6E4L
The structure of the N-terminal domain of human clathrin heavy chain 1 (nTD) in complex with ES9
Summary for 6E4L
Entry DOI | 10.2210/pdb6e4l/pdb |
Descriptor | Clathrin heavy chain 1, DIMETHYL SULFOXIDE, GLYCEROL, ... (7 entities in total) |
Functional Keywords | clathrin-mediated endocytosis (cme), clathrin n-terminal domain (ntd), chemical inhibition, endocytosis |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 41973.87 |
Authors | Dejonghe, W.,Sharma, I.,Denoo, B.,Munck, S.D.,Bulut, H.,Mylle, E.,Vasileva, M.,Lu, Q.,Savatin, D.V.,Mishev, K.,Nerinckx, W.,Staes, A.,Drozdzecki, A.,Audenaert, D.,Madder, A.,Friml, J.,Damme, D.V.,Gevaert, K.,Haucke, V.,Savvides, S.,Winne, J.,Russinova, E. (deposition date: 2018-07-17, release date: 2019-04-24, Last modification date: 2023-10-11) |
Primary citation | Dejonghe, W.,Sharma, I.,Denoo, B.,De Munck, S.,Lu, Q.,Mishev, K.,Bulut, H.,Mylle, E.,De Rycke, R.,Vasileva, M.,Savatin, D.V.,Nerinckx, W.,Staes, A.,Drozdzecki, A.,Audenaert, D.,Yperman, K.,Madder, A.,Friml, J.,Van Damme, D.,Gevaert, K.,Haucke, V.,Savvides, S.N.,Winne, J.,Russinova, E. Disruption of endocytosis through chemical inhibition of clathrin heavy chain function. Nat.Chem.Biol., 15:641-649, 2019 Cited by PubMed: 31011214DOI: 10.1038/s41589-019-0262-1 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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