6BM7
Crystal structure of Trypanosoma brucei AdoMetDC/prozyme heterodimer in complex with pyrimidineamine inhibitor UTSAM568
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | S-adenosylmethionine decarboxylase beta chain | polymer | 85 | 9754.1 | 2 | UniProt (Q587A7) | Trypanosoma brucei brucei (strain 927/4 GUTat10.1) | |
| 2 | B, D (B, D) | S-adenosylmethionine decarboxylase alpha chain | polymer | 285 | 32042.0 | 2 | UniProt (Q587A7) Pfam (PF01536) | Trypanosoma brucei brucei (strain 927/4 GUTat10.1) | |
| 3 | E, F (E, F) | Inactive S-adenosylmethionine decarboxylase prozyme | polymer | 325 | 36343.7 | 2 | UniProt (A5HNV6) Pfam (PF01536) | Trypanosoma brucei brucei (strain 927/4 GUTat10.1) | AdoMetDC prozyme |
| 4 | G, I (B, D) | 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 282.3 | 2 | Chemie (B3P) | |||
| 5 | H, J (B, D) | 2-amino-4-[(3,5-dibromophenyl)amino]-6-methylpyrimidin-1-ium | non-polymer | 359.0 | 2 | Chemie (DY7) | |||
| 6 | K, N (E, F) | 1,4-DIAMINOBUTANE | non-polymer | 88.2 | 2 | Chemie (PUT) | |||
| 7 | L, M (E) | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 2 | Chemie (PGE) | |||
| 8 | O (F) | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 1 | Chemie (PG4) | |||
| 9 | P, Q, R, S, T (A, B, C, D, F) | water | water | 18.0 | 7 | Chemie (HOH) |
Sequence modifications
B, D: 87 - 370 (UniProt: Q587A7)
| PDB | External Database | Details |
|---|---|---|
| Pyr 86 | - | modified residue |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 156279.6 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1953.6 | |
| All* | Total formula weight | 158233.3 |
