Crystal structure of two HMGB1 Box A domains cooperating to underwind and kink a DNA

Summary for 4QR9

DescriptorHigh mobility group protein B1, DNA (5'-D(*AP*TP*AP*TP*CP*GP*AP*TP*AP*T)-3'), MAGNESIUM ION, ... (4 entities in total)
Functional Keywordshmg-box, hmgb1, box a domain, high mobility group, dna-binding, bend dna, kink dna, architectural factor, minor groove, chromatin, nucleus, dna binding protein
Biological sourceRattus norvegicus (brown rat,rat,rats)
Cellular locationNucleus P63159
Total number of polymer chains6
Total molecular weight30095.03
Sanchez-Giraldo, R.,Acosta-Reyes, F.J.,Malarkey, C.S.,Saperas, N.,Churchill, M.E.A.,Campos, J.L. (deposition date: 2014-06-30, release date: 2015-07-01, Last modification date: 2015-07-29)
Primary citation
Sanchez-Giraldo, R.,Acosta-Reyes, F.J.,Malarkey, C.S.,Saperas, N.,Churchill, M.E.,Campos, J.L.
Two high-mobility group box domains act together to underwind and kink DNA.
Acta Crystallogr.,Sect.D, 71:1423-1432, 2015
PubMed: 26143914 (PDB entries with the same primary citation)
DOI: 10.1107/S1399004715007452
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.2355001.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-08-12