6BM7
Crystal structure of Trypanosoma brucei AdoMetDC/prozyme heterodimer in complex with pyrimidineamine inhibitor UTSAM568
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004014 | molecular_function | adenosylmethionine decarboxylase activity |
A | 0008295 | biological_process | spermidine biosynthetic process |
B | 0004014 | molecular_function | adenosylmethionine decarboxylase activity |
B | 0008295 | biological_process | spermidine biosynthetic process |
C | 0004014 | molecular_function | adenosylmethionine decarboxylase activity |
C | 0008295 | biological_process | spermidine biosynthetic process |
D | 0004014 | molecular_function | adenosylmethionine decarboxylase activity |
D | 0008295 | biological_process | spermidine biosynthetic process |
E | 0004014 | molecular_function | adenosylmethionine decarboxylase activity |
E | 0008047 | molecular_function | enzyme activator activity |
E | 0008295 | biological_process | spermidine biosynthetic process |
E | 0019342 | biological_process | trypanothione biosynthetic process |
E | 0019899 | molecular_function | enzyme binding |
E | 0043085 | biological_process | positive regulation of catalytic activity |
E | 0046500 | biological_process | S-adenosylmethionine metabolic process |
E | 0046982 | molecular_function | protein heterodimerization activity |
E | 1901307 | biological_process | positive regulation of spermidine biosynthetic process |
E | 1902494 | cellular_component | catalytic complex |
F | 0004014 | molecular_function | adenosylmethionine decarboxylase activity |
F | 0008047 | molecular_function | enzyme activator activity |
F | 0008295 | biological_process | spermidine biosynthetic process |
F | 0019342 | biological_process | trypanothione biosynthetic process |
F | 0019899 | molecular_function | enzyme binding |
F | 0043085 | biological_process | positive regulation of catalytic activity |
F | 0046500 | biological_process | S-adenosylmethionine metabolic process |
F | 0046982 | molecular_function | protein heterodimerization activity |
F | 1901307 | biological_process | positive regulation of spermidine biosynthetic process |
F | 1902494 | cellular_component | catalytic complex |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 12 |
Details | binding site for residue B3P B 401 |
Chain | Residue |
A | GLU36 |
B | ALA190 |
B | ASP306 |
B | TYR341 |
A | ILE38 |
B | ARG94 |
B | GLU124 |
B | TRP125 |
B | SER185 |
B | CYS186 |
B | SER187 |
B | ASP189 |
site_id | AC2 |
Number of Residues | 8 |
Details | binding site for residue DY7 B 402 |
Chain | Residue |
B | CYS100 |
B | CYS246 |
B | TYR248 |
B | SER249 |
B | ILE263 |
B | THR264 |
B | PRO265 |
B | GLU266 |
site_id | AC3 |
Number of Residues | 12 |
Details | binding site for residue B3P D 401 |
Chain | Residue |
C | GLU36 |
C | ILE38 |
D | GLU124 |
D | VAL181 |
D | SER185 |
D | CYS186 |
D | SER187 |
D | ASP189 |
D | ALA190 |
D | PHE304 |
D | ASP306 |
D | TYR341 |
site_id | AC4 |
Number of Residues | 8 |
Details | binding site for residue DY7 D 402 |
Chain | Residue |
C | GLU85 |
D | CYS100 |
D | CYS246 |
D | SER249 |
D | HIS262 |
D | THR264 |
D | PRO265 |
D | GLU266 |
site_id | AC5 |
Number of Residues | 7 |
Details | binding site for residue PUT E 401 |
Chain | Residue |
E | GLU42 |
E | ASN44 |
E | TRP126 |
E | GLU193 |
E | ASP195 |
E | ASP282 |
E | TYR314 |
site_id | AC6 |
Number of Residues | 4 |
Details | binding site for residue PGE E 402 |
Chain | Residue |
E | VAL124 |
E | TYR180 |
E | GLY182 |
E | ASP184 |
site_id | AC7 |
Number of Residues | 3 |
Details | binding site for residue PGE E 403 |
Chain | Residue |
E | HIS111 |
E | HIS150 |
E | GLU154 |
site_id | AC8 |
Number of Residues | 7 |
Details | binding site for residue PUT F 401 |
Chain | Residue |
F | GLU42 |
F | ASN44 |
F | TRP126 |
F | GLU193 |
F | ASP195 |
F | ASP282 |
F | TYR314 |
site_id | AC9 |
Number of Residues | 6 |
Details | binding site for residue PG4 F 402 |
Chain | Residue |
F | ILE123 |
F | VAL124 |
F | TYR180 |
F | GLY182 |
F | ILE183 |
F | ASP184 |