4QR9

Crystal structure of two HMGB1 Box A domains cooperating to underwind and kink a DNA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0005634	cellular_component	nucleus
B	0003677	molecular_function	DNA binding
B	0005634	cellular_component	nucleus

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG D 101

Chain	Residue
C	HOH107
C	HOH113
C	HOH116
D	HOH205
D	HOH226
D	HOH227

---

Functional Information from PROSITE/UniProt

site_id	PS00353
Number of Residues	12
Details	HMG_BOX_1 HMG box A DNA-binding domain signature. FSKKCsERWKTM

Chain	Residue	Details
A	PHE40-MET51

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	140
Details	DNA_BIND: HMG box 1 => ECO:0000255|PROSITE-ProRule:PRU00267

Chain	Residue	Details
A	PRO8-ILE78
B	PRO8-ILE78

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	SITE: Cleavage; by thrombin:thrombomodulin => ECO:0000250|UniProtKB:P10103

Chain	Residue	Details
A	ARG9
B	ARG9

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	SITE: Cleavage; by CASP1 => ECO:0000250|UniProtKB:P09429

Chain	Residue	Details
A	ASP66
B	ASP66

---

site_id	SWS_FT_FI4
Number of Residues	10
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P10103

Chain	Residue	Details
A	LYS7
B	LYS29
A	LYS11
A	LYS27
A	LYS28
A	LYS29
B	LYS7
B	LYS11
B	LYS27
B	LYS28

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: Cysteine sulfonic acid (-SO3H); alternate => ECO:0000305|PubMed:22869893

Chain	Residue	Details
A	CYS22
A	CYS44
B	CYS22
B	CYS44

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P09429

Chain	Residue	Details
A	SER34
B	SER34

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P63158

Chain	Residue	Details
A	LYS42
B	LYS42

---

site_id	SWS_FT_FI8
Number of Residues	10
Details	CROSSLNK: Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-?) => ECO:0000250|UniProtKB:P09429

Chain	Residue	Details
A	LYS27
B	LYS67
A	LYS42
A	LYS43
A	LYS67
B	LYS27
B	LYS42
B	LYS43

---