Loading
PDBj
English日本語简体中文繁體中文한국어
✖
ﾒﾆｭｰPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
PDB: 22 件
7Z75
DownloadVisualize
BU of 7z75 by Molmil
PI3KC2a core in complex with PITCOIN3
分子名称: 1,2-ETHANEDIOL, Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha, SULFATE ION, ...
著者Lo, W.T, Roske, Y, Daumke, O, Haucke, V.
登録日2022-03-15
公開日2022-08-31
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.59 Å)
主引用文献Development of selective inhibitors of phosphatidylinositol 3-kinase C2 alpha.
Nat.Chem.Biol., 19, 2023
7Z74
DownloadVisualize
BU of 7z74 by Molmil
PI3KC2a core in complex with PITCOIN2
分子名称: 1,2-ETHANEDIOL, Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha, ~{N}-[4-(3-hydroxyphenyl)-1,3-thiazol-2-yl]-2-[4-oxidanylidene-3-(2-phenylethyl)pteridin-2-yl]sulfanyl-ethanamide
著者Lo, W.T, Roske, Y, Daumke, O, Haucke, V.
登録日2022-03-15
公開日2022-08-31
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Development of selective inhibitors of phosphatidylinositol 3-kinase C2 alpha.
Nat.Chem.Biol., 19, 2023
9C0Y
DownloadVisualize
BU of 9c0y by Molmil
Clathrin terminal domain complexed with Pitstop 2c
分子名称: 1,2-ETHANEDIOL, ACETATE ION, Clathrin heavy chain 1, ...
著者Bulut, H, Horatscheck, A, Krauss, M, Santos, K.F, McCluskey, A, Wahl, C.W, Nazare, M, Haucke, V.
登録日2024-05-28
公開日2024-06-26
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Acute inhibition of clathrin-mediated endocytosis by next-generation small molecule inhibitors of clathrin function
To Be Published
8A9I
DownloadVisualize
BU of 8a9i by Molmil
PI3KC2a core in complex with PITCOIN1
分子名称: 1,2-ETHANEDIOL, 2-[4-oxidanylidene-3-(2-phenylethyl)pteridin-2-yl]sulfanyl-~{N}-(1,3-thiazol-2-yl)ethanamide, Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha, ...
著者Lo, W.T, Roske, Y, Daumke, O, Haucke, V.
登録日2022-06-28
公開日2022-08-31
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.87 Å)
主引用文献Development of selective inhibitors of phosphatidylinositol 3-kinase C2 alpha.
Nat.Chem.Biol., 19, 2023
2PR9
DownloadVisualize
BU of 2pr9 by Molmil
Mu2 adaptin subunit (AP50) of AP2 adaptor (second domain), complexed with GABAA receptor-gamma2 subunit-derived internalization peptide DEEYGYECL
分子名称: AP-2 complex subunit mu-1, GABA(A) receptor subunit gamma-2 peptide
著者Vahedi-Faridi, A, Haucke, V, Kittler, J.T, Kukhtina, V, Moss, S.J, Saenger, W, Chen, G.-J, Tretter, V, Smith, K, Yan, Z, McAinsh, K, Arancibia-Carcamo, L.
登録日2007-05-04
公開日2008-03-18
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.51 Å)
主引用文献Regulation of synaptic inhibition by phospho-dependent binding of the AP2 complex to a YECL motif in the GABAA receptor gamma2 subunit.
Proc.Natl.Acad.Sci.Usa, 105, 2008
9C0Z
DownloadVisualize
BU of 9c0z by Molmil
Clathrin terminal domain complexed with pitstop 2d
分子名称: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ACETATE ION, ...
著者Bulut, H, Horatscheck, A, Krauss, M, Santos, K.F, McCluskey, A, Wahl, C.W, Nazare, M, Haucke, V.
登録日2024-05-28
公開日2024-06-26
実験手法X-RAY DIFFRACTION (1.51 Å)
主引用文献Acute inhibition of clathrin-mediated endocytosis by next-generation small molecule inhibitors of clathrin function
To Be Published
2XZG
DownloadVisualize
BU of 2xzg by Molmil
Clathrin Terminal Domain Complexed with Pitstop 1
分子名称: 2-(4-AMINOBENZYL)-1,3-DIOXO-2,3-DIHYDRO-1H-BENZO[DE]ISOQUINOLINE-5-SULFONATE, ACETATE ION, CLATHRIN HEAVY CHAIN 1, ...
著者Bulut, H, Von Kleist, L, Saenger, W, Haucke, V.
登録日2010-11-25
公開日2011-08-17
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Role of the Clathrin Terminal Domain in Regulating Coated Pit Dynamics Revealed by Small Molecule Inhibition.
Cell(Cambridge,Mass.), 146, 2011
2JXC
DownloadVisualize
BU of 2jxc by Molmil
Structure of the EPS15-EH2 Stonin2 Complex
分子名称: CALCIUM ION, Epidermal growth factor receptor substrate 15, Stonin-2
著者Rumpf, J, Simon, B, Jung, N, Maritzen, T, Haucke, V, Sattler, M, Groemping, Y.
登録日2007-11-12
公開日2008-01-08
最終更新日2024-05-01
実験手法SOLUTION NMR
主引用文献Structure of the Eps15-stonin2 complex provides a molecular explanation for EH-domain ligand specificity.
Embo J., 27, 2008
4G55
DownloadVisualize
BU of 4g55 by Molmil
Clathrin terminal domain complexed with pitstop 2
分子名称: 1,2-ETHANEDIOL, ACETATE ION, Clathrin heavy chain 1, ...
著者Bulut, H, Von Kleist, L, Saenger, W, Haucke, V.
登録日2012-07-17
公開日2012-08-01
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.69 Å)
主引用文献Role of the clathrin terminal domain in regulating coated pit dynamics revealed by small molecule inhibition.
Cell(Cambridge,Mass.), 146, 2011
6E4L
DownloadVisualize
BU of 6e4l by Molmil
The structure of the N-terminal domain of human clathrin heavy chain 1 (nTD) in complex with ES9
分子名称: 1,2-ETHANEDIOL, 5-bromo-N-(4-nitrophenyl)thiophene-2-sulfonamide, ACETATE ION, ...
著者Dejonghe, W, Sharma, I, Denoo, B, Munck, S.D, Bulut, H, Mylle, E, Vasileva, M, Lu, Q, Savatin, D.V, Mishev, K, Nerinckx, W, Staes, A, Drozdzecki, A, Audenaert, D, Madder, A, Friml, J, Damme, D.V, Gevaert, K, Haucke, V, Savvides, S, Winne, J, Russinova, E.
登録日2018-07-17
公開日2019-04-24
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Disruption of endocytosis through chemical inhibition of clathrin heavy chain function.
Nat.Chem.Biol., 15, 2019
5A3F
DownloadVisualize
BU of 5a3f by Molmil
Crystal structure of the dynamin tetramer
分子名称: DYNAMIN 3
著者Reubold, T.F, Faelber, K, Plattner, N, Posor, Y, Branz, K, Curth, U, Schlegel, J, Anand, R, Manstein, D.J, Noe, F, Haucke, V, Daumke, O, Eschenburg, S.
登録日2015-05-29
公開日2015-08-26
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (3.7 Å)
主引用文献Crystal Structure of the Dynamin Tetramer
Nature, 525, 2015
2X3W
DownloadVisualize
BU of 2x3w by Molmil
structure of mouse syndapin I (crystal form 2)
分子名称: PROTEIN KINASE C AND CASEIN KINASE SUBSTRATE IN NEURONS PROTEIN 1
著者Ma, Q, Rao, Y, Saenger, W, Haucke, V.
登録日2010-01-28
公開日2010-04-07
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.64 Å)
主引用文献Molecular Basis for SH3 Domain Regulation of F-Bar-Mediated Membrane Deformation.
Proc.Natl.Acad.Sci.USA, 107, 2010
2X3V
DownloadVisualize
BU of 2x3v by Molmil
Structure of The F-BAR Domain of Mouse Syndapin I
分子名称: PROTEIN KINASE C AND CASEIN KINASE SUBSTRATE IN NEURONS PROTEIN 1
著者Ma, Q, Rao, Y, Vahedi-Faridi, A, Saenger, W, Haucke, V.
登録日2010-01-27
公開日2010-04-07
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Molecular Basis for SH3 Domain Regulation of F-Bar-Mediated Membrane Deformation.
Proc.Natl.Acad.Sci.USA, 107, 2010
2X3X
DownloadVisualize
BU of 2x3x by Molmil
structure of mouse syndapin I (crystal form 1)
分子名称: PROTEIN KINASE C AND CASEIN KINASE SUBSTRATE IN NEURONS PROTEIN 1
著者Ma, Q, Rao, Y, Vahedi-Faridi, A, Saenger, W, Haucke, V.
登録日2010-01-28
公開日2010-04-07
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (3.35 Å)
主引用文献Molecular Basis for SH3 Domain Regulation of F-Bar-Mediated Membrane Deformation.
Proc.Natl.Acad.Sci.USA, 107, 2010
7BI9
DownloadVisualize
BU of 7bi9 by Molmil
PI3KC2a core in complex with PIK90
分子名称: 1,2-ETHANEDIOL, N-(2,3-DIHYDRO-7,8-DIMETHOXYIMIDAZO[1,2-C] QUINAZOLIN-5-YL)NICOTINAMIDE, Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha,Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
著者Lo, W.T, Roske, Y, Daumke, O, Haucke, V.
登録日2021-01-12
公開日2022-03-09
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Structural basis of phosphatidylinositol 3-kinase C2 alpha function.
Nat.Struct.Mol.Biol., 29, 2022
7BI6
DownloadVisualize
BU of 7bi6 by Molmil
PI3KC2a core in complex with ATP
分子名称: 1,2-ETHANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
著者Lo, W.T, Roske, Y, Daumke, O, Haucke, V.
登録日2021-01-12
公開日2022-03-09
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Structural basis of phosphatidylinositol 3-kinase C2 alpha function.
Nat.Struct.Mol.Biol., 29, 2022
7BI4
DownloadVisualize
BU of 7bi4 by Molmil
PI3KC2a core apo
分子名称: 1,2-ETHANEDIOL, Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha,Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha, SULFATE ION
著者Lo, W.T, Roske, Y, Daumke, O, Haucke, V.
登録日2021-01-12
公開日2022-03-09
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.42 Å)
主引用文献Structural basis of phosphatidylinositol 3-kinase C2 alpha function.
Nat.Struct.Mol.Biol., 29, 2022
7BI2
DownloadVisualize
BU of 7bi2 by Molmil
PI3KC2aDeltaN and DeltaC-C2
分子名称: 1,2-ETHANEDIOL, 9-(6-aminopyridin-3-yl)-1-[3-(trifluoromethyl)phenyl]benzo[h][1,6]naphthyridin-2(1H)-one, IODIDE ION, ...
著者Lo, W.T, Roske, Y, Daumke, O, Haucke, V.
登録日2021-01-12
公開日2022-03-09
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (3.25 Å)
主引用文献Structural basis of phosphatidylinositol 3-kinase C2 alpha function.
Nat.Struct.Mol.Biol., 29, 2022
3H1Z
DownloadVisualize
BU of 3h1z by Molmil
Molecular basis for the association of PIPKIgamma -p90 with the clathrin adaptor AP-2
分子名称: AP-2 complex subunit beta-1, Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma
著者Vahedi-Faridi, A, Kahlfeldt, N, Schaefer, J.G, Krainer, G, Keller, S, Saenger, W, Krauss, M, Haucke, V.
登録日2009-04-14
公開日2009-11-24
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.83 Å)
主引用文献Molecular basis for association of PIPKI gamma-p90 with clathrin adaptor AP-2.
J.Biol.Chem., 285, 2010
3HS8
DownloadVisualize
BU of 3hs8 by Molmil
Intersectin 1-peptide-AP2 alpha ear complex
分子名称: Adaptor protein complex AP-2, alpha 2 subunit, peptide from Intersectin-1, ...
著者Vahedi-Faridi, A, Pechstein, A, Schaefer, J.G, Saenger, W, Haucke, V.
登録日2009-06-10
公開日2010-02-23
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Regulation of synaptic vesicle recycling by complex formation between intersectin 1 and the clathrin adaptor complex AP2.
Proc.Natl.Acad.Sci.USA, 107, 2010
3HS9
DownloadVisualize
BU of 3hs9 by Molmil
Intersectin 1-peptide-AP2 beta ear complex
分子名称: AP-2 complex subunit beta-1, peptide from Intersectin-1, residues 841-851
著者Vahedi-Faridi, A, Pechstein, A, Schaefer, J.G, Saenger, W, Haucke, V.
登録日2009-06-10
公開日2010-02-23
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Regulation of synaptic vesicle recycling by complex formation between intersectin 1 and the clathrin adaptor complex AP2.
Proc.Natl.Acad.Sci.USA, 107, 2010
3H85
DownloadVisualize
BU of 3h85 by Molmil
Molecular basis for the association of PIPKI gamma-p90 with the clathrin adaptor AP-2
分子名称: AP-2 complex subunit mu-1, NICKEL (II) ION, Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma
著者Vahedi-Faridi, A, Kahlfeldt, N, Schaefer, J.G, Haucke, V.
登録日2009-04-28
公開日2009-11-24
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Molecular basis for association of PIPKI gamma-p90 with clathrin adaptor AP-2.
J.Biol.Chem., 285, 2010

224004

件を2024-08-21に公開中

PDB statisticsPDBj update infoContact PDBjnumon