6E4L
The structure of the N-terminal domain of human clathrin heavy chain 1 (nTD) in complex with ES9
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005198 | molecular_function | structural molecule activity |
| A | 0006886 | biological_process | intracellular protein transport |
| A | 0016192 | biological_process | vesicle-mediated transport |
| A | 0030130 | cellular_component | clathrin coat of trans-Golgi network vesicle |
| A | 0030132 | cellular_component | clathrin coat of coated pit |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue DMS A 401 |
| Chain | Residue |
| A | PHE27 |
| A | THR31 |
| A | ILE72 |
| A | PHE110 |
| A | TRP111 |
| A | HOH529 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue DMS A 402 |
| Chain | Residue |
| A | HOH521 |
| A | ARG176 |
| A | VAL177 |
| A | GLN257 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 403 |
| Chain | Residue |
| A | ARG157 |
| A | ALA263 |
| A | MET264 |
| A | VAL305 |
| A | THR306 |
| A | HOH554 |
| A | HOH586 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 404 |
| Chain | Residue |
| A | GLU301 |
| A | GLN343 |
| A | ASN344 |
| A | HOH509 |
| A | HOH536 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 405 |
| Chain | Residue |
| A | LYS140 |
| A | MET141 |
| A | TYR184 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | binding site for residue ACT A 406 |
| Chain | Residue |
| A | ARG64 |
| A | ILE93 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue ACT A 407 |
| Chain | Residue |
| A | GLN203 |
| A | LYS205 |
| A | GLU268 |
| A | ASP271 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | binding site for residue ACT A 408 |
| Chain | Residue |
| A | ARG297 |
| A | GLY300 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | binding site for residue HRS A 409 |
| Chain | Residue |
| A | ARG64 |
| A | ILE66 |
| A | SER67 |
| A | ILE80 |
| A | LEU82 |
| A | PHE91 |
| A | GLN174 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 43 |
| Details | Region: {"description":"WD40-like repeat 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 39 |
| Details | Region: {"description":"WD40-like repeat 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 41 |
| Details | Region: {"description":"WD40-like repeat 3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 45 |
| Details | Region: {"description":"WD40-like repeat 4"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 61 |
| Details | Region: {"description":"WD40-like repeat 5"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 43 |
| Details | Region: {"description":"WD40-like repeat 6"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 28 |
| Details | Region: {"description":"WD40-like repeat 7"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Calvo F.","Matallanas D.","Cooper W.N.","Boldt K.","von Kriegsheim A.F.","Kolch W."]}},{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"25944712","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q68FD5","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q68FD5","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
