7BI6

PI3KC2a core in complex with ATP

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha,Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha	polymer	910	102486.0	1	UniProt (Q61194) Pfam (PF00794) Pfam (PF00792) Pfam (PF00613) Pfam (PF00454)	Mus musculus (House Mouse)	PtdIns-3-kinase C2 subunit alpha,Cpk-m,Phosphoinositide 3-kinase-C2-alpha,p170,PtdIns-3-kinase C2 subunit alpha,Cpk-m,Phosphoinositide 3-kinase-C2-alpha,p170
2	B (A)	ADENOSINE-5'-TRIPHOSPHATE	non-polymer		507.2	1	Chemie (ATP)
3	C, D (A)	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
4	E, F (A)	1,2-ETHANEDIOL	non-polymer		62.1	2	Chemie (EDO)
5	G (A)	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)
6	H (A)	water	water		18.0	86	Chemie (HOH)

Sequence modifications

A: 3 - 158 (UniProt: Q61194)

PDB	External Database	Details
Gly 1	-	expression tag
Ala 2	-	expression tag

A: 284 - 1018 (UniProt: Q61194)

PDB	External Database	Details
Gly 159	-	linker
Ser 268	-	linker
Gly 269	-	linker
Ser 270	-	linker
Val 271	-	linker
Met 272	-	linker
Thr 273	-	linker
Arg 274	-	linker
His 275	-	linker
Ser 276	-	linker
Ala 277	-	linker
Gly 278	-	linker
Ala 279	-	linker
Gly 280	-	linker
Ser 281	-	linker
Gly 282	-	linker
Ala 283	-	linker
Gly 286	Ala 668	conflict
Ala 353	Phe 735	engineered mutation
Ala 354	Phe 736	engineered mutation
Ala 427	Leu 809	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	102486.0
Non-Polymers*	Number of molecules	6
	Total formula weight	847.7
All*	Total formula weight	103333.8

*Water molecules are not included.