6BM7

Crystal structure of Trypanosoma brucei AdoMetDC/prozyme heterodimer in complex with pyrimidineamine inhibitor UTSAM568

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004014	molecular_function	adenosylmethionine decarboxylase activity
A	0008295	biological_process	spermidine biosynthetic process
B	0004014	molecular_function	adenosylmethionine decarboxylase activity
B	0008295	biological_process	spermidine biosynthetic process
C	0004014	molecular_function	adenosylmethionine decarboxylase activity
C	0008295	biological_process	spermidine biosynthetic process
D	0004014	molecular_function	adenosylmethionine decarboxylase activity
D	0008295	biological_process	spermidine biosynthetic process
E	0004014	molecular_function	adenosylmethionine decarboxylase activity
E	0005829	cellular_component	cytosol
E	0006597	biological_process	spermine biosynthetic process
E	0008047	molecular_function	enzyme activator activity
E	0008295	biological_process	spermidine biosynthetic process
E	0019342	biological_process	trypanothione biosynthetic process
E	0019899	molecular_function	enzyme binding
E	0043085	biological_process	positive regulation of catalytic activity
E	0046500	biological_process	S-adenosylmethionine metabolic process
E	0046982	molecular_function	protein heterodimerization activity
E	1901307	biological_process	positive regulation of spermidine biosynthetic process
E	1902494	cellular_component	catalytic complex
F	0004014	molecular_function	adenosylmethionine decarboxylase activity
F	0005829	cellular_component	cytosol
F	0006597	biological_process	spermine biosynthetic process
F	0008047	molecular_function	enzyme activator activity
F	0008295	biological_process	spermidine biosynthetic process
F	0019342	biological_process	trypanothione biosynthetic process
F	0019899	molecular_function	enzyme binding
F	0043085	biological_process	positive regulation of catalytic activity
F	0046500	biological_process	S-adenosylmethionine metabolic process
F	0046982	molecular_function	protein heterodimerization activity
F	1901307	biological_process	positive regulation of spermidine biosynthetic process
F	1902494	cellular_component	catalytic complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	binding site for residue B3P B 401

Chain	Residue
A	GLU36
B	ALA190
B	ASP306
B	TYR341
A	ILE38
B	ARG94
B	GLU124
B	TRP125
B	SER185
B	CYS186
B	SER187
B	ASP189

---

site_id	AC2
Number of Residues	8
Details	binding site for residue DY7 B 402

Chain	Residue
B	CYS100
B	CYS246
B	TYR248
B	SER249
B	ILE263
B	THR264
B	PRO265
B	GLU266

---

site_id	AC3
Number of Residues	12
Details	binding site for residue B3P D 401

Chain	Residue
C	GLU36
C	ILE38
D	GLU124
D	VAL181
D	SER185
D	CYS186
D	SER187
D	ASP189
D	ALA190
D	PHE304
D	ASP306
D	TYR341

---

site_id	AC4
Number of Residues	8
Details	binding site for residue DY7 D 402

Chain	Residue
C	GLU85
D	CYS100
D	CYS246
D	SER249
D	HIS262
D	THR264
D	PRO265
D	GLU266

---

site_id	AC5
Number of Residues	7
Details	binding site for residue PUT E 401

Chain	Residue
E	GLU42
E	ASN44
E	TRP126
E	GLU193
E	ASP195
E	ASP282
E	TYR314

---

site_id	AC6
Number of Residues	4
Details	binding site for residue PGE E 402

Chain	Residue
E	VAL124
E	TYR180
E	GLY182
E	ASP184

---

site_id	AC7
Number of Residues	3
Details	binding site for residue PGE E 403

Chain	Residue
E	HIS111
E	HIS150
E	GLU154

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site_id	AC8
Number of Residues	7
Details	binding site for residue PUT F 401

Chain	Residue
F	GLU42
F	ASN44
F	TRP126
F	GLU193
F	ASP195
F	ASP282
F	TYR314

---

site_id	AC9
Number of Residues	6
Details	binding site for residue PG4 F 402

Chain	Residue
F	ILE123
F	VAL124
F	TYR180
F	GLY182
F	ILE183
F	ASP184

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