7BI6

PI3KC2a core in complex with ATP

Summary for 7BI6

• Entry DOI: 10.2210/pdb7bi6/pdb
• Descriptor: Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha,Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha, ADENOSINE-5'-TRIPHOSPHATE, SULFATE ION, ... (6 entities in total)
• Functional Keywords: pi3kc2 alpha, kinase, transferase
• Biological source: Mus musculus (House Mouse); More
• Total number of polymer chains: 1
• Total formula weight: 103333.77

Authors

Lo, W.T.,Roske, Y.,Daumke, O.,Haucke, V. (deposition date: 2021-01-12, release date: 2022-03-09, Last modification date: 2024-01-31)

• Primary citation: Lo, W.T.,Zhang, Y.,Vadas, O.,Roske, Y.,Gulluni, F.,De Santis, M.C.,Zagar, A.V.,Stephanowitz, H.,Hirsch, E.,Liu, F.,Daumke, O.,Kudryashev, M.,Haucke, V.; Structural basis of phosphatidylinositol 3-kinase C2 alpha function.; Nat.Struct.Mol.Biol., 29:218-228, 2022; PubMed: 35256802; DOI: 10.1038/s41594-022-00730-w

Experimental method

X-RAY DIFFRACTION (2.75 Å)