6BM7
Crystal structure of Trypanosoma brucei AdoMetDC/prozyme heterodimer in complex with pyrimidineamine inhibitor UTSAM568
Summary for 6BM7
Entry DOI | 10.2210/pdb6bm7/pdb |
Descriptor | S-adenosylmethionine decarboxylase beta chain, S-adenosylmethionine decarboxylase alpha chain, Inactive S-adenosylmethionine decarboxylase prozyme, ... (9 entities in total) |
Functional Keywords | adometdc, prozyme, decarboxylase, trypanosoma, inhibitor, lyase-lyase inhibitor complex, lyase/lyase inhibitor |
Biological source | Trypanosoma brucei brucei (strain 927/4 GUTat10.1) More |
Total number of polymer chains | 6 |
Total formula weight | 158233.26 |
Authors | Volkov, O.A.,Chen, Z.,Phillips, M.A. (deposition date: 2017-11-13, release date: 2018-01-03, Last modification date: 2023-11-15) |
Primary citation | Volkov, O.A.,Brockway, A.J.,Wring, S.A.,Peel, M.,Chen, Z.,Phillips, M.A.,De Brabander, J.K. Species-Selective Pyrimidineamine Inhibitors of Trypanosoma brucei S-Adenosylmethionine Decarboxylase. J. Med. Chem., 61:1182-1203, 2018 Cited by PubMed: 29271204DOI: 10.1021/acs.jmedchem.7b01654 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.98 Å) |
Structure validation
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