1994-05-12
Release date:1994-07-31
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:The solution structure and dynamics of the DNA-binding domain of HMG-D from Drosophila melanogaster.
Structure, 2, 1994
3I6R
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BU of 3i6r by Molmil
Plasmodium falciparum dihydroorotate dehydrogenase bound with triazolopyrimidine-based inhibitor DSM74
Descriptor: 5-methyl-N-[4-(trifluoromethyl)phenyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine, Dihydroorotate dehydrogenase homolog, mitochondrial, ...
Authors:Deng, X, Phillips, M.A.
Deposit date:2009-07-07
Release date:2009-07-28
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural plasticity of malaria dihydroorotate dehydrogenase allows selective binding of diverse chemical scaffolds.
J.Biol.Chem., 284, 2009
3I65
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BU of 3i65 by Molmil
Plasmodium falciparum dihydroorotate dehydrogenase bound with triazolopyrimidine-based inhibitor DSM1
Descriptor: 5-methyl-7-(naphthalen-2-ylamino)-1H-[1,2,4]triazolo[1,5-a]pyrimidine-3,8-diium, Dihydroorotate dehydrogenase homolog, mitochondrial, ...
Authors:Deng, X, Phillips, M.A.
Deposit date:2009-07-06
Release date:2009-07-28
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural plasticity of malaria dihydroorotate dehydrogenase allows selective binding of diverse chemical scaffolds.
J.Biol.Chem., 284, 2009
3I68
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BU of 3i68 by Molmil
Plasmodium falciparum dihydroorotate dehydrogenase bound with triazolopyrimidine-based inhibitor DSM2
Descriptor: Dihydroorotate dehydrogenase homolog, mitochondrial, FLAVIN MONONUCLEOTIDE, ...
Authors:Deng, X, Phillips, M.A.
Deposit date:2009-07-06
Release date:2009-07-28
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural plasticity of malaria dihydroorotate dehydrogenase allows selective binding of diverse chemical scaffolds.
J.Biol.Chem., 284, 2009
4BV0
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BU of 4bv0 by Molmil
High Resolution Structure of Evolved Agonist-bound Neurotensin Receptor 1 Mutant without Lysozyme Fusion
Descriptor: NEUROTENSIN RECEPTOR TYPE 1, NEUROTENSIN/NEUROMEDIN N
Authors:Egloff, P, Hillenbrand, M, Scott, D.J, Schlinkmann, K.M, Heine, P, Balada, S, Batyuk, A, Mittl, P, Schuetz, M, Plueckthun, A.
Deposit date:2013-06-24
Release date:2014-01-29
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure of Signaling-Competent Neurotensin Receptor 1 Obtained by Directed Evolution in Escherichia Coli
Proc.Natl.Acad.Sci.USA, 111, 2014
4BUO
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BU of 4buo by Molmil
High Resolution Structure of Thermostable Agonist-bound Neurotensin Receptor 1 Mutant without Lysozyme Fusion
Descriptor: GLYCINE, NEUROTENSIN RECEPTOR TYPE 1, NEUROTENSIN/NEUROMEDIN N
Authors:Egloff, P, Hillenbrand, M, Schlinkmann, K.M, Batyuk, A, Mittl, P, Plueckthun, A.
Deposit date:2013-06-21
Release date:2014-01-29
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structure of Signaling-Competent Neurotensin Receptor 1 Obtained by Directed Evolution in Escherichia Coli
Proc.Natl.Acad.Sci.USA, 111, 2014
4BWB
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BU of 4bwb by Molmil
Structure of Evolved Agonist-bound Neurotensin Receptor 1 Mutant without Lysozyme Fusion
Descriptor: NEUROTENSIN, NEUROTENSIN RECEPTOR TYPE 1
Authors:Egloff, P, Hillenbrand, M, Scott, D.J, Schlinkmann, K.M, Heine, P, Balada, S, Batyuk, A, Mittl, P, Plueckthun, A.
Deposit date:2013-07-01
Release date:2014-01-29
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (3.57 Å)
Cite:Structure of Signaling-Competent Neurotensin Receptor 1 Obtained by Directed Evolution in Escherichia Coli
Proc.Natl.Acad.Sci.USA, 111, 2014

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數據於2024-11-06公開中

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