7Z75
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7z75 by Molmil](/molmil-images/mine/7z75) | PI3KC2a core in complex with PITCOIN3 | 分子名称: | 1,2-ETHANEDIOL, Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha, SULFATE ION, ... | 著者 | Lo, W.T, Roske, Y, Daumke, O, Haucke, V. | 登録日 | 2022-03-15 | 公開日 | 2022-08-31 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.59 Å) | 主引用文献 | Development of selective inhibitors of phosphatidylinositol 3-kinase C2 alpha. Nat.Chem.Biol., 19, 2023
|
|
7Z74
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7z74 by Molmil](/molmil-images/mine/7z74) | PI3KC2a core in complex with PITCOIN2 | 分子名称: | 1,2-ETHANEDIOL, Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha, ~{N}-[4-(3-hydroxyphenyl)-1,3-thiazol-2-yl]-2-[4-oxidanylidene-3-(2-phenylethyl)pteridin-2-yl]sulfanyl-ethanamide | 著者 | Lo, W.T, Roske, Y, Daumke, O, Haucke, V. | 登録日 | 2022-03-15 | 公開日 | 2022-08-31 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Development of selective inhibitors of phosphatidylinositol 3-kinase C2 alpha. Nat.Chem.Biol., 19, 2023
|
|
9C0Y
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 9c0y by Molmil](/molmil-images/mine/9c0y) | Clathrin terminal domain complexed with Pitstop 2c | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, Clathrin heavy chain 1, ... | 著者 | Bulut, H, Horatscheck, A, Krauss, M, Santos, K.F, McCluskey, A, Wahl, C.W, Nazare, M, Haucke, V. | 登録日 | 2024-05-28 | 公開日 | 2024-06-26 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Acute inhibition of clathrin-mediated endocytosis by next-generation small molecule inhibitors of clathrin function To Be Published
|
|
8A9I
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8a9i by Molmil](/molmil-images/mine/8a9i) | PI3KC2a core in complex with PITCOIN1 | 分子名称: | 1,2-ETHANEDIOL, 2-[4-oxidanylidene-3-(2-phenylethyl)pteridin-2-yl]sulfanyl-~{N}-(1,3-thiazol-2-yl)ethanamide, Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha, ... | 著者 | Lo, W.T, Roske, Y, Daumke, O, Haucke, V. | 登録日 | 2022-06-28 | 公開日 | 2022-08-31 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.87 Å) | 主引用文献 | Development of selective inhibitors of phosphatidylinositol 3-kinase C2 alpha. Nat.Chem.Biol., 19, 2023
|
|
2PR9
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2pr9 by Molmil](/molmil-images/mine/2pr9) | Mu2 adaptin subunit (AP50) of AP2 adaptor (second domain), complexed with GABAA receptor-gamma2 subunit-derived internalization peptide DEEYGYECL | 分子名称: | AP-2 complex subunit mu-1, GABA(A) receptor subunit gamma-2 peptide | 著者 | Vahedi-Faridi, A, Haucke, V, Kittler, J.T, Kukhtina, V, Moss, S.J, Saenger, W, Chen, G.-J, Tretter, V, Smith, K, Yan, Z, McAinsh, K, Arancibia-Carcamo, L. | 登録日 | 2007-05-04 | 公開日 | 2008-03-18 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.51 Å) | 主引用文献 | Regulation of synaptic inhibition by phospho-dependent binding of the AP2 complex to a YECL motif in the GABAA receptor gamma2 subunit. Proc.Natl.Acad.Sci.Usa, 105, 2008
|
|
9C0Z
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 9c0z by Molmil](/molmil-images/mine/9c0z) | Clathrin terminal domain complexed with pitstop 2d | 分子名称: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ACETATE ION, ... | 著者 | Bulut, H, Horatscheck, A, Krauss, M, Santos, K.F, McCluskey, A, Wahl, C.W, Nazare, M, Haucke, V. | 登録日 | 2024-05-28 | 公開日 | 2024-06-26 | 実験手法 | X-RAY DIFFRACTION (1.51 Å) | 主引用文献 | Acute inhibition of clathrin-mediated endocytosis by next-generation small molecule inhibitors of clathrin function To Be Published
|
|
2XZG
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2xzg by Molmil](/molmil-images/mine/2xzg) | Clathrin Terminal Domain Complexed with Pitstop 1 | 分子名称: | 2-(4-AMINOBENZYL)-1,3-DIOXO-2,3-DIHYDRO-1H-BENZO[DE]ISOQUINOLINE-5-SULFONATE, ACETATE ION, CLATHRIN HEAVY CHAIN 1, ... | 著者 | Bulut, H, Von Kleist, L, Saenger, W, Haucke, V. | 登録日 | 2010-11-25 | 公開日 | 2011-08-17 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Role of the Clathrin Terminal Domain in Regulating Coated Pit Dynamics Revealed by Small Molecule Inhibition. Cell(Cambridge,Mass.), 146, 2011
|
|
2JXC
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2jxc by Molmil](/molmil-images/mine/2jxc) | Structure of the EPS15-EH2 Stonin2 Complex | 分子名称: | CALCIUM ION, Epidermal growth factor receptor substrate 15, Stonin-2 | 著者 | Rumpf, J, Simon, B, Jung, N, Maritzen, T, Haucke, V, Sattler, M, Groemping, Y. | 登録日 | 2007-11-12 | 公開日 | 2008-01-08 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Structure of the Eps15-stonin2 complex provides a molecular explanation for EH-domain ligand specificity. Embo J., 27, 2008
|
|
4G55
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4g55 by Molmil](/molmil-images/mine/4g55) | Clathrin terminal domain complexed with pitstop 2 | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, Clathrin heavy chain 1, ... | 著者 | Bulut, H, Von Kleist, L, Saenger, W, Haucke, V. | 登録日 | 2012-07-17 | 公開日 | 2012-08-01 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.69 Å) | 主引用文献 | Role of the clathrin terminal domain in regulating coated pit dynamics revealed by small molecule inhibition. Cell(Cambridge,Mass.), 146, 2011
|
|
6E4L
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6e4l by Molmil](/molmil-images/mine/6e4l) | The structure of the N-terminal domain of human clathrin heavy chain 1 (nTD) in complex with ES9 | 分子名称: | 1,2-ETHANEDIOL, 5-bromo-N-(4-nitrophenyl)thiophene-2-sulfonamide, ACETATE ION, ... | 著者 | Dejonghe, W, Sharma, I, Denoo, B, Munck, S.D, Bulut, H, Mylle, E, Vasileva, M, Lu, Q, Savatin, D.V, Mishev, K, Nerinckx, W, Staes, A, Drozdzecki, A, Audenaert, D, Madder, A, Friml, J, Damme, D.V, Gevaert, K, Haucke, V, Savvides, S, Winne, J, Russinova, E. | 登録日 | 2018-07-17 | 公開日 | 2019-04-24 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Disruption of endocytosis through chemical inhibition of clathrin heavy chain function. Nat.Chem.Biol., 15, 2019
|
|
5A3F
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5a3f by Molmil](/molmil-images/mine/5a3f) | Crystal structure of the dynamin tetramer | 分子名称: | DYNAMIN 3 | 著者 | Reubold, T.F, Faelber, K, Plattner, N, Posor, Y, Branz, K, Curth, U, Schlegel, J, Anand, R, Manstein, D.J, Noe, F, Haucke, V, Daumke, O, Eschenburg, S. | 登録日 | 2015-05-29 | 公開日 | 2015-08-26 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (3.7 Å) | 主引用文献 | Crystal Structure of the Dynamin Tetramer Nature, 525, 2015
|
|
2X3W
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2x3w by Molmil](/molmil-images/mine/2x3w) | |
2X3V
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2x3v by Molmil](/molmil-images/mine/2x3v) | Structure of The F-BAR Domain of Mouse Syndapin I | 分子名称: | PROTEIN KINASE C AND CASEIN KINASE SUBSTRATE IN NEURONS PROTEIN 1 | 著者 | Ma, Q, Rao, Y, Vahedi-Faridi, A, Saenger, W, Haucke, V. | 登録日 | 2010-01-27 | 公開日 | 2010-04-07 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Molecular Basis for SH3 Domain Regulation of F-Bar-Mediated Membrane Deformation. Proc.Natl.Acad.Sci.USA, 107, 2010
|
|
2X3X
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2x3x by Molmil](/molmil-images/mine/2x3x) | structure of mouse syndapin I (crystal form 1) | 分子名称: | PROTEIN KINASE C AND CASEIN KINASE SUBSTRATE IN NEURONS PROTEIN 1 | 著者 | Ma, Q, Rao, Y, Vahedi-Faridi, A, Saenger, W, Haucke, V. | 登録日 | 2010-01-28 | 公開日 | 2010-04-07 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (3.35 Å) | 主引用文献 | Molecular Basis for SH3 Domain Regulation of F-Bar-Mediated Membrane Deformation. Proc.Natl.Acad.Sci.USA, 107, 2010
|
|
7BI9
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7bi9 by Molmil](/molmil-images/mine/7bi9) | PI3KC2a core in complex with PIK90 | 分子名称: | 1,2-ETHANEDIOL, N-(2,3-DIHYDRO-7,8-DIMETHOXYIMIDAZO[1,2-C] QUINAZOLIN-5-YL)NICOTINAMIDE, Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha,Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha | 著者 | Lo, W.T, Roske, Y, Daumke, O, Haucke, V. | 登録日 | 2021-01-12 | 公開日 | 2022-03-09 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Structural basis of phosphatidylinositol 3-kinase C2 alpha function. Nat.Struct.Mol.Biol., 29, 2022
|
|
7BI6
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7bi6 by Molmil](/molmil-images/mine/7bi6) | PI3KC2a core in complex with ATP | 分子名称: | 1,2-ETHANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Lo, W.T, Roske, Y, Daumke, O, Haucke, V. | 登録日 | 2021-01-12 | 公開日 | 2022-03-09 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Structural basis of phosphatidylinositol 3-kinase C2 alpha function. Nat.Struct.Mol.Biol., 29, 2022
|
|
7BI4
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7bi4 by Molmil](/molmil-images/mine/7bi4) | PI3KC2a core apo | 分子名称: | 1,2-ETHANEDIOL, Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha,Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha, SULFATE ION | 著者 | Lo, W.T, Roske, Y, Daumke, O, Haucke, V. | 登録日 | 2021-01-12 | 公開日 | 2022-03-09 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.42 Å) | 主引用文献 | Structural basis of phosphatidylinositol 3-kinase C2 alpha function. Nat.Struct.Mol.Biol., 29, 2022
|
|
7BI2
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7bi2 by Molmil](/molmil-images/mine/7bi2) | PI3KC2aDeltaN and DeltaC-C2 | 分子名称: | 1,2-ETHANEDIOL, 9-(6-aminopyridin-3-yl)-1-[3-(trifluoromethyl)phenyl]benzo[h][1,6]naphthyridin-2(1H)-one, IODIDE ION, ... | 著者 | Lo, W.T, Roske, Y, Daumke, O, Haucke, V. | 登録日 | 2021-01-12 | 公開日 | 2022-03-09 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (3.25 Å) | 主引用文献 | Structural basis of phosphatidylinositol 3-kinase C2 alpha function. Nat.Struct.Mol.Biol., 29, 2022
|
|
3H1Z
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3h1z by Molmil](/molmil-images/mine/3h1z) | Molecular basis for the association of PIPKIgamma -p90 with the clathrin adaptor AP-2 | 分子名称: | AP-2 complex subunit beta-1, Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma | 著者 | Vahedi-Faridi, A, Kahlfeldt, N, Schaefer, J.G, Krainer, G, Keller, S, Saenger, W, Krauss, M, Haucke, V. | 登録日 | 2009-04-14 | 公開日 | 2009-11-24 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | 主引用文献 | Molecular basis for association of PIPKI gamma-p90 with clathrin adaptor AP-2. J.Biol.Chem., 285, 2010
|
|
3HS8
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3hs8 by Molmil](/molmil-images/mine/3hs8) | Intersectin 1-peptide-AP2 alpha ear complex | 分子名称: | Adaptor protein complex AP-2, alpha 2 subunit, peptide from Intersectin-1, ... | 著者 | Vahedi-Faridi, A, Pechstein, A, Schaefer, J.G, Saenger, W, Haucke, V. | 登録日 | 2009-06-10 | 公開日 | 2010-02-23 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Regulation of synaptic vesicle recycling by complex formation between intersectin 1 and the clathrin adaptor complex AP2. Proc.Natl.Acad.Sci.USA, 107, 2010
|
|
3HS9
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3hs9 by Molmil](/molmil-images/mine/3hs9) | Intersectin 1-peptide-AP2 beta ear complex | 分子名称: | AP-2 complex subunit beta-1, peptide from Intersectin-1, residues 841-851 | 著者 | Vahedi-Faridi, A, Pechstein, A, Schaefer, J.G, Saenger, W, Haucke, V. | 登録日 | 2009-06-10 | 公開日 | 2010-02-23 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Regulation of synaptic vesicle recycling by complex formation between intersectin 1 and the clathrin adaptor complex AP2. Proc.Natl.Acad.Sci.USA, 107, 2010
|
|
3H85
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3h85 by Molmil](/molmil-images/mine/3h85) | Molecular basis for the association of PIPKI gamma-p90 with the clathrin adaptor AP-2 | 分子名称: | AP-2 complex subunit mu-1, NICKEL (II) ION, Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma | 著者 | Vahedi-Faridi, A, Kahlfeldt, N, Schaefer, J.G, Haucke, V. | 登録日 | 2009-04-28 | 公開日 | 2009-11-24 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Molecular basis for association of PIPKI gamma-p90 with clathrin adaptor AP-2. J.Biol.Chem., 285, 2010
|
|